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TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation
  3. GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration
  4. GC10603 (-)-epicatechin gallate major catechin in green tea
  5. GC17242 (-)-epigallocatechin green tea epicatechin
  6. GC14049 (-)-Epigallocatechin gallate (EGCG)

    抗氧化剂、抗血管生成剂和抗肿瘤剂

  7. GC14012 (-)-Indolactam V protein kinase C activator
  8. GC41737 (S)-Glycyl-H-1152 (hydrochloride) Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
  9. GC18062 1,2-Dilauroyl-sn-glycerol
  10. GC14134 1,2-Dimyristoyl-sn-glycerol
  11. GC13877 1,2-Dipalmitoyl-sn-glycerol

    weak activator of PKC

  12. GC12662 1,2-Distearoyl-sn-glycerol
  13. GC12172 1-Naphthyl PP1 Src family kinases inhibitor
  14. GC41863 10,11-dehydro Curvularin

    10,11-dehydro Curvularin is a natural mycotoxin that has cytotoxic activity against select cancer cell lines.

  15. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    一种佛波酯,是蛋白激酶 C (PKC) 和 SphK 的激活剂。

  16. GC13927 A 77-01 Potent ALK5 inhibitor
  17. GC10166 A 83-01 ALK-5 inhibitor
  18. GC35210 A 83-01 sodium salt A 83-01 sodium salt 是一种有效的 TGF-β I 型受体 ALK5,及 ALK4 和 ALK7 抑制剂,能够抑制 ALK5,ALK4 和 ALK7 诱导的转录,IC50 值分别为 12,45 和 7.5 nM。
  19. GC60037 A-3 hydrochloride A-3 hydrochloride 是靶向多种激酶 (kinase) 的强效、细胞渗透的、可逆的、ATP 竞争性的非选择性拮抗剂。A-3 hydrochloride 是针对 PKA (Ki=4.3 µM),酪蛋白激酶 II (Ki=5.1 µM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 µM) 的抑制剂。A-3 hydrochloride 还抑制 PKC 和酪蛋白激酶 I 的活性,Ki 分别为 47 µM 和 80 µM。
  20. GC15579 Adaphostin P210bcr/abl tyrosine kinase inhibitor
  21. GC16475 Afuresertib pan-AKT inhibitor

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