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Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. 产品名称 Information
  2. GC26065 WAY-354831 WAY-354831 exhibits antibacterial activity.
  3. GC26055 WAY-301398 WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).
  4. GC26000 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
  5. GC25669 Nilotinib hydrochloride Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
  6. GC25662 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
  7. GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
  8. GC68339 Ponsegromab
  9. GC68333 Disitertide diammonium
  10. GC67686 PKCiota-IN-2 formic
  11. GC66338 ROCK1-IN-1 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
  12. GC66050 Rho-Kinase-IN-2
  13. GC66006 Protein kinase inhibitor H-7
  14. GC65592 SNIPER(ABL)-020
  15. GC65585 Mongersen
  16. GC65539 Fresolimumab
  17. GC65329 EW-7195
  18. GC65294 ALK2-IN-2
  19. GC65126 PKC-iota inhibitor 1
  20. GC64815 Aurothiomalate sodium
  21. GC64462 Asciminib hydrochloride An allosteric inhibitor of Abl1
  22. GC64326 Hydrochlorothiazid-d2
  23. GC64263 Kobophenol A
  24. GC63829 A 83-01 sodium A TGF-β type I receptor inhibitor
  25. GC63778 Myelin Basic Protein TFA
  26. GC63716 Sovesudil hydrochloride
  27. GC63439 Sangivamycin
  28. GC63351 Sovesudil
  29. GC63333 Cotosudil
  30. GC63332 S116836
  31. GC63253 Verosudil
  32. GC63177 Ruboxistaurin Ruboxistaurin (LY333531) HCl is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.
  33. GC62868 BIO-013077-01
  34. GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
  35. GC49269 Myr-ZIP A PKMζ inhibitor
  36. GC62612 CC-90005
  37. GC62478 ζ-Stat ζ-Stat (NSC37044) is a specific and atypical protein kinase Cζ (PKCζ) inhibitor, with an IC50 of 5 μM.
  38. GC62453 GZD856 formic
  39. GC62207 Olverembatinib A Bcr/Abl inhibitor
  40. GC62146 XST-14
  41. GC62103 Vodobatinib Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.
  42. GC61852 PF-4618433
  43. GC61776 Ingenol 3,20-dibenzoate
  44. GC61585 Pep2m, myristoylated TFA
  45. GC50704 CRT 0066854 hydrochloride A PKCι and PKCζ inhibitor
  46. GC60930 Imatinib D4
  47. GC60782 Disitertide TFA
  48. GC60274 O-Desmethyl Midostaurin
  49. GC60210 Isosaponarin
  50. GC60037 A-3 hydrochloride A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  51. GC39612 Imatinib D8

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