Raf - MAPK Signaling - Signaling Pathways

Cat.No. 产品名称 Information

GC68350 Tinlorafenib

GC67964 Exarafenib

GC67800 B-Raf IN 11

GC65978 B-Raf IN 10

GC65949 GNE-9815 GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.

GC65479 PROTAC B-Raf degrader 1

GC64828 PLX7922

GC64550 B-Raf IN 2

GC49700 Takeda-6d A dual inhibitor of RAF kinases and VEGFR2

GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib

GC62504 RAS/RAS-RAF-IN-1

GC62448 Rineterkib hydrochloride

GC62269 RRD-251

GC62206 PLX-4720-d7

GC61485 Raf inhibitor 2 Raf inhibitor 2 is a potent Raf kinase inhibitor with an IC50 of <1.0 μM.

GC37665 Sorafenib (D4)

GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib

GC37068 RAF mutant-IN-1

GC36223 HG6-64-1

GC35488 Belvarafenib TFA An inhibitor of B-RAF and C-RAF

GC19507 LUT-014 LUT-014 是一种 B-Raf 抑制剂，IC50 为 11.7 nM，用于减少与 EGFR 抑制剂治疗相关的剂量限制性痤疮样病变。

GC33206 ERK-IN-1

GC32950 Belvarafenib An inhibitor of B-RAF and C-RAF

GC32797 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

GC32686 PLX8394 PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.

GC19479 AZ304 AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制野生型 BRAF、V600E 突变型 BRAF 和野生型 CRAF，IC50 分别为 79 nM、38 nM 和 68 nM。 AZ304 对其他激酶也有显着影响，例如 p38 (IC50, 6 nM)、CSF1R (IC50, 35 nM)。抗肿瘤活性。

GC19307 RAF709 A potent inhibitor of B-RAF and C-RAF

GC19228 LXH254 A pan-RAF inhibitor

GC19091 CCT196969 A multi-kinase inhibitor

GC19066 BGB-283 BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.