IRAK(白细胞介素受体相关激酶)
Interleukin receptor-associated kinase (IRAK) is a family of serine/threonine-protein kinase that plays a vital role in innate immune immunity. It is involved in the TLR and IL-1R signaling pathways which associated with the autoimmune and inflammatory diseases.
- Cat.No. 产品名称 Information
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GC67879
Edecesertib
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GC65941
HS-276
HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA).
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GC63925
JH-X-119-01
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.
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GC63263
Zabedosertib
Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential, which is a protein kinase involved in signaling innate immune responses from Toll-like receptors.
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GC62583
IRAK-4 protein kinase inhibitor 2
IRAK-4 protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM.
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GC62429
HS271
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GC62197
PROTAC IRAK4 degrader-1
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GC61944
IRAK4-IN-6
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GC46013
AS-2444697 (hydrochloride)
An IRAK4 inhibitor
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GC38799
IRAK4-IN-4
IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
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GC36328
IRAK inhibitor 4 trans
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GC33054
AZ1495
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively.
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GC32748
CA-4948
An IRAK-4 inhibitor
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GC31688
IRAK4-IN-1
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.
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GC19287
PF06650833
PF06650833 (PF-06650833) 是一种有效的、选择性的和口服活性的白细胞介素 1 受体相关激酶 4 (IRAK4) 抑制剂,在细胞和 PBMC 试验中的 IC50 分别为 0.2 和 2.4 nM。
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GC15999
IRAK-1-4 Inhibitor I
A benzimidazole
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GC17371
IRAK inhibitor 6
An IRAK4 inhibitor
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GC16264
IRAK inhibitor 4
IRAK inhibitor 4 是一种白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂。
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GC11103
IRAK inhibitor 3
IRAK inhibitor 3 是一种从专利 WO2008030579 A2 中提取的白细胞介素-1 (IL-I) 受体相关激酶 (IRAK) 激酶调节剂。
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GC12651
IRAK inhibitor 2
IRAK inhibitor 2 是 IL-1 受体相关激酶抑制剂。
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GC17158
IRAK inhibitor 1
An IRAK4 inhibitor
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GN10156
Ginsenoside Rb1
A triterpene saponin with diverse biological activities