Wee1(Wee1蛋白激酶)

Wee1 is a tyrosine kinase nuclear protein that catalyzes tyrosine phosphorylation of CDC2/Cyclin B kinase. It negatively regulates the entry to mitosis by protecting nucleus from cytoplasmically activated CDC2 kinase.

Products for Wee1

Cat.No. 产品名称 Information
GC72924 PD173952 PD173952是一种酪氨酸激酶抑制剂，对Lyn、Abl和Csk的ic50分别为0.3、1.7和6.6 nM。
GC71010 RSS0680 RSS0680（实施例22）是一种靶向激酶蛋白质降解的双功能化合物。
GC65994 WEE1-IN-5 Debio 0123 is an inhibitor of Wee1 kinase which is a key regulator of the G2/M and S phase checkpoints.
GC62697 ZN-c3 ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.
GC62449 WEE1-IN-3 WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。
GC50045 PD 166285 dihydrochloride
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
A tyrosine kinase inhibitor
GC32853 PD0166285
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.
GC16030 MK-1775
MK1775,MK 1775
MK-1775 是一种有效的选择性 Wee1 激酶小分子抑制剂，IC50 值为 5.2 nM。