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PLK(Polo样激酶)

PLK (Polo-like kinase 1) is a serine/threonine-protein that are implicated in cell cycle, mitosis, cytokinesis and DNA damage etc.

  1. Cat.No. 产品名称 Information
  2. GC65189 PLK4-IN-1
  3. GC62728 (1E)-CFI-400437 dihydrochloride CFI-400437 is a potent and selective polo-like kinase 4 (PLK4) inhibitor.
  4. GC49280 GSK579289A A Plk1 inhibitor
  5. GC62174 ON1231320 ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis.
  6. GC37726 TAK-960 hydrochloride A selective inhibitor of polo-like kinase 1
  7. GC37725 TAK-960 dihydrochloride A selective inhibitor of polo-like kinase 1
  8. GC37601 SBE13 A potent Plk1 inhibitor
  9. GC35660 CFI-400945 free base
  10. GC35216 AAPK-25
  11. GC32751 Centrinone-B (LCR-323)
  12. GC32688 Centrinone (LCR-263) A Plk4 inhibitor
  13. GC13606 CFI-400945

    orally available, selective inhibitor of polo-like kinase 4 (PLK4)

  14. GC14186 3MB-PP1 An inhibitor of analog-sensitive Plk1 alleles
  15. GC10773 TAK960 A selective inhibitor of polo-like kinase 1
  16. GC14644 SBE 13 HCl A potent Plk1 inhibitor
  17. GC14857 LFM-A13 A BTK inhibitor
  18. GC13268 Cyclapolin 9 Cyclapolin 9 是一种有效的、选择性的和 ATP 竞争性的 polo 样激酶 1 (PLK1) 抑制剂,IC50 为 500 nM。 Cyclapolin 9 对其他激酶无活性。
  19. GC16771 TC-S 7005 TC-S 7005 是一种 Polo 样激酶 (Plks) 抑制剂,对 Plk2、Plk3 和 Plk1 的 IC50 分别为 4 nM、24 nM 和 214 nM。
  20. GC12515 NMS-1286937 An inhibitor of Plk1
  21. GC14735 Poloxime Poloxime 是 poloxin 的水解产物,是一种非 ATP 竞争性 Plk1 抑制剂,具有中等的 Plk1 抑制活性。
  22. GC15745 Mps1-IN-2 An inhibitor of Mps1
  23. GC12415 Rigosertib Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂,通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡,促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂,IC50 为 9 nM。
  24. GC13580 Rigosertib sodium Rigosertib sodium (ON-01910 sodium) 是一种多激酶抑制剂和选择性抗癌剂,通过抑制 PI3K/Akt 通路诱导细胞凋亡,促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib sodium 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂,IC50 为 9 nM。
  25. GC13903 Ro3280 A selective Plk1 inhibitor
  26. GC10163 MLN0905 A Plk1 inhibitor
  27. GC11224 BI6727(Volasertib) A polo-like kinase inhibitor
  28. GC12338 Wortmannin An irreversible PI3K inhibitor
  29. GC12335 GSK461364 A reversible inhibitor of Plk1
  30. GC13928 HMN-214 A prodrug form of HMN-176
  31. GC14358 Rigosertib (ON-01910,Estybon) A potent inhibitor of Plk1
  32. GC12450 BI 2536 A potent inhibitor of Plk1
  33. GC13543 Poloxin An inhibitor of the Plk1 polo-box domain
  34. GC11621 GW843682X A reversible polo-like kinase inhibitor

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