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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Cyclin-Dependent Kinases

Cyclin-Dependent Kinases(细胞周期蛋白依赖性激酶)

Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.

Products for  Cyclin-Dependent Kinases

  1. Cat.No. 产品名称 Information
  2. GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
  3. GC15841 Alsterpaullone

    阿特波龙,9-Nitropaullone,NSC 705701

     A dual CDK and GSK3 inhibitor
  4. GC16520 Olomoucine

    2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤

     An inhibitor of cyclin-dependent kinases
  5. GC15215 Iso-Olomoucine

    异奥罗莫星

     An inactive stereoisomer of olomoucine
  6. GC14294 Cdk1/2 Inhibitor III

    Cyclin-dependent kinase 1/2 Inhibitor III

     A cell-permeable inhibitor of Cdk1 and Cdk2
  7. GC11564 Cdk4/6 Inhibitor IV

    CINK4

     A cell-permeable inhibitor of Cdk4/6
  8. GC15607 ON123300

    8-环戊基-7,8-二氢-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-7-氧代-吡啶并[2,3-D]嘧啶-6-甲腈,ON123300

     A multi-kinase inhibitor
  9. GC14002 Bohemine A Cdk inhibitor
  10. GC15173 PD 0332991 (Palbociclib)

    帕布昔利布（palbociclib）,PD0332991;PD-0332991;PD 0332991

     PD 0332991 (Palbociclib) (PD 0332991) 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 PD 0332991 (Palbociclib) 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
  11. GC18051 CCT251545 analogue, Compound 51

    Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
  12. GC16420 THZ531 An inhibitor of Cdk12 and Cdk13
  13. GC14230 K03861

    AUZ454或者K03861,K03861

     K03861 (K03861) 是一种 II 型 CDK2 抑制剂，Kd 为 8.2 nM。 K03861 (K03861) 通过与活化细胞周期蛋白的结合竞争抑制 CDK2 活性。
  14. GC16545 GX-674 GX-674 是一种有效的、状态依赖性、异构体选择性电压门控钠通道 1.7 (Nav1.7) 拮抗剂，在 -40 mV 时的 IC50 为 0.1 nM。
  15. GC13511 THZ2 A Cdk7 inhibitor
  16. GC12826 AZD-5597

    [4-[[5-氟-4-[2-甲基-1-(1-甲基乙基)-1H-咪唑-5-基]-2-嘧啶基]氨基]苯基][(3S)-3-(甲氨基)-1-吡咯烷]甲酮

    Potent CDK inhibitor
  17. GC14707 Purvalanol A

    NG-60

     A selective inhibitor of cyclin-dependent kinases
  18. GC12348 Ro 3306

    2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮

     Ro 3306是一种ATP竞争性抑制剂，主要靶向CDK1/cyclin B1（Ki值为35nmol/L）和CDK1/cyclin A复合物（Ki值为110nmol/L）。
  19. GC11971 LY2857785 A Cdk9 inhibitor
  20. GC17067 LDC000067

    (3-(6-(2-甲氧基苯基)嘧啶-4-基氨基)苯基)甲烷磺酰胺,LDC067

     A Cdk9 inhibitor
  21. GC11944 PF 4800567 hydrochloride A selective CK1ε inhibitor
  22. GC16413 TMCB

    4,5-二氢-N-(2,3,5,6-四溴-4-甲氧基苯基)-1H-咪唑-2-甲酰胺

     A dual inhibitor of CK2 and ERK8
  23. GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
  24. GC17150 Ryuvidine

    Cdk4 Inhibitor III, Cyclic-dependent Kinase 4 Inhibitor III, SPS812

     An inhibitor of SETD8
  25. GC12886 NSC 625987

    Cdk4 Inhibitor II

     A Cdk4/cyclin D1 complex inhibitor
  26. GC11410 Aminopurvalanol A

    NG 97

     A selective CDK inhibitor
  27. GC11634 NSC 693868

    1H-吡唑并[3,4-B]喹喔啉-3-胺,Cdk1/5 Inhibitor

     A selective inhibitor of Cdk1 and Cdk5
  28. GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1
  29. GC13649 Arcyriaflavin A A CDK4 and CAMKII inhibitor
  30. GC14182 Kenpaullone

    克莱拉尼,9-Bromopaullone; NSC-664704

     A inhibitor of cyclin-dependent kinase and GSK3β
  31. GC12642 THZ1 Hydrochloride A covalent Cdk7 inhibitor
  32. GC14162 ML167

    5-[4-[[(5-甲基-2-呋喃基)甲基]氨基]-6-喹唑啉基]-2-呋喃甲醇,CID44968231; NCGC00188654

     A selective Clk4 inhibitor
  33. GC10840 THZ1 A covalent Cdk7 inhibitor
  34. GC15377 LEE011 succinate

    瑞博西尼琥珀酸盐; LEE011 succinate

     A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  35. GC15922 LEE011 hydrochloride

    瑞博西尼盐酸盐; LEE011 hydrochloride

     A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  36. GC11785 CDK4 inhibitor

    瑞博西尼

     An antiproliferative cyclin D1/Cdk4 inhibitor
  37. GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
  38. GC16000 WHI-P180

    3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚,Janex 3

     A multi-kinase inhibitor
  39. GC17400 R547

    [4-氨基-2-[(1-甲磺酰基哌啶-4-基)氨基]嘧啶-5-基](2,3-二氟-6-甲氧基苯基)甲酮

     A selective Cdk inhibitor
  40. GC10842 LEE011

    瑞博西尼; LEE011

     A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  41. GC16425 Flavopiridol hydrochloride

    (-)-2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]-4H-1-苯并吡喃-4-酮盐酸盐,Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride

     An inhibitor of cyclin-dependent kinases
  42. GC11835 Deferasirox

    地拉罗司; ICL 670

     Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。
  43. GC16268 Purvalanol B

    (2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇,NG 95; NG95; NG-95

     A CDK inhibitor
  44. GC17648 Dinaciclib(SCH727965)

    (2S)-1-[3-乙基-7-[[(1-氧代-3-吡啶基)甲基]氨基]吡唑并[1,5-A]嘧啶-5-基]-2-哌啶乙醇,SCH 727965

     A CDK inhibitor
  45. GC12865 BMS265246 A cell-permeable inhibitor of Cdk1 and Cdk2
  46. GC15588 PHA-848125

    PHA-848125

     An inhibitor of Cdks
  47. GC15421 Palbociclib (PD0332991) Isethionate

    帕博西尼羟乙基磺酸盐; PD 0332991 isethionate

     Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
  48. GC12438 AZD-5438

    4-[2-甲基-1-异丙基-1H-咪唑-5-基]-N-[4-(甲磺酰基)苯基]-2-嘧啶胺,AZD 5438;AZD5438

     A potent inhibitor of CDKs
  49. GC17935 PD 0332991 (Palbociclib) HCl

    帕布昔利布盐酸盐,PD0332991;PD-0332991;PD 0332991

     PD 0332991 作为 CDK4 和 CDK6 激酶的口服活性强效和高选择性抑制剂，可以在低纳摩尔浓度下阻断 pRb 磷酸化并随后在敏感细胞系中诱导 G1 期停滞。
  50. GC16822 LY2835219

    Abemaciclib; LY2835219 methanesulfonate

     LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC50 分别为 2nM 和 10nM。
  51. GC15963 Nu 6027 A CDK and ATR inhibitor

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