PI3K/Akt/mTOR Signaling
- Akt(106)
- AMPK(65)
- CK2(8)
- DNA-PK(25)
- GSK-3(55)
- MELK(5)
- mTOR(98)
- PI3K(194)
- PI4K(13)
- PDK-1(12)
- PIKfyve(2)
- PKB(1)
- S6 Kinase(9)
- Cat.No. Product Name Information
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GC17330
(+)-Usniacin
Naturally occurring dibenzofuran derivative
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GC63524
(32-Carbonyl)-RMC-5552
(32-Carbonyl)-RMC-5552 是一种有效的 mTOR 抑制剂。(32-Carbonyl)-RMC-5552 抑制 mTORC1 和 mTORC2 底物 (p-P70S6K-(T389)、p-4E-BP1-(T37/36) 和 p-AKT1/2/3-(S473)) 磷酸化 pIC50s 分别为 > 9, >9, 以及 8-9 之间 (专利 WO2019212990A1, example 2)。
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GC62122
(E)-Akt inhibitor-IV
(E)-Akt inhibitor-IV ((E)-AKTIV) 是一种 PI3K-Akt 抑制剂,具有显著的细胞毒性。
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GC62736
(E/Z)-GSK-3β inhibitor 1
(E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂,可用于糖尿病的研究,其对 GSK-3β 的 IC50 值为 4.9 nM。
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GC34444
(R)-Nedisertib
(R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体,对DNA-PK的IC50值为7-30nM。
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GC63802
(R)-PS210
(R)-PS210 是 PS210 的 R 对映异构体 (化合物 4h-eutomer),是 PDK1 的底物选择性变构激活剂,AC50 值为 1.8 μM。(R)-PS210 靶向 PDK1 的 PIF 结合口袋。PIF: 蛋白激酶 C 相关激酶 2 (PRK2) 相互作用片段。
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GC62450
(S)-PI3Kα-IN-4
(S)-PI3Kα-IN-4 是一种有效的 PI3Kα 抑制剂,IC50 为 2.3 nM。(S)-PI3Kα-IN-4 对 PI3Kα 的选择性分别比 PI3Kβ,PI3Kδ 和 PI3Kγ 高38.3,4.25 和 4.93 倍。(S)-PI3Kα-IN-4 可用于癌症的研究。
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GC35037
1,3-Dicaffeoylquinic acid
1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物,具有抗氧化活性和自由基清除活性。
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GC13907
1-Azakenpaullone
GSK-3β inhibitor,potent and selective,cell-permeable
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GC41992
1-Deoxynojirimycin (hydrochloride)
1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II.
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GC42018
1-O-Octadecyl-2-O-methyl-sn-glycerol
1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA).
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GC13006
10-DEBC hydrochloride
Akt inhibitor
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GC41979
17β-hydroxy Wortmannin
17β-hydroxy Wortmannin is an analog of wortmannin.
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GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.
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GC46531
2-Amino-5-bromo-6-chloropyrazine
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GC35124
3α-Hydroxymogrol
3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物,为有效的 AMPK 激活剂,可增强 AMPK 的磷酸化水平。
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GC42237
3,5-dimethyl PIT-1
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN.
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GC13992
3-Guanidinopropionic Acid
AMPK stimulator
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GC10710
3-Methyladenine
3-Methyladenine is a classic autophagic agonist and inhibitor.
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GC32767
3BDO
3BDO是一种新型mTOR激活剂,也能抑制自噬。
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GC12078
3CAI
AKT inhibitor
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GC16960
4,5,6,7-Tetrabromobenzimidazole
CK2 inhibitor
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GC35162
5-Iodo-indirubin-3'-monoxime
5-Iodo-indirubin-3'-monoxime 是一种有效的 GSK-3β,CDK5/P25 和 CDK1/cyclin B 抑制剂,与 ATP 竞争性地结合酶的催化位点,IC50 值分别为 9,20 和 25 nM。
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GN10093
6-gingerol
Extracted from Zingiber officinale Roscoe;Suitability:Methanol,ethanol,DMSO;Store the product in sealed,cool and dry condition
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GC46724
6-Hydroxypyridin-3-ylboronic Acid
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GC46738
7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
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GC31348
7-Methoxyisoflavone
7-Methoxyisoflavone是异黄酮衍生物,也是腺苷一磷酸激活的蛋白激酶(AMPK)的激活剂。
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GC16157
740 Y-P
PI 3-kinase activator,cell permeable
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GC39152
9-ING-41
9-ING-41 是一个有效的糖原合酶激酶 3 (GSK-3) 抑制剂。9-ING-41 通过靶向中心体和微管结合的 GSK-3β 诱导前期凋亡和细胞周期停滞。9-ING-41 具有抗肿瘤活性。
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GC10336
A 1070722
GSK-3 inhibitor
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GC12502
A-443654
Akt inhibitor,potent and selective
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GC11875
A-674563
Akt1/PKA/CDK2 inhibitor,potent and selective
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GC35212
A-674563 hydrochloride
A-674563 hydrochloride 是具有选择性的高效 Akt1 抑制剂,其 Ki 值为 11 nM。
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GC11234
A-769662
AMPK activator,potent and reversible
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GC17550
A66
P110α inhibitor
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GC10860
Acalisib (GS-9820)
PI3Kδ inhibitor
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GC35242
Actein
Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖,诱导自噬和凋亡。Actein 在体内几乎没有毒性。
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GC16475
Afuresertib
pan-AKT inhibitor
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GC42747
Afuresertib (hydrochloride)
Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.
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GC10518
AICAR
AMPK activator
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GC10580
AICAR phosphate
AMPK activator
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GC42759
Akt Inhibitor IV
Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner.
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GC11589
AKT inhibitor VIII
Allosteric Akt kinase inhibitor
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GC16366
AKT Kinase Inhibitor
AKT Kinase Inhibitor
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GC33308
AKT-IN-1
AKT-IN-1是一种变构AKT抑制剂,IC50为1.042μM。
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GC35275
AKT-IN-3
AKT-IN-3 (compound E22) 是一种有效、口服的低 hERG 阻断 Akt 抑制剂,对 Akt1、Akt2 和 Akt3 作用的 IC50 值分别为 1.4 nM、1.2 nM 和 1.7 nM。AKT-IN-3 (compound E22) 对其他 AGC 家族激酶也有较好的抑制活性,如 PKA、PKC、ROCK1、RSK1、P70S6K、SGK。AKT-IN-3 (compound E22) 能诱导癌细胞凋亡,抑制癌细胞的转移。
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GC62190
AKT-IN-6
AKT-IN-6 (Example 13) 是一种有效的 AKT 抑制剂。AKT-IN-6抑制 Akt1、Akt2 和 Akt3, IC50s 分别 < 500nM,来自专利WO201305615A1。
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GC32939
Akt1 and Akt2-IN-1
Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。
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GC15841
Alsterpaullone
CDKs and GSK3β inhibitor
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GC42776
Amarogentin
A secoiridoid glycoside with diverse biological activities