Search results for: 'Peptide'

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Cat.No. 产品名称 Information
GA20534 Acetyl-Amyloid β-Protein (15-20) amide Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.
GA20502 Ac-D-Ala-D-lactic acid Bacterial cell-wall peptide analog. In glycopeptide antibiotic-resistant enterococci (VanA and VanB types) the terminal sequence D-Ala-D-Ala is substituted by D-Ala-D-Lac leading to a 1000-fold decrease in affinity of a glycopeptide antibiotic to its target.
GA20493 Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid)
半胱胺酸蛋白酶-10(抗体)
Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM).
GA20487 Ac-Arg-Ser-Leu-Lys-AMC Ac-RSLK-AMC, a fluorogenic substrate for Site-1 protease (S1P), a mammalian subtilisin-related serine protease that cleaves sterol regulatory element-binding proteins (SREBPs). The peptide sequence RSLK corresponds to the internal propeptide cleavage site that generates active S1P.
GA20477 Ac-Ala-pNA
N-乙酰基-L-丙氨酸对硝基苯酰
AANA, substrate for acylaminoacyl peptidases (APH, acyl peptide hydrolase), an enzyme able to degrade monomeric and oligomeric amyloid peptides
GA20471 Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde Acetyl-AAVALLPAVLLALLAP-IETD-CHO, the potent reversible caspase-8 inhibitor IETD-CHO (N-1620) is rendered cell-permeable by attaching a non-polar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signal peptide sequence.
GA20466 Ac-Ala-Ala-Ala-OH
N-乙酰基-L-丙氨酰-L-丙氨酰-L-丙氨酸
Ac-AAA, suitable substrate for acylaminoacyl peptidase (N-acyl-peptide hydrolase). This enzyme releases acylamino acids from N-acylated peptides and may therefore play a role in protein degradation.
GA20454 Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH
Internally quenched fluorogenic peptide substrate containing anthranilic acid as fluorescent donor and m-nitro-tyrosine as acceptor (quencher).
GA20439 5-FAM-Woodtide FAM-labeled Forkhead derived peptide woodtide (ab/em = 494/521 nm) is used as a substrate for the DYRK family of kinases in in-vitro analysis. Woodtide corresponds to residues 324-334 of transcription factor FKHR with two lysine residues added at the N-terminus to facilitate binding to phosphocellulose paper.
GA20416 4-Formyl-3-methoxy-phenyloxymethyl polystyrene resin (200-400 mesh) For Fmoc solid phase synthesis of N-alkyl peptide amides by reductive amination.
GA20406 4-(Fmoc-hydrazino)-benzoic acid
4-(2-氨基保护羧基)苯甲酸
This linker which is stable to acid and bases is cleaved with high specificity under mild oxidative conditions in the presence of base and a nucleophile, yielding a range of C-terminal functionalities. The linker may be used to synthesize fully or partially protected peptides for fragment coupling. See also D-2560.
GA20402 4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g) Resin for the Fmoc-SPPS of peptide amides. Cleavage was achieved with 50 % TFA in CH?Cl?. or 95% TFA Scavengers may be required. (EP 0 285 562 B1 licensed to glpbio)
GA20392 3-(4-Methoxy-benzylsulfanyl)-3-methyl-butyric acid S-protected derivative for the introduction of a deamino-penicillamine residue. Building block for the preparation of oxytocin and vasopressin antagonists. Peptide thioesters for chemical ligation may be obtained by Fmoc-SPPS using a deaminopenicillamine-derived linker, as premature cleavage during Fmoc removal is inhibited by steric hindrance. Tegge et al. developed a deaminopenicillamine-based disulfide linker for the Fmoc-SPPS of cyclic Cys-containing peptides.
GA20336 (Tyr⁶⁹,Ala⁷¹·⁷²,Lys⁷⁴)-C3a (69-77) The peptide YAAALKLAR, which has been modeled after the C-terminus of the anaphylatoxin C3a, constitutes a potent inhibitor of C3a activity. The Lys?? residue contributes to the separation between deactivation and activation of the C3a receptor.
GA20327 (Tyr¹)-TRAP-7 The TRAP-7 analog YFLLRNP is an antagonist to α-thrombin and to the thrombin receptor agonist peptide SFLLRNP in human platelets. It might be a useful tool for the differentiation between several possible activation states of the human platelet thrombin receptor.
