JNK(c-Jun N-末端激酶)

Cat.No. 产品名称 Information

GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

GC25521 IMM-H007 IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.

GC63903 (E)-Osmundacetone

GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram

GC62492 CC-90001

GC60393 (-)-Zuonin A

GC50400 CC 401 dihydrochloride A potent, specific pan-JNK inhibitor

GC46015 KY 05009 A TNIK inhibitor

GC38679 Urolithin B A metabolite of ellagic acid

GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

GC38053 WHI-P258 A negative control for JAK3 inhibition

GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽，由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。

GC36652 MPT0B392

GC36359 J30-8

GC36327 IQ-1S free acid An inhibitor of NF-κB/AP-1

GC36006 Esculentoside H

GC35242 Actein

GC45064 Tomatidine (hydrochloride) A steroidal alkaloid with diverse biological activities

GC44587 PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis

GC34275 L-JNKI-1

GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities

GC32983 Juglanin

GC31647 Tomatidine A steroidal alkaloid with diverse biological activities

GC30864 SR-3306

GC30057 D-JNKI-1 (AM-111)

GC11157 LL-Z 1640-4 A negative control for MAPK signaling

GC14938 PF-03394197(Oclacitinib) A JAK family kinase inhibitor

GC10010 AS601245 A potent JNK inhibitor used in cells and animals

GC13244 DTP3 DTP3 TFA 是一种有效的选择性 GADD45β/MKK7 抑制剂。 DTP3 TFA 靶向 NF-κB 通路下游的一个重要的癌症选择性细胞存活模块。

GC16652 SR 3576 A JNK3 inhibitor

GC11542 SU 3327 A JNK1 inhibitor with antidiabetic and antibiotic activity

GC17282 TCS JNK 6o A JNK inhibitor

GC17658 Guggulsterone Guggulsterone 是一种植物甾醇，来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin），调节细胞周期蛋白（cyclin D1 和c-Myc)，激活半胱天冬酶和 JNK，抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。