MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling
- ERK(72)
- MEK1/2(56)
- NKCC(6)
- MNK(5)
- PKA(49)
- p38(89)
- Rac(2)
- Raf(62)
- RasGAP (Ras- P21)(1)
- JNK(54)
- cAMP(32)
- Protein Kinase G(2)
- RSK(28)
- Other(4)
- MAPKAPK(1)
- MKK(2)
- KLF(3)
- MAP3K(18)
- MAP4K(16)
- MAPKAPK2 (MK2)(9)
- Mixed Lineage Kinase(6)
- Cat.No. 产品名称 Information
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GC25982
Tanzisertib(CC-930)
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
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GC25521
IMM-H007
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
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GC25420
Fipexide hydrochloride
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
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GC25289
CompK
CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
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GC67964
Exarafenib
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GC67905
ERK1/2 inhibitor 7
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GC67800
B-Raf IN 11
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GC65978
B-Raf IN 10
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GC65949
GNE-9815
GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.
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GC65917
Andrograpanin
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GC65510
ERK1/2 inhibitor 1
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GC65479
PROTAC B-Raf degrader 1
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GC65329
EW-7195
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GC65303
Jaspamycin
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GC65298
DMX-5804
DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
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GC65297
MW-150
An inhibitor of p38α MAPK
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GC64904
MAP855
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GC64828
PLX7922
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GC64634
MLK-IN-1
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GC64580
MMI-0100
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GC64550
B-Raf IN 2
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GC64496
EF24
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GC64460
8-Chloro-cAMP
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GC64292
MS432
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GC64287
SR15006
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GC64035
Hirsutenone
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GC63903
(E)-Osmundacetone
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GC49700
Takeda-6d
A dual inhibitor of RAF kinases and VEGFR2
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GC49686
N-desmethyl Regorafenib N-oxide
An active metabolite of regorafenib
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GC63700
5,6,7-Trimethoxyflavone
5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
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GC63680
MLKL-IN-2
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GC63569
HPK1-IN-4
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GC63554
PD0325901-O-C2-dioxolane
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GC63459
ERK-IN-3 benzenesulfonate
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GC63441
CC-99677
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GC63425
Zunsemetinib
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GC63317
HPK1-IN-8
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GC63264
Zapnometinib
Zapnometinib (PD0184264, ATR-002), an major active metabolite of CI-1040, is a novel MEK inhibitor with an IC50 of 5.7 nM.
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GC63176
Rp-cAMPS sodium salt
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GC63144
PF-05381941
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GC63059
MAP4K4-IN-3
MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
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GC63006
HPK1-IN-7
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GC63000
Gypenoside L
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GC49440
ML-9
A PKB/Akt inhibitor
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GC49285
Adenosine 5’-methylenediphosphate (hydrate)
An inhibitor of ecto-5’-nucleotidase
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GC49265
PKI (14-22) amide (myristoylated) (trifluoroacetate salt)
A PKA inhibitor
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GC49241
Methyl Diethyldithiocarbamate
An active metabolite of disulfiram
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GC49186
O-Demethyl Apremilast
An active metabolite of apremilast
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GC49150
Tpl2 Kinase Inhibitor (hydrochloride)
A Tpl2 inhibitor
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GC62675
SM1-71