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Thrombin(凝血酶)

Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.

  1. Cat.No. 产品名称 Information
  2. GP26352 THBD Human THBD Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 500 amino acids (22-515a
  3. GC62439 Edoxaban impurity 6
  4. GC62298 Edoxaban impurity 4
  5. GC19766 Heparin sodium salt (MW 15kDa) 肝素钠盐(MW 15kDa)(Sodium heparin (MW 15kDa))是肝素的聚合物,分子量为15kDa。
  6. GC61787 Dabigatran D4 hydrochloride
  7. GC61495 Thrombin (MW 37kDa) 凝血酶 (MW 37kDa) 是一种 Na+- 激活的变构丝氨酸蛋白酶。凝血酶诱导 ERK1 和 ERK2 的激活
  8. GC60240 Melagatran
  9. GC39515 TP508 TFA
  10. GC38332 Ximelagatran A prodrug of melagatran, a thrombin inhibitor
  11. GC37785 Thrombin Inhibitor 2
  12. GC36792 Odiparcil
  13. GC35802 Dabigatran ethyl ester hydrochloride
  14. GC35528 Bivalirudin TFA A thrombin inhibitor
  15. GC35384 Argatroban monohydrate A thrombin inhibitor
  16. GP24824 Thrombin 人类凝血酶
  17. GC34373 Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride)
  18. GC34255 TP508
  19. GC34032 Napsagatran hydrate (Ro 46-6240 hydrate)
  20. GC32663 Desethyl KBT-3022
  21. GC32639 Thrombin inhibitor 1
  22. GC32619 OM-189
  23. GC32567 RWJ-445167 (3DP-10017)
  24. GC32554 Inogatran (H-314-27)
  25. GC18249 NQ301 A naphthoquinone with diverse biological activities
  26. GC17423 TS 155-2 An antihypertensive antibiotic
  27. GC17362 Metolazone A thiazide-like diuretic
  28. GC10140 Thrombin Receptor Agonist Peptide A peptide agonist of the α-thrombin receptor
  29. GC15180 BIBR-1048 A prodrug form of dabigatran
  30. GC11672 Argatroban A thrombin inhibitor
  31. GC10398 Heparin sodium 肝素钠(Heparin sodium)作为抗凝剂,属于一类葡聚糖,它可以与多种蛋白质相互作用,产生多种生物活性。
  32. GC17726 Otamixaban Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂,可有效抑制游离和凝血酶原结合的 fXa。
  33. GC12839 Edoxaban tosylate monohydrate A potent inhibitor of Factor Xa
  34. GC11644 Edoxaban Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的因子 Xa (FXa) 抑制剂,对游离人 FXa 和凝血酶原酶的 Ki 值分别为 0.561 和 2.98 nM。
  35. GC12875 Dabigatran ethyl ester 达比加群乙酯是一种新兴的口服抗凝剂,是凝血酶活性的直接抑制剂。
  36. GC15390 Dabigatran etexilate mesylate A prodrug form of dabigatran
  37. GC10448 Bivalirudin Trifluoroacetate A thrombin inhibitor
  38. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban 是 Rivaroxaban 的 (R)-对映异构体。
  39. GC13130 Apixaban An inhibitor of Factor Xa
  40. GC16293 BIBR 953 (Dabigatran, Pradaxa) A thrombin inhibitor
  41. GC10277 PPACK Dihydrochloride

    Thrombin inhibitor

  42. GC14502 AEBSF.HCl An irreversible serine protease inhibitor

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