MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

GC25521 IMM-H007 IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.

GC25420 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.

GC25289 CompK CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.

GC67964 Exarafenib

GC67905 ERK1/2 inhibitor 7

GC67800 B-Raf IN 11

GC65978 B-Raf IN 10

GC65949 GNE-9815 GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.

GC65917 Andrograpanin

GC65510 ERK1/2 inhibitor 1

GC65479 PROTAC B-Raf degrader 1

GC65329 EW-7195

GC65303 Jaspamycin

GC65298 DMX-5804 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

GC65297 MW-150 An inhibitor of p38α MAPK

GC64904 MAP855

GC64828 PLX7922

GC64634 MLK-IN-1

GC64580 MMI-0100

GC64550 B-Raf IN 2

GC64496 EF24

GC64460 8-Chloro-cAMP

GC64292 MS432

GC64287 SR15006

GC64035 Hirsutenone

GC63903 (E)-Osmundacetone

GC49700 Takeda-6d A dual inhibitor of RAF kinases and VEGFR2

GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib

GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.

GC63680 MLKL-IN-2

GC63569 HPK1-IN-4

GC63554 PD0325901-O-C2-dioxolane

GC63459 ERK-IN-3 benzenesulfonate

GC63441 CC-99677

GC63425 Zunsemetinib

GC63317 HPK1-IN-8

GC63264 Zapnometinib Zapnometinib (PD0184264, ATR-002), an major active metabolite of CI-1040, is a novel MEK inhibitor with an IC50 of 5.7 nM.

GC63176 Rp-cAMPS sodium salt

GC63144 PF-05381941

GC63059 MAP4K4-IN-3 MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.