HIF(缺氧诱发因素)
Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.
- Cat.No. 产品名称 Information
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GC67941
HIF-PHD-IN-1
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GC66464
HIF-1α-IN-2
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GC65570
HIF1-IN-3
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GC65333
PT2399
PT2399 is a potent and orally available antagonist of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β.
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GC65133
(S,R,S)-AHPC-C5-COOH
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GC65046
M1002
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GC64945
M1001
M1001 is a weak agonist of hypoxia-inducible factor-2α (HIF-2α) that binds to the HIF-2α PAS-B domain with Kd of 667 nM.
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GC64584
PHD-1-IN-1
PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM
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GC64001
TRC160334
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GC63828
Izilendustat
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GC63678
HIF-2α-IN-4
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GC49190
Roxadustat-d5
An internal standard for the quantification of roxadustat
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GC49062
Tiopronin-d3
An internal standard for the quantification of tiopronin
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GC62584
HIF-2α-IN-2
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GC62418
HIF-2α-IN-3
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GC62406
Moracin O
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GC62354
Acriflavine hydrochloride
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GC62277
AKB-6899
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GC61949
1,4-DPCA ethyl ester
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GC61863
Verucopeptin
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GC61669
Ethyl 3,4-dihydroxybenzoate
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GC60919
Hydroxycitric acid tripotassium hydrate
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GC50537
FM19G11
FM19G11 是一种低氧诱导因子-1-α (HIF-1α) 抑制剂,在 HeLa 细胞中抑制低氧诱导的荧光素酶活性,IC50 为 80 nM。
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GC50211
TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY 是 HIF-1 异二聚化的环肽抑制剂,可抑制癌细胞中的缺氧信号传导。 TAT-cyclo-CLLFVY 破坏 HIF-1α/HIF-1β 蛋白质-蛋白质相互作用,IC50 为 1.3 μM。
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GC50128
TC-S 7009
An inhibitor of HIF-2α PAS-B domain heterodimerization
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GC39146
HIF-1 inhibitor-1
An inhibitor of HIF-1 signaling
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GC38767
Deoxyshikonin
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GC38044
Fraxinellone
A liminoid degradant with diverse biological activities
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GC37966
ZINC13466751
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GC37889
VCE-004.8
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GC37801
TM6089
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GC37066
Rac-PT2399
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GC37034
PT2977
PT2977 (Belzutifan, MK-6482), an orally active and selective HIF-2α inhibitor, increases potency and improves pharmacokinetic profile, providing a potential treatment for clear cell renal cell carcinoma (ccRCC).
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GC35230
Acetylarenobufagin
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GC42785
Amifostine (hydrate)
A broad-spectrum radioprotective thiol
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GC41625
Oroxylin A
A flavonoid with diverse biological activities
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GC41572
PRLX-93936
An erastin analog with antitumor activity
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GC40918
Gramicidin A
A channel-forming ionophore
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GC34595
GN44028
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GC33634
Enarodustat (JTZ-951)
A pan HIF-PH inhibitor
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GC33416
AFP464
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GC33170
ENMD-119 (ENMD 1198)
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GC33043
EL-102
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GC32948
IDF-11774
IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
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GC32945
THS-044
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GC32876
SYP-5
A HIF-1 inhibitor
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GC32724
LW6 (HIF-1α inhibitor)
A novel inhibitor of HIF1α protein accumulation and transcription
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GC32680
PT-2385
PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.
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GC32449
Desidustat
An inhibitor of HIF-PH
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GC32228
Tilorone dihydrochloride
An interferon-inducing antiviral agent