JNK(c-Jun N-末端激酶)
JNK (c-Jun N-terminal kinase) is a group of kinases belong to the mitogen-activated protein kinase family and also play a role in T cell differentiation and the cellular apoptosis pathway.
- Cat.No. 产品名称 Information
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GC25982
Tanzisertib(CC-930)
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
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GC25521
IMM-H007
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
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GC63903
(E)-Osmundacetone
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GC49241
Methyl Diethyldithiocarbamate
An active metabolite of disulfiram
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GC62492
CC-90001
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GC60393
(-)-Zuonin A
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GC50400
CC 401 dihydrochloride
A potent, specific pan-JNK inhibitor
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GC46015
KY 05009
A TNIK inhibitor
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GC38679
Urolithin B
A metabolite of ellagic acid
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GC38202
DTP3 TFA
DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.
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GC38053
WHI-P258
A negative control for JAK3 inhibition
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GA20623
Ac-muramyl-Ala-D-Glu-NH₂
Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽,由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。
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GC36652
MPT0B392
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GC36359
J30-8
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GC36327
IQ-1S free acid
An inhibitor of NF-κB/AP-1
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GC36006
Esculentoside H
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GC35242
Actein
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GC45064
Tomatidine (hydrochloride)
A steroidal alkaloid with diverse biological activities
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GC44587
PDMP (hydrochloride)
An inhibitor of sphingolipid biosynthesis
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GC34275
L-JNKI-1
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GC33844
Isovitexin (Saponaretin)
A C-glycosylated flavone with diverse biological activities
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GC32983
Juglanin
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GC31647
Tomatidine
A steroidal alkaloid with diverse biological activities
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GC30864
SR-3306
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GC30057
D-JNKI-1 (AM-111)
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GC11157
LL-Z 1640-4
A negative control for MAPK signaling
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GC14938
PF-03394197(Oclacitinib)
A JAK family kinase inhibitor
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GC10010
AS601245
A potent JNK inhibitor used in cells and animals
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GC13244
DTP3
DTP3 TFA 是一种有效的选择性 GADD45β/MKK7 抑制剂。 DTP3 TFA 靶向 NF-κB 通路下游的一个重要的癌症选择性细胞存活模块。
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GC16652
SR 3576
A JNK3 inhibitor
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GC11542
SU 3327
A JNK1 inhibitor with antidiabetic and antibiotic activity
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GC17282
TCS JNK 6o
A JNK inhibitor
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GC17658
Guggulsterone
Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
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GC11559
Anisomycin
An antibiotic that inhibits protein and DNA synthesis
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GC13724
JIP-1 (153-163)
JIP-1 (153-163) (TI-JIP) 是 c-JNK 的肽抑制剂,基于 JNK-interacting protein-1 (JIP-1) 的残基 153-163(修改:Phe-11 \u003d C-末端酰胺)。
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GC12841
CEP 1347
CEP 1347 是一种具有神经保护作用的 JNK/SAPK 通路抑制剂。
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GC12674
IQ 3
IQ 3 是 c-Jun N-末端激酶 (JNK) 家族的特异性抑制剂,优先考虑 JNK3。
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GC12904
BI 78D3
A competitive inhibitor of JNK
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GC10204
AEG 3482
An inhibitor of p75NTR- and NRAGE-induced apoptosis
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GC10693
c-JUN peptide
JNK/c-Jun interaction inhibitor
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GC13529
CC-401
A potent, specific pan-JNK inhibitor
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GC11488
TCS JNK 5a
A selective inhibitor of JNK2 and JNK3
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GC15344
SP 600125
A pan-JNK inhibitor
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GC13841
JNK-IN-8
A selective, irreversible JNK inhibitor
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GC15028
JNK-IN-7
A non-selective JNK inhibitor
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GC14114
DB07268
A potent inhibitor of JNK1
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GC10446
CC-930
A potent JNK inhibitor
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GC14197
CC-401 hydrochloride
A potent, specific pan-JNK inhibitor
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GC12882
AS 602801
A selective, orally bioavailable JNK inhibitor
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GN10267
Loureirin B
A flavonoid with diverse biological activities