GA20317 (Trp⁶³,Trp⁶⁴)-C3a (63-77) (Trp?³,Trp??)-C3a (63-77), synthetic superagonist analog of complement 3a, exhibited the greatest biological potency of all peptides tested. The peptide was 12-15 times more active than natural C3a. Such an optimal potency was obtained by introducing a bulky hydrophobic group such as Trp-Trp which binds more strongly to the hydrophobic site on the receptor than does the corresponding site on the natural ligand.
GA20312 (Thr⁵⁰⁶)-α-1,3-Glucosyltransferase (500-520) mAlg8 peptide sequence from α-1,3-Glucosyltransferase (A506T mutation) containing the epitope ITYTWTRL which binds to murine MHC H-2Kb. ITYTWTRL is a tumor-specific mutant antigen in T3 MCA sarcomas.
GA20283 (Pyr³)-Amyloid β-Protein (3-40) The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
GA20282 (Pyr¹¹)-Amyloid β-Protein (11-40) pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
GA20273 (Phe⁴)-Dermorphin (1-4) amide TAPP, a relatively lipophilic peptide, shows high µ-receptor affinity, excellent µ-selectivity, and seems to be able to cross the blood-brain barrier.
GA20266 (N-Me-Tyr¹,N-Me-Arg⁷,D-Leu-NHEt⁸)-Dynorphin A (1-8) Highly stable dynorphin-like analgesic peptide.
GA20259 (Nle³⁵)-Amyloid β-Protein (1-40) The reactive thioether of Met³? is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
GA20226 (Ile⁷⁶)-TNF-α (70-80) (human) The peptide PSTHVLITHTI corresponds to residues 70-80 of human TNF-α substituted with Ile at position 76 and exhibits many of the biological activities found for TNF-α. (Ile??)-TNF-α (70-80) has been shown to enhance human polymorphonuclear-mediated killing of Plasmodium falciparum in vitro and to reduce Plasmodium chabaudi parasitemia in mice. However, in vivo toxicity studies showed that (Ile??)-TNF-α (70-80) does not possess the typical toxic effects of TNF.
GA20220 (H-Lys-Ile-Leu-Asn-Asp-Leu-Ser-Ser-Asp-Ala-Pro-Gly-Val-Pro-Arg)₈-MAP Multiple antigenic peptide (KILNDLSSDAPGVPR)?-MAP, the sequence corresponds to rat CREB (136-150).
GA20219 (His³²,Leu³⁴)-Neuropeptide Y (32-36) The inactive NPY carboxy-terminal pentapeptide (IC?? > 100 µM) was modified by replacing threonine with histidine and glutamine with leucine. The resulting peptide had a dramatically improved affinity (IC?? = 0.45 µM) for the rat brain receptor.
GA20214 (H-Cys-βNA)₂
L-胱氨酰二(2-萘胺)
Substrate for cystyl aminopeptidase (oxytocinase). Educt for the synthesis of peptides containing the Dmt (5,5-dimethyl-4-thiaproline) motif.
GA20202 (H-Asp-Glu-Val-Asp)₂-Rhodamine 110 (DEVD)?-R110, non-fluorescent peptidyl (DEVD)-Rhodamine 110-bisamide, is a highly sensitive, photostable fluorogenic substrate for the determination of caspase-3 activity. Characteristic for substrates based on Rhodamine 110 (R110) is that they contain two identical amino acids or peptides attached to a single fluorophor thereby suppressing its visible absorption and its fluorescence. Upon enzymatic cleavage, this substrate is converted first to the fluorescent monoamide and then to the even more fluorescent R110. The spectral properties of these hydrolysis products are similar to those of fluorescein, with peak excitation and emission wavelengths of 496 and 520 nm, respectively. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy. Useful for high throughput screening applications.
GA20200 (Gly²²)-Amyloid β-Protein (1-42) The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
GA20197 (Gly²¹)-Amyloid β-Protein (1-40) Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
GA20187 (Glu¹³·¹⁷·²⁰)-Osteocalcin (1-46) (mouse) Non-carboxylated osteocalcin was shown to be a bone-specific hormone involved in the regulation of glucose metabolism, for which the Gla peptide acts as precursor and transport form.
