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Tyrosinases(酪氨酸酶)

Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes which are synthesised in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis.

  1. Cat.No. 产品名称 Information
  2. GC70185 β-Sitostenone β-Sitostenone 是一种从 Cochlospermum vitifolium 中分离得到的甾醇。β-Sitostenone 可抑制酪氨酸酶 (tyrosinase) 活性,并具有抗黑色素生成和抗肿瘤活性。
  3. GC70079 Tyrosinase-IN-2 Tyrosinase-IN-2 (compound 67) 是一种有效的 tyrosinase 抑制剂。酪氨酸酶是一种含铜金属酶,负责黑色素生物合成和酶促褐变中的限速催化步骤。Tyrosinase-IN-2 具有研究皮肤美白剂和食品防腐剂的潜力。
  4. GC69583 Norartocarpetin Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性,其抑制活性 IC50 值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性,其 IC50 值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
  5. GC69115 Flanvotumab Flanvotumab (IMC-20D7S) 是一种靶向酪氨酸酶相关蛋白 (TYRP1) 的人源单克隆抗体,TYRP1 特异性表达于黑色素细胞和黑色素瘤细胞。Flanvotumab 通过自然杀伤介导的、抗体依赖的细胞介导的细胞毒作用 (ADCC) 而行使功能。Flanvotumab 具有较强的抗肿瘤活性和良好的耐受性。
  6. GC69028 D-Tyrosine-d4 D-Tyrosine-d4 是 D-Tyrosine 氘代物。D-Tyrosine 是酪氨酸的 D-型异构体。D-Tyrosine 通过抑制酪氨酸酶 (tyrosinase) 活性来负调节黑色素的合成。D-Tyrosine 抑制生物膜的形成并触发生物膜的自扩散,而不会抑制细菌的生长。
  7. GC68578 7-Methoxy obtusifolin 7-Methoxy obtusifolin (Compound 4) 是一种竞争性 tyrosinase 抑制剂,IC50 为 7.0 μM。
  8. GC25188 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
  9. GC68399 Isolindleyin Isolindleyin 是一种丁酰苯,是酪氨酸酶抑制剂,对人酪氨酸酶的 Kd 值为 54.8 μM。Isolindleyin 具有抗炎和抗黑色素生成活性,可用于缓解疼痛的研究。
  10. GC67978 Paltimatrectinib Paltimatrectinib (compound I-147) 是一种有效的酪氨酸激酶 (tyrosine kinase) 抑制剂,对肌球蛋白相关激酶 A (TrkA) 的 IC50 为 <10 nM。Paltimatrectinib 具有用于癌症和炎症性疾病的潜力。
  11. GC65543 Tetrapeptide-30 Tetrapeptide-30 是一种由四个氨基酸组成的亮肤肽,可充当酪氨酸酶抑制剂,通过减少酪氨酸酶的数量以及抑制黑色素细胞激活而淡化色素沉着,均匀肤色。
  12. GC62788 3-(2,4-Dihydroxyphenyl)propanoic acid Hydroumbellic acid (2,4-Dihydroxyhydrocinnamic acid) is used as pharmaceutical intermediates.
  13. GC61717 3-O-Ethyl-L-ascorbic acid A tyrosinase inhibitor
  14. GC48948 α-Ketoglutaric Acid (sodium salt) An intermediate in the citric acid cycle
  15. GC60493 3',4'-Dihydroxyacetophenone 3',4'-Dihydroxyacetophenone(3,4-DHAP)可从PiceaSchrenkiana中分离得到,能抑制酪氨酸酶,其IC50值为10μM。3',4'-Dihydroxyacetophenone(3,4-DHAP)是一种血管活性物质和抗氧化剂。
  16. GC60206 Isoastilbin Isoastilbin,RhizomaSmilacisglabrae和Astragalusmembranaceus中的一种二氢黄酮醇糖苷化合物。Isoastilbin抑制葡萄糖基转移酶(GTase)的IC50值为54.3μg/mL,还抑制酪氨酸酶(tyrosinase)活性。Isoastilbin具有神经保护,抗氧化,抗微生物和抗凋亡的特性,并可用于阿尔茨海默氏病的研究。
  17. GC39327 3,4-Dimethoxyphenol 3,4-Dimethoxyphenol 是植物来源的苯基丙烷化合物,可在化妆品中用作增白剂。3,4-Dimethoxyphenol 具有酪氨酸酶 (tyrosinase) 抑制活性。从细菌发酵液中分离出的 3,4-Dimethoxyphenol 具有有效的抗氧化作用。
  18. GC46234 Tropolone A terpene with diverse biological activities
