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DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC19566 N-Nitrosodiethylamine
  3. GC38000 β-Boswellic acid β-Boswellic acid 是从乳香 Boswellia serrate 的树胶脂中分离出来的。β-Boswellic acid 是 5-脂氧合酶 (5-LO) 产物形成的非还原型抑制剂,其直接与 5-LO 相互作用或阻断其易位。β-Boswellic acid 抑制人白血病 HL-60 细胞中 DNA,RNA和蛋白质的合成。
  4. GC31365 γ-Oryzanol γ-Oryzanol有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs)。抑制DNMT1和DNMT3a,IC50分别为3.2μM和22.3μM。
  5. GC38194 (±)-10-Hydroxycamptothecin (±)-10-Hydroxycamptothecin 是从喜树中分到的生物碱,能够抑制拓扑异构酶 I (topoisomerase I) 的活性,具有广谱的抗肿瘤活性。
  6. GC33107 (±)-BAY-1251152 (±)-BAY-1251152是BAY-1251152的消旋混合物。BAY-1251152是一种有效且高选择性的PTEF/CDK9抑制剂。
  7. GC10867 (+)-Aphidicolin Tetracyclic diterpene antibiotic
  8. GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI1 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  9. GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  10. GC32429 (-)-BAY-1251152 (-)-BAY-1251152是BAY-1251152的一个对映体,旋光性为(-)。BAY-1251152是一种有效且高选择性的细胞周期依赖型蛋白激酶(PTEF/CDK9)的抑制剂。
  11. GC48635 (-)-Cryptopleurine
  12. GC40076 (-)-Voacangarine (-)-Voacangarine is an indole alkaloid originally isolated from V.
  13. GC38377 (2S,3R)-Voruciclib hydrochloride (2S,3R)-Voruciclib hydrochloride 是 Voruciclib hydrochloride 的低活性异构体。Voruciclib hydrochloride 是一种 CDK9 抑制剂。
  14. GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
  15. GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
  16. GC62735 (E/Z)-GO289 (E/Z)-GO289 是一种有效且选择性的酪蛋白激酶 2 (CK2) 抑制剂 (IC50=7 nM)。(E/Z)-GO289 强烈延长昼夜节律周期。(E/Z)-GO289 表现出与细胞时钟功能相关的对癌细胞生长的细胞类型依赖性抑制。
  17. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride 是一种有效的 CDK2,JAK2 和 FLT3 抑制剂,用于癌症研究。
  18. GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.
  19. GC39281 (R)-CR8 trihydrochloride (R)-CR8 trihydrochloride (CR8 trihydrochloride) 是 Roscovitine 的第二代类似物,是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 trihydrochloride 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1 μM)、CDK9/cyclin T (0.18 μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 trihydrochloride 诱导细胞凋亡并具有神经保护作用。
  20. GC64210 (R)-GSK-3685032 (R)-GSK-3685032 是 GSK-3685032 的 R 型异构体。GSK-3685032 是一种非时间依赖性、非共价、可逆的 DNMT1 选择性抑制剂,IC50=0.036 μM。GSK-3685032 诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。
  21. GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体,对DNA-PK的IC50值为7-30nM。
  22. GC41633 (R)-Prunasin (R)-Prunasin is a cyanogenic glucoside that is the precursor to amygdalin, a bitter component found in species of the genera Prunus and Olinia.
  23. GC34124 (rel)-MC180295 (rel)-MC180295是一种有效、选择性的CDK9-CyclinT1抑制剂,IC50值为5nM,对其选择性至少是对其他CDK激酶22倍。(rel)-MC180295同时抑制GSK-3α和GSK-3β。(rel)-MC180295具有的抗肿瘤活性。
  24. GC10098 (S)-10-Hydroxycamptothecin inhibitor of topoisomerase I
  25. GC34999 (S)-Ceralasertib (S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。
  26. GC13136 (S)-Crizotinib Potent MTH1 inhibitor
  27. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-DuocarmycinSA是一种DNA烷化剂(DNAalkylator),可作为抗体药物偶联物的毒素部分(ADCcytotoxin)起作用。
  28. GC39842 (Z)-4EGI-1 (Z)-4EGI-1 是 4EGI-1 的 Z-型异构体,是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ,IC50 为 43.5 μM,Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。
  29. GC19528 1,4-Benzoquinone
  30. GC41859 1,5,7-Triazabicyclo[4.4.0]dec-5-ene 1,5,7-Triazabicyclo[4.4.0]dec-5-ene is a bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations, including Michael additions, Wittig reactions, Henry reactions, and transesterification reactions.
  31. GC40468 1,5-Isoquinolinediol

    The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.

  32. GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent
  33. GC48909 1-Hydroxyanthraquinone
  34. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid (Compound 2) 是一种有效的,选择性的 HDAC8 抑制剂,IC50 为 14 μM。1-Naphthohydroxamic acid 对 HDAC8 的选择性高于 I 类 HDAC1 和 II 类 HDAC6 (IC50 >100 μM)。1-Naphthohydroxamic acid 不会增加整体组蛋白 H4 的乙酰化,也不会降低总细胞内 HDAC 的活性。1-Naphthohydroxamic acid 可诱导微管蛋白乙酰化。
  35. GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade) A formyl donor and cofactor
  36. GC63796 116-9e 116-9e (MAL2-11B) 是一种 Hsp70 共伴侣 DNAJA1 抑制剂。116-9e 抑制猿猴病毒40 (SV40) 的复制和 DNA 合成。116-9e 抑制肿瘤抗原 (TAg) 内源性 ATP 酶活性和 TAg 介导的 Hsp70 激活。
  37. GC49759 13C17-Mycophenolic Acid An internal standard for the quantification of mycophenolic acid
  38. GC46474 18-Deoxyherboxidiene
  39. GC61667 2′-Deoxy-2′-fluoroadenosine 2′-Deoxy-2′-fluoroadenosine可用于合成可与RNA杂交的2'-脱氧-2'-氟修饰的寡核苷酸。2′-Deoxy-2′-fluoroadenosine能被大肠杆菌嘌呤核苷磷酸化酶(PNP)有效地裂解成毒性物2-氟腺嘌呤(FAde)。2′-Deoxy-2′-fluoroadenosine对表达大肠杆菌PNP的肿瘤表现出良好的体内活性。
  40. GC62530 2’-O-Me-C(Bz) Phosphoramidite 2’-O-Me-C(Bz) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。
  41. GC62529 2’-OMe-A(Bz) Phosphoramidite 2’-OMe-A(Bz) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。
  42. GC62531 2’-OMe-G(ibu) Phosphoramidite 2’-OMe-G(ibu) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。
  43. GC46508 2',2'-Difluoro-2'-deoxyuridine
  44. GC42061 2',3'-Dideoxyadenosine 5'-triphosphate 2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).
  45. GC46519 2',3'-O-Isopropylideneguanosine
  46. GC46540 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)
  47. GC48440 2'-Deoxycytidine-5'-triphosphate (sodium salt)
  48. GC42151 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) 2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis.
  49. GC33430 2'-Deoxypseudoisocytidine 2'-Deoxypseudoisocytidine是一个核苷类似物。
  50. GC35072 2'-O,4'-C-Methyleneuridine 2’-O,4’-C-Methyleneuridine (Compound 15a) 是一种双环核苷。
  51. GC42080 2'2'-cGAMP (sodium salt) 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds.

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