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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC25992 TG-89 TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM.
  3. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  4. GC25869 RO495 RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).
  5. GC25580 LLY-284 LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.
  6. GC25552 KT-531 KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
  7. GC25483 GSK3368715 (EPZ019997) 3HCl GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.
  8. GC25305 CPI-455 HCl CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
  9. GC25304 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
  10. GC25168 Brepocitinib (PF-06700841) Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
  11. GC25159 BMF-219 BMF-219 is a novel, potent, irreversible menin inhibitor, can be used in the treatment of leukemia.
  12. GC25139 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
  13. GC67984 Alteminostat
  14. GC67962 Simmiparib
  15. GC67941 HIF-PHD-IN-1
  16. GC67934 EEDi-5285
  17. GC67921 Bomedemstat ditosylate
  18. GC67912 Amredobresib
  19. GC67906 OM-153
  20. GC67899 Aurora kinase inhibitor-8
  21. GC67873 PAD-IN-2
  22. GC67867 VVD-118313
  23. GC67863 DDO-2093 dihydrochloride
  24. GC67778 Sirtuin modulator 3
  25. GC67758 MM-401 TFA
  26. GC67676 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
  27. GC67674 CRA-026440 hydrochloride
  28. GC52479 Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt) A biotinylated peptide fragment of histone H3
  29. GC52371 Vimentin (G146R) (139-159)-biotin Peptide A biotinylated mutant vimentin peptide
  30. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide A biotinylated and citrullinated vimentin peptide
  31. GC52368 DL-Sulforaphane Glutathione A metabolite of sulforaphane
  32. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide A biotinylated and citrullinated mutant vimentin peptide
  33. GC52364 Vimentin (139-159)-biotin Peptide A biotinylated vimentin peptide
  34. GC52363 Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide

    A biotinylated and citrullinated histone H3 peptide
  35. GC52351 Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide A biotinylated and citrullinated α-enolase peptide
  36. GC66464 HIF-1α-IN-2
  37. GC66441 BRD4/CK2-IN-1
  38. GC66379 AFM-30a hydrochloride
  39. GC66335 PAD2-IN-1 hydrochloride
  40. GC66329 NDI-034858
  41. GC66067 ODM-207 ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.
  42. GC66055 5-Phenylpentan-2-one
  43. GC66052 HDAC-IN-40
  44. GC66049 NSC 694621
  45. GC66026 SIRT2-IN-9
  46. GC65980 EZH2-IN-13
  47. GC65965 MPT0E028
  48. GC65962 Dot1L-IN-5
  49. GC65927 PARP-2-IN-1
  50. GC65918 AS-85
  51. GC65907 KSQ-4279

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