  19. GC38818 Mirificin Mirificin (Puerarin apioside) 是葛根中的异黄酮。Mirificin 抑制酪氨酸酶 (TYR),IC50 为 12.66 μM。
  20. GC38815 Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
  21. GC38720 (R)-Trolox (R)-Trolox 是水溶性维生素 E 类似物,是一种竞争性酪氨酸酶抑制剂,Ki 值为 0.83 mM,ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。
  22. GC38166 Trifolirhizin A flavonoid with anticancer and vasorelaxant activities
  23. GC45494 Lavendustin B An inhibitor of Glut1
  24. GC37707 Swertiajaponin Swertiajaponin 是一种酪氨酸酶抑制剂,与酪氨酸酶结合囊形成多个氢键和疏水相互作用,IC50 值为 43.47 μM。Swertiajaponin 还能通过抑制氧化应激介导的 MAPK/MITF 信号导致酪氨酸酶蛋白水平下降。Swertiajaponin 能抑制黑色素积累,具有较强的抗氧化活性。
  25. GC36663 Mulberroside F Mulberroside F 是桑树 (Morus alba L.) 中的主要生物活性成分之一。Mulberroside F 抑制酪氨酸酶 (tyrosinase) 活性和黑色素形成。Mulberroside F 还具有超氧化物清除活性。
  26. GC36595 Methyl rosmarinate Methyl rosmarinate 是一种从 Rabdosia serra 中分离得到的非竞争性 tyrosinase 抑制剂,对蘑菇酪氨酸酶作用的 IC50 值为 0.28 mM,也能抑制 a-glucosidase[1]。
  27. GC36402 Kushenol A Kushenol A 是从苦参 (Sophora flavescent) 的根中分离出来的,一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂,IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种黄酮类抗氧化剂,对 α-葡萄糖苷酶 (alpha-glucosidase) 和 β-淀粉酶(beta-amylase)具有抑制作用。Kushenol A 被证实是可用于化妆品的针对皮肤美白和衰老的潜在物质。
  28. GC36144 Glabrene Glabrene 是一种来源于甘草根的异黄酮,具有雌激素样活性。Glabrene 是 tyrosinase 抑制剂,IC50 值为 3.5 μM。
  29. GC35675 Chimonanthine Chimonanthine 是腊梅中的生物碱,抑制酪氨酸酶及酪氨酸酶相关蛋白 1 mRNA 的表达,抑制黑色素的形成。
  30. GC35494 Benzoyloxypaeoniflorin Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根,是 tyrosinase 抑制剂,对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂,Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。
  31. GC45135 Validamycin A An inhibitor of trehalase
  32. GC40260 (±)-γ-Tocopherol A form of vitamin E
  33. GC40259 (±)-β-Tocopherol A lipid-soluble form of vitamin E
  34. GC33464 Oxyresveratrol (trans-Oxyresveratrol) A resveratrol analog
  35. GC31549 Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
  36. GC30564 2-Hydroxy-4-methoxybenzaldehyde A phenol with diverse biological activities
  37. GC30513 4-Butylresorcinol (Butylresorcinol) 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
  38. GC30136 2-Ketoglutaric acid An intermediate in the citric acid cycle
  39. GC19387 XMD8-87 A selective TNK2 inhibitor
  40. GC19385 XMD16-5 A TNK2 inhibitor
  41. GC13621 Hexylresorcinol An alkylresorcinol
  42. GC16079 Deoxyarbutin A tyrosinase inhibitor
  43. GN10304 Taxifolin

    A flavonol with antioxidant activity

  44. GN10073 Arbutin A glycosylated hydroquinone with diverse biological activities
  45. GN10055 Mulberroside A A phenol with diverse biological activities

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