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ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

  1. Cat.No. 产品名称 Information
  2. GC69053 Elimusertib-d3 Elimusertib-d3 (BAY 1895344-d3) 是 Elimusertib-d3 (BAY 1895344-d3) 的氘代物。Elimusertib 是一种有效、可口服、选择性的 ATR 抑制剂,具有抗肿瘤活性。
  3. GC68707 ATR-IN-4 ATR-IN-4 是一种有效的 ATR 抑制剂。ATR-IN-4 抑制人前列腺癌细胞 DU145 和人肺癌细胞 NCI-H460 的生长,IC50 分别为 130.9 nM 和 41.33 nM。(摘自专利 CN112142744A,化合物13)。
  4. GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
  5. GC65514 ATR inhibitor 1 ATR inhibitor 1 是一种 ATR 抑制剂,Ki 值低于 1 µμ,详细信息请参考专利 WO2015187451A1,化合物 I-l。
  6. GC65327 ATM Inhibitor-5 M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
  7. GC64938 AZD-7648 An inhibitor of DNA-PK
  8. GC64539 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
  9. GC64278 RP-3500 RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
  10. GC62108 Elimusertib hydrochloride Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM,具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
  11. GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
  12. GC34999 (S)-Ceralasertib (S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。
  13. GC34374 BAY-1895344 hydrochloride An ATR inhibitor
  14. GC33420 BAY-1895344 An ATR inhibitor
  15. GC33404 KU 59403

    KU59403是ATM的一个有效抑制剂,其IC50值为3nM。

  16. GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂,在细胞中的 IC50 为 0.78 nM。
  17. GC19047 AZ32 An ATM kinase inhibitor
  18. GC11593 AZD0156 An ATM kinase inhibitor
  19. GC16941 AZD6738 An ATR kinase inhibitor
  20. GC15337 VE-822 ATR抑制剂
  21. GC10196 ETP-46464 An ATR inhibitor
  22. GC16489 CP-466722 An ATM kinase inhibitor
  23. GC14526 CGK733 An anticancer compound
  24. GC12054 KU-60019 A potent ATM kinase inhibitor
  25. GC10293 VE-821

    An inhibitor of ATR

  26. GC11118 KU 55933 An ATM kinase inhibitor
  27. GC14949 AZ20 A potent, selective ATR inhibitor
  28. GN10696 Garcinone C Garcinone C 是一种黄酮衍生物,是一种从 Garcinia oblongifolia Champ 中提取的天然化合物,用作抗炎、收敛和促进肉芽的药物,对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平,同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。

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