Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
Products for Proteases
- Aminopeptidase(18)
- ACE(65)
- Calpains(11)
- Carboxypeptidase(8)
- Cathepsin(47)
- DPP-4(18)
- Elastase(21)
- Gamma Secretase(42)
- HCV Protease(32)
- HSP(83)
- HIV Integrase(26)
- HIV Protease(32)
- MMP(168)
- NS3/4a protease(4)
- Serine Protease(11)
- Thrombin(41)
- Urokinase(2)
- Tyrosinases(37)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(11)
- Acyltransferase(53)
- Aldehyde Dehydrogenase (ALDH)(21)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(44)
- Drug Metabolite(446)
- E1/E2/E3 Enzyme(75)
- Endogenous Metabolite(1429)
- FABP(8)
- Farnesyl Transferase(20)
- Glutaminase(13)
- Glutathione Peroxidase(12)
- Isocitrate Dehydrogenase (IDH)(25)
- Lactate Dehydrogenase(16)
- Lipoxygenase(226)
- Mitochondrial Metabolism(197)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(11)
- Ser/Thr Protease(30)
- Tryptophan Hydroxylase(11)
- Xanthine Oxidase(16)
- MALT1(9)
- Caspase(78)
- PCSK9(1)
- Cat.No. 产品名称 Information
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GP26352
THBD Human
THBD Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 500 amino acids (22-515a
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GP26168
MMP9 Mouse
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
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GP26167
MMP2 Mouse
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
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GP26143
CTSZ Mouse, Active
CTSZ Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 292 amino acids (23-306 aa) and having a molecular mass of32
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GP26142
CTSF Human, Sf9
CTSF produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 474 amino acids (20-484
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GC26092
Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
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GC26017
UK-371804 HCl
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
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GC25727
PF-06446846
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.
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GC25726
PF-05221304
PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).
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GC25723
Perindopril L-Arginine
Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
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GC25536
JHU395
JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.
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GC25337
D-Carnitine hydrochloride
D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
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GC25188
Calcium 2-oxoglutarate
Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
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GC25117
Azvudine
Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
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GC67997
Aminopeptidase-IN-1
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GC67993
(Rac)-Cotinine-d4
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GC67992
MLT-747
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GC67988
6-Hydroxybenzbromarone
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GC67978
Paltimatrectinib
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GC67976
D-Glucose-13C
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GC67975
Hexacosanoic acid-d4-1
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GC67973
L-Alanine-13C2
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GC67952
Hippuric acid-d5
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GC67951
5-Hydroxytryptophol-d4
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GC67947
Triolein 13C3
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GC67942
Stearic acid-d3
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GC67918
MPO-IN-1
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GC67916
Palmitic acid-d4
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GC67911
L-Serine-1-13C
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GC67910
L-Citrulline-13C
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GC67902
3-Amino-2-oxazolidinone-d4
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GC67898
GLS-1-IN-1
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GC67835
Glycocholic acid sodium
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GC67782
ALDH1A2-IN-1
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GC67781
Diaplasinin
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GC67771
GSK321
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GC67766
Abiraterone sulfate
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GC67761
(Z)-10-Hydroxynortriptyline-d3
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GC67751
Berotralstat dihydrochloride
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GC67731
S-(2-Carboxypropyl)-L-cysteine
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GC67701
Ulodesine
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GC67697
XZ426
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GC67693
Saccharopine hydrochloride
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GC67682
(S,S)-GSK321
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GC67670
L-Cysteine S-sulfate sodium hydrate
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GC52478
Telmisartan Acyl-β-D-Glucuronide (hydrate)
A major metabolite of telmisartan
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GC52413
5-Aminosalicylic Acid-d7
An internal standard for the quantification of 5-aminosalicylic acid
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GC52368
DL-Sulforaphane Glutathione
A metabolite of sulforaphane
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GC52355
BimS BH3 (51-76) (human) (trifluoroacetate salt)
A Bim-derived peptide
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GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
A metabolite of certain phenols and glycosides