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JNK(c-Jun N-末端激酶)

JNK (c-Jun N-terminal kinase) is a group of kinases belong to the mitogen-activated protein kinase family and also play a role in T cell differentiation and the cellular apoptosis pathway.

  1. Cat.No. 产品名称 Information
  2. GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
  3. GC25521 IMM-H007 IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
  4. GC63903 (E)-Osmundacetone
  5. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram
  6. GC62492 CC-90001
  7. GC60393 (-)-Zuonin A
  8. GC50400 CC 401 dihydrochloride A potent, specific pan-JNK inhibitor
  9. GC46015 KY 05009 A TNIK inhibitor
  10. GC38679 Urolithin B A metabolite of ellagic acid
  11. GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.
  12. GC38053 WHI-P258 A negative control for JAK3 inhibition
  13. GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽,由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。
  14. GC36652 MPT0B392
  15. GC36359 J30-8
  16. GC36327 IQ-1S free acid An inhibitor of NF-κB/AP-1
  17. GC36006 Esculentoside H
  18. GC35242 Actein
  19. GC45064 Tomatidine (hydrochloride) A steroidal alkaloid with diverse biological activities
  20. GC44587 PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
  21. GC34275 L-JNKI-1
  22. GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities
  23. GC32983 Juglanin
  24. GC31647 Tomatidine A steroidal alkaloid with diverse biological activities
  25. GC30864 SR-3306
  26. GC30057 D-JNKI-1 (AM-111)
  27. GC11157 LL-Z 1640-4 A negative control for MAPK signaling
  28. GC14938 PF-03394197(Oclacitinib) A JAK family kinase inhibitor
  29. GC10010 AS601245 A potent JNK inhibitor used in cells and animals
  30. GC13244 DTP3 DTP3 TFA 是一种有效的选择性 GADD45β/MKK7 抑制剂。 DTP3 TFA 靶向 NF-κB 通路下游的一个重要的癌症选择性细胞存活模块。
  31. GC16652 SR 3576 A JNK3 inhibitor
  32. GC11542 SU 3327 A JNK1 inhibitor with antidiabetic and antibiotic activity
  33. GC17282 TCS JNK 6o A JNK inhibitor
  34. GC17658 Guggulsterone Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
  35. GC11559 Anisomycin An antibiotic that inhibits protein and DNA synthesis
  36. GC13724 JIP-1 (153-163) JIP-1 (153-163) (TI-JIP) 是 c-JNK 的肽抑制剂,基于 JNK-interacting protein-1 (JIP-1) 的残基 153-163(修改:Phe-11 \u003d C-末端酰胺)。
  37. GC12841 CEP 1347 CEP 1347 是一种具有神经保护作用的 JNK/SAPK 通路抑制剂。
  38. GC12674 IQ 3 IQ 3 是 c-Jun N-末端激酶 (JNK) 家族的特异性抑制剂,优先考虑 JNK3。
  39. GC12904 BI 78D3 A competitive inhibitor of JNK
  40. GC10204 AEG 3482 An inhibitor of p75NTR- and NRAGE-induced apoptosis
  41. GC10693 c-JUN peptide JNK/c-Jun interaction inhibitor
  42. GC13529 CC-401 A potent, specific pan-JNK inhibitor
  43. GC11488 TCS JNK 5a A selective inhibitor of JNK2 and JNK3
  44. GC15344 SP 600125 A pan-JNK inhibitor
  45. GC13841 JNK-IN-8 A selective, irreversible JNK inhibitor
  46. GC15028 JNK-IN-7 A non-selective JNK inhibitor
  47. GC14114 DB07268 A potent inhibitor of JNK1
  48. GC10446 CC-930 A potent JNK inhibitor
  49. GC14197 CC-401 hydrochloride A potent, specific pan-JNK inhibitor
  50. GC12882 AS 602801 A selective, orally bioavailable JNK inhibitor
  51. GN10267 Loureirin B A flavonoid with diverse biological activities

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