SMAD

SMAD are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream gene transcription.

Products for SMAD

Cat.No. 产品名称 Information
GC44903 SMAD3 Inhibitor, SIS3 An inhibitor of TGF-β signaling
GC41863 10,11-dehydro Curvularin
α,β-dehydro Curvularin
A natural mycotoxin
GC34060 Disitertide (P144)
地司特泰,P144
Disitertide (P144) (P144) 是一种肽类转化生长因子-β 1 (TGF-β1) 抑制剂，专门设计用于阻断与其受体的相互作用。 Disitertide (P144) (P144) 也是一种 PI3K 抑制剂和凋亡诱导剂。
GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo，TGF-β和Wnt信号通路的抑制剂，并拥有抗肿瘤活性。
GC32250 Chebulinic acid
诃子林鞣酸
An ellagitannin with diverse biological activities
GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide))
常山酮溴酸盐; RU-19110 hydrobromide
Halofuginone (RU-19110) hydrobromid 是一种Ferifugine 衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂，Ki 为 18.3 nM。
GC31650 Halofuginone (RU-19110)
常山酮; RU-19110
Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
GC19338 SRI-011381 hydrochloride A TGF-β signaling activator
GC17191 SIS3 HCl
SIS3 盐酸盐
SIS3 HCl是一种Smad3抑制剂，可抑制Smad3 的磷酸化， IC₅₀ 为3 μM。
GC15057 Kartogenin
2-([1,1-联苯]-4-基氨基甲酰)苯甲酸,KGN
A potent inducer of chondrocyte differentiation
GC12790 Pirfenidone
吡非尼酮; AMR69
吡非尼酮（Pirfenidone；AMR69）是一种具有口服活性的抗纤维化药物，可减弱纤维细胞中趋化因子CCL2和CCL12的产生。
GC11604 LY364947
HTS466284
Inhibitor of TGF-β type-1 receptors
GC17523 Hydrochlorothiazide
氢氯噻嗪; HCTZ
A thiazide diuretic
GC16580 LDN-193189
LDN 193189;LDN193189

An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
GC16793 RepSox
2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶,E-616452;SJN 2511;E616452;SJN2511;E 616452;SJN-2511,ALK5 Inhibitor II
A selective inhibitor of ALK5
GC14931 LDN193189 Hydrochloride
LDN 193189 hydrochloride; LDN-193189 hydrochloride
LDN193189 Hydrochloride是一种选择性转录活性形态发生蛋白（BMP）I型受体抑制剂，BMP受体家族包括激活素受体样激酶（ALK1、ALK2、ALK3和ALK6）。LDN193189 Hydrochloride抑制ALK2和ALK3的IC₅₀值分别为5nM和30nM。
GN10378 Oxymatrine
氧化苦参碱
A natural antiviral and anti-fibrosis alkaloid
GN10534 Asiaticoside
积雪草苷
A saponin with significant wound healing activity