PI3K/Akt/mTOR Signaling - Signaling Pathways

Cat.No. Product Name Information

GC17330 (+)-Usniacin Naturally occurring dibenzofuran derivative

GC63524 (32-Carbonyl)-RMC-5552 (32-Carbonyl)-RMC-5552 是一种有效的 mTOR 抑制剂。(32-Carbonyl)-RMC-5552 抑制 mTORC1 和 mTORC2 底物 (p-P70S6K-(T389)、p-4E-BP1-(T37/36) 和 p-AKT1/2/3-(S473)) 磷酸化 pIC50s 分别为 > 9, >9, 以及 8-9 之间 (专利 WO2019212990A1, example 2)。

GC62122 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV ((E)-AKTIV) 是一种 PI3K-Akt 抑制剂，具有显著的细胞毒性。

GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂，可用于糖尿病的研究，其对 GSK-3β 的 IC50 值为 4.9 nM。

GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。

GC63802 (R)-PS210 (R)-PS210 是 PS210 的 R 对映异构体 (化合物 4h-eutomer)，是 PDK1 的底物选择性变构激活剂，AC50 值为 1.8 μM。(R)-PS210 靶向 PDK1 的 PIF 结合口袋。PIF: 蛋白激酶 C 相关激酶 2 (PRK2) 相互作用片段。

GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 是一种有效的 PI3Kα 抑制剂，IC50 为 2.3 nM。(S)-PI3Kα-IN-4 对 PI3Kα 的选择性分别比 PI3Kβ，PI3Kδ 和 PI3Kγ 高38.3，4.25 和 4.93 倍。(S)-PI3Kα-IN-4 可用于癌症的研究。

GC35037 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。

GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable

GC41992 1-Deoxynojirimycin (hydrochloride) 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II.

GC42018 1-O-Octadecyl-2-O-methyl-sn-glycerol 1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA).

GC13006 10-DEBC hydrochloride Akt inhibitor

GC41979 17β-hydroxy Wortmannin 17β-hydroxy Wortmannin is an analog of wortmannin.

GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.

GC46531 2-Amino-5-bromo-6-chloropyrazine

GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物，为有效的 AMPK 激活剂，可增强 AMPK 的磷酸化水平。

GC42237 3,5-dimethyl PIT-1 PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN.

GC13992 3-Guanidinopropionic Acid AMPK stimulator

GC10710 3-Methyladenine

3-Methyladenine is a classic autophagic agonist and inhibitor.

GC32767 3BDO 3BDO是一种新型mTOR激活剂，也能抑制自噬。

GC12078 3CAI AKT inhibitor

GC16960 4,5,6,7-Tetrabromobenzimidazole CK2 inhibitor

GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime 是一种有效的 GSK-3β，CDK5/P25 和 CDK1/cyclin B 抑制剂，与 ATP 竞争性地结合酶的催化位点，IC50 值分别为 9，20 和 25 nM。

GN10093 6-gingerol Extracted from Zingiber officinale Roscoe;Suitability:Methanol,ethanol,DMSO;Store the product in sealed,cool and dry condition

GC46724 6-Hydroxypyridin-3-ylboronic Acid

GC46738 7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

GC31348 7-Methoxyisoflavone 7-Methoxyisoflavone是异黄酮衍生物，也是腺苷一磷酸激活的蛋白激酶(AMPK)的激活剂。

GC16157 740 Y-P PI 3-kinase activator,cell permeable

GC39152 9-ING-41 9-ING-41 是一个有效的糖原合酶激酶 3 (GSK-3) 抑制剂。9-ING-41 通过靶向中心体和微管结合的 GSK-3β 诱导前期凋亡和细胞周期停滞。9-ING-41 具有抗肿瘤活性。

GC10336 A 1070722 GSK-3 inhibitor

GC12502 A-443654 Akt inhibitor,potent and selective

GC11875 A-674563

Akt1/PKA/CDK2 inhibitor,potent and selective

GC35212 A-674563 hydrochloride A-674563 hydrochloride 是具有选择性的高效 Akt1 抑制剂，其 Ki 值为 11 nM。

GC11234 A-769662 AMPK activator,potent and reversible

GC17550 A66 P110α inhibitor

GC10860 Acalisib (GS-9820) PI3Kδ inhibitor

GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

GC16475 Afuresertib pan-AKT inhibitor

GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.

GC10518 AICAR AMPK activator

GC10580 AICAR phosphate AMPK activator

GC42759 Akt Inhibitor IV Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner.

GC11589 AKT inhibitor VIII Allosteric Akt kinase inhibitor

GC16366 AKT Kinase Inhibitor AKT Kinase Inhibitor

GC33308 AKT-IN-1 AKT-IN-1是一种变构AKT抑制剂，IC50为1.042μM。

GC35275 AKT-IN-3 AKT-IN-3 (compound E22) 是一种有效、口服的低 hERG 阻断 Akt 抑制剂，对 Akt1、Akt2 和 Akt3 作用的 IC50 值分别为 1.4 nM、1.2 nM 和 1.7 nM。AKT-IN-3 (compound E22) 对其他 AGC 家族激酶也有较好的抑制活性，如 PKA、PKC、ROCK1、RSK1、P70S6K、SGK。AKT-IN-3 (compound E22) 能诱导癌细胞凋亡，抑制癌细胞的转移。

GC62190 AKT-IN-6 AKT-IN-6 (Example 13) 是一种有效的 AKT 抑制剂。AKT-IN-6抑制 Akt1、Akt2 和 Akt3， IC50s 分别 < 500nM，来自专利WO201305615A1。

GC32939 Akt1 and Akt2-IN-1 Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。

GC15841 Alsterpaullone CDKs and GSK3β inhibitor

GC42776 Amarogentin A secoiridoid glycoside with diverse biological activities