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MAPK Signaling(MAPK信号通路)

Products for  MAPK Signaling

  1. Cat.No. 产品名称 Information
  2. GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
  3. GC25521 IMM-H007 IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
  4. GC25420 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
  5. GC25289 CompK CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
  6. GC67964 Exarafenib
  7. GC67905 ERK1/2 inhibitor 7
  8. GC67800 B-Raf IN 11
  9. GC65978 B-Raf IN 10
  10. GC65949 GNE-9815 GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.
  11. GC65917 Andrograpanin
  12. GC65510 ERK1/2 inhibitor 1
  13. GC65479 PROTAC B-Raf degrader 1
  14. GC65329 EW-7195
  15. GC65303 Jaspamycin
  16. GC65298 DMX-5804 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
  17. GC65297 MW-150 An inhibitor of p38α MAPK
  18. GC64904 MAP855
  19. GC64828 PLX7922
  20. GC64634 MLK-IN-1
  21. GC64580 MMI-0100
  22. GC64550 B-Raf IN 2
  23. GC64496 EF24
  24. GC64460 8-Chloro-cAMP
  25. GC64292 MS432
  26. GC64287 SR15006
  27. GC64035 Hirsutenone
  28. GC63903 (E)-Osmundacetone
  29. GC49700 Takeda-6d A dual inhibitor of RAF kinases and VEGFR2
  30. GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib
  31. GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
  32. GC63680 MLKL-IN-2
  33. GC63569 HPK1-IN-4
  34. GC63554 PD0325901-O-C2-dioxolane
  35. GC63459 ERK-IN-3 benzenesulfonate
  36. GC63441 CC-99677
  37. GC63425 Zunsemetinib
  38. GC63317 HPK1-IN-8
  39. GC63264 Zapnometinib Zapnometinib (PD0184264, ATR-002), an major active metabolite of CI-1040, is a novel MEK inhibitor with an IC50 of 5.7 nM.
  40. GC63176 Rp-cAMPS sodium salt
  41. GC63144 PF-05381941
  42. GC63059 MAP4K4-IN-3 MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
  43. GC63006 HPK1-IN-7
  44. GC63000 Gypenoside L
  45. GC49440 ML-9 A PKB/Akt inhibitor
  46. GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase
  47. GC49265 PKI (14-22) amide (myristoylated) (trifluoroacetate salt) A PKA inhibitor
  48. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram
  49. GC49186 O-Demethyl Apremilast An active metabolite of apremilast
  50. GC49150 Tpl2 Kinase Inhibitor (hydrochloride) A Tpl2 inhibitor
  51. GC62675 SM1-71

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