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MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC48920 β-Carboline-1-carboxylic Acid
  3. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
  4. GC60393 (-)-Zuonin A (-)-ZuoninA(D-Epigalbacin)是一种天然木质素,是有效的、选择性的JNKs抑制剂,对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。
  5. GC13944 (5Z)-7-Oxozeaenol

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

  6. GC63903 (E)-Osmundacetone (E)-Osmundacetone 是 Osmundacetone 的异构体。Osmundacetone 可以显着抑制 MAPK 磷酸化,包括 JNK,ERK 和 p38 激酶,具有抗氧化应激的神经保护作用。
  7. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  8. GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
  9. GC12851 10Z-Hymenialdisine Pan kinase inhibitor
  10. GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate
  11. GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone 是从熟地黄中分离出的,可通过阻断 ERK1/2 和 NF-κB 信号通路来抑制活化巨噬细胞中炎症介质的产生。
  12. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物,来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK,JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性,包括抗菌,抗癌,抗逆转录酶,抗结核,抗疟,抗炎和抗氧化活性。
  13. GC48381 5'-pApA (sodium salt)
  14. GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone 是一种具有抗炎作用的 p38-α MAPK 抑制剂。5,6,7-Trimethoxyflavone,从几种植物中分离出,包括 Zeyhera tuberculosa, Callicarpa japonica,和 Kickxia lanigera。
  15. GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
  16. GC12834 6-Bnz-cAMP sodium salt cAMP analog,PKA activator
  17. GC42616 7-oxo Staurosporine

    7-oxo Staurosporine is an antibiotic originally isolated from S.

  18. GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA
  19. GC42622 8-bromo-Cyclic AMP 8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.
  20. GC15352 8-CPT-Cyclic AMP (sodium salt) lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG
  21. GC60037 A-3 hydrochloride A-3 hydrochloride 是靶向多种激酶 (kinase) 的强效、细胞渗透的、可逆的、ATP 竞争性的非选择性拮抗剂。A-3 hydrochloride 是针对 PKA (Ki=4.3 µM),酪蛋白激酶 II (Ki=5.1 µM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 µM) 的抑制剂。A-3 hydrochloride 还抑制 PKC 和酪蛋白激酶 I 的活性,Ki 分别为 47 µM 和 80 µM。
  22. GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Muramyl dipeptide (MDP) inhibits HIV replication in CD4? H9 lymphocytes..
  23. GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖,诱导自噬和凋亡。Actein 在体内几乎没有毒性。
  24. GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.
  25. GC32797 AD80 AD80是多种激酶的抑制剂,抑制RET,RAF,SRC和S6K活性,但对mTOR的活性明显减弱。
  26. GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase
  27. GC46808 ADTL-EI1712
  28. GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis
  29. GC17265 AG-126 ERK1 (p44) and ERK2 (p42) inhibitor
  30. GC12646 AL 8697 p38α inhibitor,potent and selective
  31. GC14899 AMG 548

    P38α inhibitor,potent and selective

  32. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride 是一种有效的,口服有效的,选择性 p38α 抑制剂 (Ki=0.5 nM),对 p38β 略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 >1000 倍的选择性。AMG-548 dihydrochloride 也有效抑制全血 LPS 刺激的 TNFα (IC50=3 nM)。AMG-548 dihydrochloride 通过直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε 来抑制 Wnt 信号传导。
  33. GC11559 Anisomycin

    JNK agonist, potent and specific

  34. GC15240 APS-2-79 KSR-dependent MAPK modulator
  35. GC32692 APTO-253 (LOR-253) APTO-253是一种Kruppel-likefactor4诱导剂,同时可稳定Gquadruplex结构,具有抗癌活性。
  36. GN10063 Arctigenin Anti-inflammatory, antiproliferative
  37. GC12882 AS 602801 Jun Kinase Inhibitor
  38. GC10010 AS601245 A c-Jun NH2-terminal protein kinase inhibitor
  39. GC19041 ASK1-IN-1 ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.
  40. GC62426 ASK1-IN-2 ASK1-IN-2 是一种有效的,具有口服活性的凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 值为 32.8 nM。ASK1-IN-2 可用于溃疡性结肠炎的研究。
  41. GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷,从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤,抗氧化和抗炎作用。Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (MAPK) 信号通路抑制炎性细胞因子(TNF-α,IL-6) 释放发挥抗炎作用。
  42. GN10494 Astragaloside IV

    Anti-inflammatory;extract of Astragali radix

  43. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive
  44. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

  45. GC10918 AT7867 dihydrochloride Akt1 and p70S6K/PKA inhibitor
  46. GC31667 AX-15836 AX-15836是有效,选择性的ERK5抑制剂,IC50值为8nM。
  47. GC15055 AZ 628 Raf kinases,potent and ATP-competitive
  48. GC19479 AZ304

    A dual inhibitor

  49. GC19048 AZD-0364 AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM.
  50. GC17030 AZD6244(Selumetinib) A MEK inhibitor
  51. GC31924 AZD7624 AZD7624是一种可吸入的p38抑制剂,具有高效的抗炎活性。

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