Cell Cycle/Checkpoint

Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more
Products for Cell Cycle/Checkpoint
- ATM/ATR(27)
- Aurora Kinase(53)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(18)
- CRM1(9)
- Cyclin-Dependent Kinases(82)
- E1 enzyme(1)
- G-quadruplex(8)
- Haspin(5)
- HMTase(1)
- Kinesin(24)
- Ksp(4)
- Microtubule/Tubulin(198)
- Mps1(14)
- Mitotic(7)
- RAD51(10)
- ROCK(59)
- Rho(13)
- PERK(7)
- PLK(34)
- PTEN(6)
- Wee1(6)
- PAK(19)
- Arp2/3 Complex(8)
- Dynamin(7)
- ECM & Adhesion Molecules(37)
- Cytoskeleton & Motor Proteins(45)
- Endomembrane System & Vesicular Trafficking(24)
- G1(36)
- Genotoxic Stress(16)
- G2/M(25)
- G2/S(8)
- Inositol Phosphates(18)
- Proteolysis(93)
- Cellular Chaperones(3)
- Cat.No. Product Name Information
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GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
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GC41676
(±)-Nornicotine
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist.
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GC49482
(±)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine
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GC41684
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups.
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GC40802
(±)12(13)-DiHOME
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
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GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
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GC45890
(+)-Abscisic Acid-d6
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GC62728
(1E)-CFI-400437 dihydrochloride
(1E)-CFI-400437 dihydrochloride 是一种有效的 PLK4 (IC50= 0.6 nM),并对 PLK 家族的其他成员有选择性 (>10 μM)。(1E)-CFI-400437 dihydrochloride 抑制 Aurora A、 Aurora B、 KDR 和 FLT-3,IC50 分别为 0.37、0.21、0.48 和 0.18 μM。具有抗增殖活性。
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GC41268
(E)-2-Hexadecenal
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase.
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GC41701
(E)-2-Hexadecenal Alkyne
(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
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GC46335
(E)-Fenpyroximate
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GC10419
(R)-CCG-1423
Rho inhibitor
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GC16429
(R)-DRF053 dihydrochloride
cdk/CK1 inhibitor,potent and ATP-competitive
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GC41719
(R)-nitro-Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin.
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GC46347
(S)-(+)-Methoprene
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GC41557
(S)-3'-amino Blebbistatin
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC41484
(S)-3'-hydroxy Blebbistatin
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC14497
(S)-CCG-1423
Rho inhibitor
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GC34999
(S)-Ceralasertib
(S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。
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GC46351
(S)-CR8
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GC41737
(S)-Glycyl-H-1152 (hydrochloride)
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
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GC40145
(S)-Laudanosine
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
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GC41739
(S)-nitro-Blebbistatin
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC18275
1,2-Dihexadecyl-sn-glycero-3-PC
1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions.
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GC45783
1,2-Dioleoyl-rac-glycerol-13C3
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GC46379
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
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GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
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GC46385
1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose
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GC19528
1,4-Benzoquinone
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GC18726
1-Methyl-1,4-dihydronicotinamide
1-Methyl-1,4-dihydronicotinamide is a derivative of nicotinamide .
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GC49736
10-acetyl Docetaxel
A derivative of paclitaxel and an inhibitor of microtubule depolymerization
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GC12954
10-DAB (10-Deacetylbaccatin)
Precursor of antitumor compound Palitaxel and Docetaxel
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GC35044
10-Deacetyl-7-xylosyl paclitaxel
10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。
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GC35045
10-Oxo Docetaxel
10-Oxo Docetaxel (Docetaxel Impurity 1) 是新型紫杉烷,具有明显的抗肿瘤活性,是多西他赛(docetaxel)的中间体。
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GC17295
10058-F4
C-Myc-Max dimerization inhibitor
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GC63576
10074-A4
10074-A4 是一种 c-Myc 抑制剂,可以在肽链的不同位点与 c-Myc370-409 结合。10074-A4 具有抗癌作用。
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GC14918
10074-G5
c-Myc inhibitor
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GC40448
12(S)-HETE
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
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GC46434
13C15-Nivalenol
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GC49390
13C6-4-Nitroaniline
An internal standard for the quantification of 4-nitroaniline
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GC41110
16-epi Latrunculin B
16-epi Latrunculin B, first isolated from the Red Sea sponge N.
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GC48423
19-O-Acetylchaetoglobosin A
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GC42151
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis.
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GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.
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GC45324
2,5-dimethyl Celecoxib
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GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
A food-derived carcinogen
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GC40675
2-deoxy-Artemisinin
2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
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GC15084
2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
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GC42161
2H-Cho-Arg (trifluoroacetate salt)
2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
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GC40618
3',4',7-Trihydroxyisoflavone
3',4',7-Trihydroxyisoflavone is a natural isoflavonoid that has antioxidant activity.