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Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC49460 ING-2 AM A cell-permeable fluorescent sodium indicator
  3. GC63774 MMAF-d8 hydrochloride D8-MMAF hydrochloride是MMAF hydrochloride的氘代形式。
  4. GC63740 PF-06380101-d8 PF-06380101 D8 (Aur0101 D8) 是 PF-06380101 的氘代物。PF-06380101 是一种 Auristatin 微管抑制剂,是一种细胞毒性 Dolastatin 10 类似物。
  5. GC63716 Sovesudil hydrochloride Sovesudil (PHP-201) hydrochloride 是一种有效的、ATP 竞争性局部作用 Rho 激酶 (ROCK) 抑制剂,对 ROCK I 和 ROCK II 的 IC50 分别为 3.7和2.3 nM。Sovesudil hydrochloride 可降低眼压而不引起充血。
  6. GC63663 Avanbulin Avanbulin (BAL27862) 是一种有效的秋水仙碱位点结合的微管蛋白 (tubulin) 装配抑制剂。Avanbulin 在 37 °C 抑制微管蛋白组装 (IC50=1.4 μM)。Avanbulin 与微管蛋白结合的 Kd 值为 244 nM。Avanbulin 可用于癌症和细胞分裂的研究。
  7. GC63596 Fmoc-MMAE Fmoc-MMAE 是保护基团共轭连接到 MMAE。Mc-MMAE 是有效的微管蛋白抑制剂,可用于偶联抗体。
  8. GC63576 10074-A4 10074-A4 是一种 c-Myc 结合化合物,与 c-Myc370–409 结合,表现得像“蛋白质云”周围的“配体云”,具有与非结合配体截然不同的特征。具有抗癌作用
  9. GC63461 MMAE-d8 D8-MMAE (D8-Monomethyl auristatin E) 是氘代标记的 MMAE。MMAE 是一种 tubulin 抑制剂,抑制有丝分裂。
  10. GC63351 Sovesudil Sovesudil (PHP-201) 是一种有效的、ATP 竞争性局部作用 Rho激酶 (ROCK) 抑制剂,对 ROCK I 和 ROCK II 的 IC50 分别为 3.7 和 2.3 nM。Sovesudil 降低眼压而不引起充血。
  11. GC63333 Cotosudil Cotosudil 是一种 ROCK 激酶抑制剂,可用于青光眼或高眼压症的研究。
  12. GC63253 Verosudil Verosudil (AR-12286) 是一种有效的 Rho 激酶 (ROCK) 抑制剂,对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 主要通过增加眼房水通过小梁网流出来降低眼压。
  13. GC63211 Tau tracer 2 Tau tracer 2 (Pl-2620) 是一种 Tau 示踪剂,用于 Tau 蛋白聚集体成像。Tau tracer 2 可用于诊断神经退行性疾病。
  14. GC63165 RAD51-IN-1 RAD51-IN-1 是 B02 的衍生物,是 RAD51 的有效抑制剂。 RAD51-IN-1 可用于癌症研究。
  15. GC62728 (1E)-CFI-400437 dihydrochloride CFI-400437 is a potent and selective polo-like kinase 4 (PLK4) inhibitor.
  16. GC49437 Gliotoxin-13C13 An internal standard for the quantification of gliotoxin
  17. GC49430 Wee1 Inhibitor An inhibitor of Wee1
  18. GC49419 Aniline-d5 An internal standard for the quantification of aniline
  19. GC49412 NSC 756093 An inhibitor of the GBP1-Pim-1 protein-protein interaction
  20. GC49404 Paclitaxel C A taxoid and an inhibitor of microtubule depolymerization
  21. GC49394 N-Nitroso Fluoxetine A derivative of fluoxetine
  22. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
  23. GC49390 13C6-4-Nitroaniline An internal standard for the quantification of 4-nitroaniline
  24. GC49387 Berberine-d6 (chloride) An internal standard for the quantification of berberine
  25. GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline A food-derived carcinogen
  26. GC49353 N-Nitroso Metoprolol A genotoxic derivative of metoprolol
  27. GC49351 N-Nitroso Atenolol A genotoxic derivative of (±)-atenolol
  28. GC49345 Coelenterazine hcp A synthetic bioluminescent luciferin
  29. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
  30. GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
  31. GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor
  32. GC49305 H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt) An RGD-containing tetrapeptide
  33. GC49293 Dichlorvos-d6 An internal standard for the quantification of dichlorvos
  34. GC49280 GSK579289A A Plk1 inhibitor
  35. GC49244 4-oxo Isotretinoin An active metabolite of isotretinoin
  36. GC49205 L-Leu-AMC (hydrochloride) A fluorogenic substrate for leucine aminopeptidase
  37. GC49204 Nefazodone-d6 (hydrochloride) An internal standard for the quantification of nefazodone
  38. GC49186 O-Demethyl Apremilast An active metabolite of apremilast
  39. GC49163 N’-Nitrosonornicotine An N-nitrosamine and a carcinogen
  40. GC49145 Z-FR-AMC (trifluoroacetate salt) A fluorogenic substrate for cathepsin L
  41. GC49142 Isorhoifolin A flavonoid glycoside with diverse biological activities
  42. GC49128 Phenylbutazone-d9 An internal standard for the quantification of phenylbutazone
  43. GC49124 EN219 An RNF114 recruiter
  44. GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
  45. GC49093 Safflower Red A red pigment with diverse biological activities
  46. GC49089 FR900359 A cyclic depsipeptide and an inhibitor of Gαq, Gα11, and Gα14
  47. GC49077 Podophyllotoxin-d6 An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin
  48. GC49072 Tribenoside A vasoprotective agent
  49. GC49065 Metacetamol A derivative of acetaminophen
  50. GC49042 Benastatin A A bacterial metabolite with diverse biological activities
  51. GC49024 Palmitic Acid MaxSpec® Standard A long-chain saturated fatty acid

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