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Home >> Signaling Pathways >> Tyrosine Kinase >> IRAK

IRAK(白细胞介素受体相关激酶)

Interleukin receptor-associated kinase (IRAK) is a family of serine/threonine-protein kinase that plays a vital role in innate immune immunity. It is involved in the TLR and IL-1R signaling pathways which associated with the autoimmune and inflammatory diseases.

  1. Cat.No. 产品名称 Information
  2. GC67879 Edecesertib
  3. GC65941 HS-276 HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA).
  4. GC63925 JH-X-119-01 JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.
  5. GC63263 Zabedosertib Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential, which is a protein kinase involved in signaling innate immune responses from Toll-like receptors.
  6. GC62583 IRAK-4 protein kinase inhibitor 2 IRAK-4 protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM.
  7. GC62429 HS271
  8. GC62197 PROTAC IRAK4 degrader-1
  9. GC61944 IRAK4-IN-6
  10. GC46013 AS-2444697 (hydrochloride) An IRAK4 inhibitor
  11. GC38799 IRAK4-IN-4 IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
  12. GC36328 IRAK inhibitor 4 trans
  13. GC33054 AZ1495 AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively.
  14. GC32748 CA-4948 An IRAK-4 inhibitor
  15. GC31688 IRAK4-IN-1 IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.
  16. GC19287 PF06650833 PF06650833 (PF-06650833) 是一种有效的、选择性的和口服活性的白细胞介素 1 受体相关激酶 4 (IRAK4) 抑制剂，在细胞和 PBMC 试验中的 IC50 分别为 0.2 和 2.4 nM。
  17. GC15999 IRAK-1-4 Inhibitor I A benzimidazole
  18. GC17371 IRAK inhibitor 6 An IRAK4 inhibitor
  19. GC16264 IRAK inhibitor 4 IRAK inhibitor 4 是一种白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂。
  20. GC11103 IRAK inhibitor 3 IRAK inhibitor 3 是一种从专利 WO2008030579 A2 中提取的白细胞介素-1 (IL-I) 受体相关激酶 (IRAK) 激酶调节剂。
  21. GC12651 IRAK inhibitor 2 IRAK inhibitor 2 是 IL-1 受体相关激酶抑制剂。
  22. GC17158 IRAK inhibitor 1 An IRAK4 inhibitor
  23. GN10156 Ginsenoside Rb1 A triterpene saponin with diverse biological activities

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