Thrombin(凝血酶)
Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.
- Cat.No. 产品名称 Information
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GP26352
THBD Human
THBD Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 500 amino acids (22-515a
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GC62439
Edoxaban impurity 6
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GC62298
Edoxaban impurity 4
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GC19766
Heparin sodium salt (MW 15kDa)
肝素钠盐(MW 15kDa)(Sodium heparin (MW 15kDa))是肝素的聚合物,分子量为15kDa。
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GC61787
Dabigatran D4 hydrochloride
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GC61495
Thrombin (MW 37kDa)
凝血酶 (MW 37kDa) 是一种 Na+- 激活的变构丝氨酸蛋白酶。凝血酶诱导 ERK1 和 ERK2 的激活
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GC60240
Melagatran
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GC39515
TP508 TFA
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GC38332
Ximelagatran
A prodrug of melagatran, a thrombin inhibitor
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GC37785
Thrombin Inhibitor 2
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GC36792
Odiparcil
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GC35802
Dabigatran ethyl ester hydrochloride
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GC35528
Bivalirudin TFA
A thrombin inhibitor
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GC35384
Argatroban monohydrate
A thrombin inhibitor
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GP24824
Thrombin
人类凝血酶
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GC34373
Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride)
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GC34255
TP508
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GC34032
Napsagatran hydrate (Ro 46-6240 hydrate)
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GC32663
Desethyl KBT-3022
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GC32639
Thrombin inhibitor 1
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GC32619
OM-189
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GC32567
RWJ-445167 (3DP-10017)
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GC32554
Inogatran (H-314-27)
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GC18249
NQ301
A naphthoquinone with diverse biological activities
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GC17423
TS 155-2
An antihypertensive antibiotic
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GC17362
Metolazone
A thiazide-like diuretic
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GC10140
Thrombin Receptor Agonist Peptide
A peptide agonist of the α-thrombin receptor
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GC15180
BIBR-1048
A prodrug form of dabigatran
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GC11672
Argatroban
A thrombin inhibitor
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GC10398
Heparin sodium
肝素钠(Heparin sodium)作为抗凝剂,属于一类葡聚糖,它可以与多种蛋白质相互作用,产生多种生物活性。
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GC17726
Otamixaban
Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂,可有效抑制游离和凝血酶原结合的 fXa。
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GC12839
Edoxaban tosylate monohydrate
A potent inhibitor of Factor Xa
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GC11644
Edoxaban
Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的因子 Xa (FXa) 抑制剂,对游离人 FXa 和凝血酶原酶的 Ki 值分别为 0.561 和 2.98 nM。
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GC12875
Dabigatran ethyl ester
达比加群乙酯是一种新兴的口服抗凝剂,是凝血酶活性的直接抑制剂。
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GC15390
Dabigatran etexilate mesylate
A prodrug form of dabigatran
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GC10448
Bivalirudin Trifluoroacetate
A thrombin inhibitor
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GC11101
5-R-Rivaroxaban
5-R-Rivaroxaban 是 Rivaroxaban 的 (R)-对映异构体。
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GC13130
Apixaban
An inhibitor of Factor Xa
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GC16293
BIBR 953 (Dabigatran, Pradaxa)
A thrombin inhibitor
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GC10277
PPACK Dihydrochloride
Thrombin inhibitor
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GC14502
AEBSF.HCl
An irreversible serine protease inhibitor