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Hydrochlorothiazide

目录号 GC17523

diuretic drug of the thiazide class

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥410.00
现货
5000mg
¥410.00
现货
25000mg
¥620.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Hydrochlorothiazide is a diuretic drug of the thiazide class. Target: OthersHydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance [1].

References:
[1]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.

Chemical Properties

Cas No. 58-93-5 SDF
化学名 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Canonical SMILES C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
分子式 C7H8ClN3O4S2 分子量 297.74
溶解度 ≥ 10.7mg/mL in DMSO 储存条件 Store at -20°C,unstable in solution, ready to use.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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