GA20184 (Gln²²,Asn²³)-Amyloid β-Protein (1-40) Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
GA20180 (Fmoc-Glu⁷⁰,Ala⁷¹·⁷²,Lys⁷⁴)-C3a (70-77) The peptide Fmoc-EAALKLAR, which has been modeled after the C-terminus of the anaphylatoxin C3a, is a potent inhibitor of C3a activity. It is preferred for testing C3a-desensitizing capacity in vivo.
GA20179 (Fmoc-Cys-OtBu)₂ Cystine precursor of Fmoc-Cys-OtBu which has been used in the synthesis of orthogonally protected lanthionines. Barany et al. employed Fmoc-Cys-OtBu in developing a side-chain anchoring strategy for the SPPS of peptide acids with C-terminal cysteine.
GA20171 (D-Trp⁷,Ala⁸,D-Phe¹⁰)-α-MSH (6-11) amide
生长激素释放肽-6
In search of competitive α-MSH antagonists, the hexapeptide GHRP-6 has been recognized as a selective inhibitor of α-MSH activity in the frog skin bioassay. It is identical in sequence with a growth hormone-releasing peptide analog, (His¹,Lys?)-GHRP, which selectively releases GH in vitro and in a wide variety of species in vivo. GHRP-6 also acts as a functional antagonist of somatostatin in the somatotrope cells.
GA20144 (D-Pen²,p-chloro-Phe⁴,D-Pen⁵)-Enkephalin The introduction of a chloro substituent in para-position of the Phe? aromatic ring of DPDPE led to a compound with 5 times higher δ-selectivity than the parent peptide due to a 5-fold increased δ-receptor affinity. For this reason, (Cpa?)-DPDPE may prove to be the ligand of choice for studying the properties of δ-opioid receptors.
GA20113 (Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHEt⁹)-LHRH
布舍瑞林
Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. CAS Number (buserelin acetate): 68630-75-1.
GA20076 (D-Arg²)-Kyotorphin D-Kyotorphin showed higher analgesic activity in rats than kyotorphin (G-2450), though the analgesic actions of these diastereomeric dipeptides probably resulted from different mechanisms. Contrary to G-2450, only minimal modulation of the Na?/Cl?dependant opioid peptide transporter was effected by this analog.
GA20051 (Cys¹⁸)-Atrial Natriuretic Factor (4-18) amide (mouse, rabbit, rat) C-ANF 4-23 binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. It competes effectively with biologically active atrial peptides for binding sites but is devoid of agonist or antagonist action on the generation of cGMP in vascular smooth muscle and endothelial cells in culture.
GA20050 (Cys⁰)-Amyloid β-Protein (1-40) Cys-Aβ1-40 can be easily and selectively modified, labeled, coupled to carriers e.g. by maleimide chemistry without affecting the sequences involved in fibril formation. The free mercapto moiety of the peptide adheres to gold surfaces.
GA20048 (Boc-Cys-OH)₂
N,N'-双(叔丁氧羰基)-L-胱氨酸
Tai et al. could obtain asymmetric cystine peptides from (Boc-Cys-OH)? by enzymatic catalysis with immobilized papain. Oxidation of Boc-cystine with hydrogen peroxide in the presence of Na wolframate yielded the sodium salt of Boc-cysteic acid. Boc cystine benzyl ester was used as educt for obtaining S-isoacyl dipeptide building blocks.
GA20042 (Asn⁷)-Amyloid β-Protein (1-40) The Tottori (D7N) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
GA20041 (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC?? = 30 nM.
GA20040 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)
Β-基质分泌酶Ⅱ
This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
GA20039 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675) SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
GA20029 (Arg¹³)-Amyloid β-Protein (1-40) H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
GA20006 ([¹³C₆;¹⁵N]Leu³·¹⁶·¹⁹·²⁰·³¹·³³)-Orexin A (human, mouse, rat) Stable isotope-labeled orexin A analog for use as internal standard in a sensitive quantitative mass spectrometry assay of the peptide hormone in cerebrospinal fluid.
GC45592 Urotensin I (white sucker) (trifluoroacetate salt) A peptide
GC45576 TFLLR-NH2 (trifluoroacetate salt) A peptide agonist of PAR1
GC45565 Semax
脑力肽
A synthetic peptide with neuroprotective, analgesic, and anxiolytic properties
GC45541 PAR3 (1-6) amide (human) (trifluoroacetate salt)
Proteinase-Activated Receptor 3, TFRGAP-NH2
A peptide agonist of PAR1 and PAR2

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