Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Products for Chromatin/Epigenetics
- Bromodomain(43)
- Aurora Kinase(54)
- DNA Methyltransferase(30)
- HDAC(160)
- Histone Acetyltransferases(59)
- Histone Demethylases(84)
- Histone Methyltransferase(185)
- HIF(80)
- JAK(130)
- MBT Domains(1)
- PARP(86)
- Pim(27)
- Protein Ser/Thr Phosphatases(31)
- RNA Polymerase(6)
- Sirtuin(60)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(17)
- Epigenetic Reader Domain(184)
- MicroRNA(12)
- Chromodomain(1)
- Citrullination(15)
- DNA/RNA Demethylation(1)
- DNA/RNA Methylation(6)
- Histone Deacetylation(38)
- Histones/Histone Peptides(7)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Cat.No. 产品名称 Information
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GC25992
TG-89
TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM.
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GC25940
SNS-314
SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
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GC25869
RO495
RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).
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GC25580
LLY-284
LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.
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GC25552
KT-531
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
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GC25483
GSK3368715 (EPZ019997) 3HCl
GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.
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GC25305
CPI-455 HCl
CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
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GC25304
CP2
CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
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GC25168
Brepocitinib (PF-06700841)
Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
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GC25159
BMF-219
BMF-219 is a novel, potent, irreversible menin inhibitor, can be used in the treatment of leukemia.
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GC25139
Biphenyl-4-sulfonyl chloride
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
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GC67984
Alteminostat
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GC67962
Simmiparib
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GC67941
HIF-PHD-IN-1
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GC67934
EEDi-5285
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GC67921
Bomedemstat ditosylate
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GC67912
Amredobresib
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GC67906
OM-153
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GC67899
Aurora kinase inhibitor-8
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GC67873
PAD-IN-2
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GC67867
VVD-118313
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GC67863
DDO-2093 dihydrochloride
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GC67778
Sirtuin modulator 3
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GC67758
MM-401 TFA
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GC67676
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
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GC67674
CRA-026440 hydrochloride
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GC52479
Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)
A biotinylated peptide fragment of histone H3
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GC52371
Vimentin (G146R) (139-159)-biotin Peptide
A biotinylated mutant vimentin peptide
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GC52370
Citrullinated Vimentin (R144) (139-159)-biotin Peptide
A biotinylated and citrullinated vimentin peptide
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GC52368
DL-Sulforaphane Glutathione
A metabolite of sulforaphane
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GC52367
Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide
A biotinylated and citrullinated mutant vimentin peptide
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GC52364
Vimentin (139-159)-biotin Peptide
A biotinylated vimentin peptide
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GC52363
Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide
A biotinylated and citrullinated histone H3 peptide
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GC52351
Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide
A biotinylated and citrullinated α-enolase peptide
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GC66464
HIF-1α-IN-2
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GC66441
BRD4/CK2-IN-1
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GC66379
AFM-30a hydrochloride
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GC66335
PAD2-IN-1 hydrochloride
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GC66329
NDI-034858
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GC66067
ODM-207
ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.
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GC66055
5-Phenylpentan-2-one
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GC66052
HDAC-IN-40
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GC66049
NSC 694621
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GC66026
SIRT2-IN-9
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GC65980
EZH2-IN-13
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GC65965
MPT0E028
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GC65962
Dot1L-IN-5
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GC65927
PARP-2-IN-1
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GC65918
AS-85
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GC65907
KSQ-4279