Home >> Signaling Pathways >> Proteases >> Tyrosinases


Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes which are synthesised in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis.

  1. Cat.No. 产品名称 Information
  2. GC25188 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
  3. GC68399 Isolindleyin
  4. GC67978 Paltimatrectinib
  5. GC65543 Tetrapeptide-30
  6. GC62788 3-(2,4-Dihydroxyphenyl)propanoic acid Hydroumbellic acid (2,4-Dihydroxyhydrocinnamic acid) is used as pharmaceutical intermediates.
  7. GC61717 3-O-Ethyl-L-ascorbic acid A tyrosinase inhibitor
  8. GC48948 α-Ketoglutaric Acid (sodium salt) An intermediate in the citric acid cycle
  9. GC60493 3',4'-Dihydroxyacetophenone
  10. GC60206 Isoastilbin
  11. GC39327 3,4-Dimethoxyphenol
  12. GC46234 Tropolone A terpene with diverse biological activities
  13. GC38818 Mirificin
  14. GC38815 Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
  15. GC38720 (R)-Trolox
  16. GC38166 Trifolirhizin A flavonoid with anticancer and vasorelaxant activities
  17. GC45494 Lavendustin B An inhibitor of Glut1
  18. GC37707 Swertiajaponin
  19. GC36663 Mulberroside F
  20. GC36595 Methyl rosmarinate
  21. GC36402 Kushenol A
  22. GC36144 Glabrene
  23. GC35675 Chimonanthine
  24. GC35494 Benzoyloxypaeoniflorin
  25. GC45135 Validamycin A An inhibitor of trehalase
  26. GC40260 (±)-γ-Tocopherol A form of vitamin E
  27. GC40259 (±)-β-Tocopherol A lipid-soluble form of vitamin E
  28. GC33464 Oxyresveratrol (trans-Oxyresveratrol) A resveratrol analog
  29. GC31549 Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
  30. GC30564 2-Hydroxy-4-methoxybenzaldehyde A phenol with diverse biological activities
  31. GC30513 4-Butylresorcinol (Butylresorcinol) 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
  32. GC30136 2-Ketoglutaric acid An intermediate in the citric acid cycle
  33. GC19387 XMD8-87 A selective TNK2 inhibitor
  34. GC19385 XMD16-5 A TNK2 inhibitor
  35. GC13621 Hexylresorcinol An alkylresorcinol
  36. GC16079 Deoxyarbutin A tyrosinase inhibitor
  37. GN10304 Taxifolin A flavonol with antioxidant activity
  38. GN10073 Arbutin A glycosylated hydroquinone with diverse biological activities
  39. GN10055 Mulberroside A A phenol with diverse biological activities

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