Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information

GP26200 TYRO3 Mouse TYRO3 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 628 amino acids (31-419 aa) and having a molecular mass of 68

GP26187 ErbB4 Human ErbB4 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 863 amino acids (26-649 a

GC26063 WAY-340935 WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein.

GC26021 UNC2025 HCl UNC2025 HCl is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.

GC26001 TPX-0046 TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay

GC25969 SU5208 SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2).

GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

GC25787 PRT-060318 2HCl PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.

GC25669 Nilotinib hydrochloride Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

GC25559 Lapatinib (GW-572016) Ditosylate Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

GC25367 Ehp-inhibitor-1 Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.

GC25313 CS-2660 (JNJ-38158471) CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

GC25219 CH7233163 CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.

GC25092 Apatinib (YN968D1) mesylate Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.

GC25017 4,4'-Bis(4-aminophenoxy)biphenyl 4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production.

GC25000 (E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

GC67998 Insulin degludec

GC67948 Cabozantinib-d6

GC67917 RET-IN-7

GC67879 Edecesertib

GC67878 TL4830031

GC67860 JBJ-09-063 TFA

GC67774 CT52923

GC67759 Lapatinib-d4

GC67749 Amivantamab

GC67690 JBJ-09-063 hydrochloride

GC52516 Erbstatin A tyrosine kinase inhibitor

GC52472 Inostamycin A (sodium salt) A bacterial metabolite with anticancer activity

GC66476 DDR1-IN-6

GC66451 AKN-028 acetate

GC66432 EAI001

GC66428 EGFR-IN-5

GC66405 Panitumumab Panitumumab (anti-EGFR, ABX-EGF) is a recombinant, fully human IgG2 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR).

GC66385 Tovetumab

GC66349 Mavrilimumab

GC66333 Panitumumab (anti-EGFR)

GC66327 Zilovertamab

GC66043 VEGFR-2-IN-29

GC66028 c-Fms-IN-13

GC65992 FGFR2-IN-3

GC65991 FGFR2-IN-3 hydrochloride

GC65984 FLT3-IN-16

GC65976 cFMS Receptor Inhibitor IV

GC65974 EGFR-IN-9

GC65966 BPI-9016M

GC65953 RORγt inverse agonist 23

GC65948 c-Kit-IN-5-1 AMG-25 is a novel potent and selective c-Kit inhibitor.

GC65941 HS-276 HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA).

GC65894 ABN401

GC65886 BI-853520