TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
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GC26065
WAY-354831
WAY-354831 exhibits antibacterial activity.
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GC26055
WAY-301398
WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).
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GC26000
TP0427736 HCl
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
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GC25669
Nilotinib hydrochloride
Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
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GC25662
N-Desmethyltamoxifen
N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
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GC25482
GSK269962A HCl
GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
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GC68339
Ponsegromab
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GC68333
Disitertide diammonium
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GC67686
PKCiota-IN-2 formic
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GC66338
ROCK1-IN-1
WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
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GC66050
Rho-Kinase-IN-2
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GC66006
Protein kinase inhibitor H-7
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GC65592
SNIPER(ABL)-020
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GC65585
Mongersen
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GC65539
Fresolimumab
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GC65329
EW-7195
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GC65294
ALK2-IN-2
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GC65126
PKC-iota inhibitor 1
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GC64815
Aurothiomalate sodium
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GC64462
Asciminib hydrochloride
An allosteric inhibitor of Abl1
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GC64326
Hydrochlorothiazid-d2
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GC64263
Kobophenol A
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GC63829
A 83-01 sodium
A TGF-β type I receptor inhibitor
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GC63778
Myelin Basic Protein TFA
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GC63716
Sovesudil hydrochloride
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GC63439
Sangivamycin
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GC63351
Sovesudil
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GC63333
Cotosudil
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GC63332
S116836
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GC63253
Verosudil
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GC63177
Ruboxistaurin
Ruboxistaurin (LY333531) HCl is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.
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GC62868
BIO-013077-01
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GC49334
Chroman 1 (hydrochloride hydrate)
A ROCK2 inhibitor
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GC49269
Myr-ZIP
A PKMζ inhibitor
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GC62612
CC-90005
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GC62478
ζ-Stat
ζ-Stat (NSC37044) is a specific and atypical protein kinase Cζ (PKCζ) inhibitor, with an IC50 of 5 μM.
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GC62453
GZD856 formic
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GC62207
Olverembatinib
A Bcr/Abl inhibitor
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GC62146
XST-14
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GC62103
Vodobatinib
Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.
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GC61852
PF-4618433
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GC61776
Ingenol 3,20-dibenzoate
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GC61585
Pep2m, myristoylated TFA
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GC50704
CRT 0066854 hydrochloride
A PKCι and PKCζ inhibitor
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GC60930
Imatinib D4
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GC60782
Disitertide TFA
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GC60274
O-Desmethyl Midostaurin
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GC60210
Isosaponarin
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GC60037
A-3 hydrochloride
A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
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GC39612
Imatinib D8