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Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GP26352 THBD Human THBD Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 500 amino acids (22-515a
  3. GP26168 MMP9 Mouse MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
  4. GP26167 MMP2 Mouse MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
  5. GP26143 CTSZ Mouse, Active CTSZ Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 292 amino acids (23-306 aa) and having a molecular mass of32
  6. GP26142 CTSF Human, Sf9 CTSF produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 474 amino acids (20-484
  7. GC26092 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
  8. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
  9. GC25727 PF-06446846 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.
  10. GC25726 PF-05221304 PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).
  11. GC25723 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
  12. GC25536 JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.
  13. GC25337 D-Carnitine hydrochloride D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
  14. GC25188 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
  15. GC25117 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
  16. GC67997 Aminopeptidase-IN-1
  17. GC67993 (Rac)-Cotinine-d4
  18. GC67992 MLT-747
  19. GC67988 6-Hydroxybenzbromarone
  20. GC67978 Paltimatrectinib
  21. GC67976 D-Glucose-13C
  22. GC67975 Hexacosanoic acid-d4-1
  23. GC67973 L-Alanine-13C2
  24. GC67952 Hippuric acid-d5
  25. GC67951 5-Hydroxytryptophol-d4
  26. GC67947 Triolein 13C3
  27. GC67942 Stearic acid-d3
  28. GC67918 MPO-IN-1
  29. GC67916 Palmitic acid-d4
  30. GC67911 L-Serine-1-13C
  31. GC67910 L-Citrulline-13C
  32. GC67902 3-Amino-2-oxazolidinone-d4
  33. GC67898 GLS-1-IN-1
  34. GC67835 Glycocholic acid sodium
  35. GC67782 ALDH1A2-IN-1
  36. GC67781 Diaplasinin
  37. GC67771 GSK321
  38. GC67766 Abiraterone sulfate
  39. GC67761 (Z)-10-Hydroxynortriptyline-d3
  40. GC67751 Berotralstat dihydrochloride
  41. GC67731 S-(2-Carboxypropyl)-L-cysteine
  42. GC67701 Ulodesine
  43. GC67697 XZ426
  44. GC67693 Saccharopine hydrochloride
  45. GC67682 (S,S)-GSK321
  46. GC67670 L-Cysteine S-sulfate sodium hydrate
  47. GC52478 Telmisartan Acyl-β-D-Glucuronide (hydrate) A major metabolite of telmisartan
  48. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
  49. GC52368 DL-Sulforaphane Glutathione A metabolite of sulforaphane
  50. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt) A Bim-derived peptide
  51. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides

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