Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC62478 Ζ-Stat ζ-Stat (NSC37044) 是一种特异且非典型的 PKC-ζ 的抑制剂,IC50 值为 5 μM。ζ-Stat 可以减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外具有抗肿瘤活性。
  3. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation
  4. GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration
  5. GC10603 (-)-epicatechin gallate major catechin in green tea
  6. GC17242 (-)-epigallocatechin green tea epicatechin
  7. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  8. GC14012 (-)-Indolactam V A protein kinase C activator
  9. GC41737 (S)-Glycyl-H-1152 (hydrochloride) Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
  10. GC18062 1,2-Dilauroyl-sn-glycerol
  11. GC14134 1,2-Dimyristoyl-sn-glycerol
  12. GC13877 1,2-Dipalmitoyl-sn-glycerol

    weak activator of PKC

  13. GC12662 1,2-Distearoyl-sn-glycerol
  14. GC12172 1-Naphthyl PP1 Src family kinases inhibitor
  15. GC41863 10,11-dehydro Curvularin A natural mycotoxin
  16. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    An activator of ERK/MAPK

  17. GC13927 A 77-01 Potent ALK5 inhibitor
  18. GC10166 A 83-01 ALK-5 inhibitor
  19. GC63829 A 83-01 sodium A 83-01 sodium 是一种有效的 TGF-β I 型受体 ALK5,ALK4 和 ALK7 的抑制剂,能够抑制 ALK5,ALK4 和 ALK7 诱导的转录,IC50 值分别为 12 nM,45 nM 和 7.5 nM。
  20. GC35210 A 83-01 sodium salt A potent inhibitor of TGF-β type I receptor ALK5 kinase
  21. GC60037 A-3 hydrochloride A-3 hydrochloride 是靶向多种激酶 (kinase) 的强效、细胞渗透的、可逆的、ATP 竞争性的非选择性拮抗剂。A-3 hydrochloride 是针对 PKA (Ki=4.3 µM),酪蛋白激酶 II (Ki=5.1 µM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 µM) 的抑制剂。A-3 hydrochloride 还抑制 PKC 和酪蛋白激酶 I 的活性,Ki 分别为 47 µM 和 80 µM。
  22. GC15579 Adaphostin P210bcr/abl tyrosine kinase inhibitor
  23. GC16475 Afuresertib pan-AKT inhibitor
  24. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.
  25. GC11050 ALK5 Inhibitor II (hydrochloride) ALK5 inhibitor
  26. GC34300 AR-13324 analog mesylate AR-13324类似物甲磺酸盐是AR-13324的类似物。
  27. GC19034 AR-13324 mesylate AR-13324 is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.
  28. GC31959 AS2521780 AS2521780是新颖的PKCθ选择性抑制剂,IC50值为0.48nM。
  29. GC32703 Asciminib (ABL001) Asciminib(ABL001)是一种有效和选择性的变构Bcr-Abl抑制剂;抑制Ba/F3细胞生长的IC50值为0.25nM。
  30. GN10534 Asiaticoside Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
  31. GC10914 AST 487 RET kinase inhibitor
  32. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive
  33. GC10638 AT9283 Aurora kinase/JAK inhibitor
  34. GC50589 AZ 12799734 Potent TGF-βRI inhibitor
  35. GC35442 Azaindole 1 Azaindole 1是有口服活性,ATP-竞争型的 ROCK 抑制剂,对ROCK-1 和 ROCK-2 的 IC50 值分别为0.6 和 1.1 nM。
  36. GC35462 Bafetinib

    Bcr-Abl/Lyn tyrosine kinase inhibitor

  37. GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1是一种BCR-ABL酪氨酸激酶抑制剂,pIC50值为6.46,可能用于慢性髓细胞白血病的研究。
  38. GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2是BCR-ABL1激酶的抑制剂,其对ABL1native和ABL1T315I的IC50值分别为57nM,773nM。
  39. GC32868 BDP5290 BDP5290是ROCK和MRCK的有效抑制剂,对于ROCK1,ROCK2,MRCKα和MRCKβ的IC50值分别为5nM,50nM,10nM和100nM。
  40. GC34493 BIBF0775 BIBF0775是有效,选择性的TGFβI型受体(Alk5)的抑制剂,IC50为34nM。
  41. GC62868 BIO-013077-01 BIO-013077-01 是一种吡唑类的 TGF-β 抑制剂。
  42. GC12135 Bisindolylmaleimide II protein kinase C (PKC) inhibitor
  43. GC14716 Bisindolylmaleimide IV protein kinase C (PKC) inhibitor
  44. GC17239 Bisindolylmaleimide V negative control for protein kinase C (PKC)-inhibitory activity
  45. GC13226 Bisindolylmaleimide VIII (acetate) A protein kinase C (PKC) inhibitor
  46. GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
  47. GC35530 BJE6-106 BJE6-106 (B106) 是一种有效的选择性 PKCδ 抑制剂,IC50 值为 0.05 μM,BJE6-106 (B106) 靶向 PKCδ 的选择性是 PKC 同工酶 PKCα 的 1000倍 (IC50=50 μM)。BJE6-106 (B106) 可以诱导 caspase 依耐性细胞凋亡 (apoptosis)。BJE6-106 (B106) 具有肿瘤特异性作用。
  48. GC50593 BMP signaling agonist sb4

    Potent BMP4 agonist

  49. GC13343 Bosutinib (SKI-606) A potent inhibitor of Src and Abl kinases
  50. GC40080 Bosutinib-d8 Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS.
  51. GC17670 Bryostatin 1 PKC activator

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