Neuroscience(神经科学)
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more
Products for Neuroscience
- 5-HT Receptor(410)
- AChR(53)
- AChE(101)
- Alzheimer(105)
- Amyloid β(119)
- BACE(4)
- CGRP (32)
- COX(293)
- DAPK(5)
- Dopamine Receptor(290)
- GABA Receptor(152)
- Gap Junction(16)
- GluR(117)
- Histamine(2)
- Histamine Receptor(232)
- mPEGS-1(4)
- Muscarinic Receptor(41)
- Neuroscience Peptides(38)
- Nicotinic Receptor(63)
- P2 Receptor(2)
- P2X7 receptor(3)
- SSRIs(5)
- Substance P/NK1 Receptor(20)
- NMDA(2)
- Beta-secretase(24)
- CaMK(33)
- Dopamine Transporter(19)
- Monoamine Oxidase(85)
- Serotonin Transporter(57)
- nAChR(97)
- iGluR(154)
- Neurokinin Receptor(73)
- MCHR1 (GPR24)(16)
- mAChR(179)
- GPR139(4)
- Cholecystokinin Receptor(25)
- Behavioral Neuroscience(345)
- DREADD(1)
- Huntington(14)
- Neuroendocrinology(58)
- Neuroprotection(115)
- Ophthalmology(158)
- Pain Research(221)
- Parkinson(71)
- Prion(7)
- Seizure Disorders(94)
- Cholinesterases(13)
- Neurodegenerative Disorders(3)
- Cat.No. 产品名称 Information
- GC91849 Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
- GC91703 AL 34662 (formate) AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2.
- GC91690 TASP0277308 TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).
- GC91681 Loxoprofen-SRS Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen .
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GC91680
4-Acetamido Antipyrine
4-AAAP,NSC 331807
4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole . - GC91641 4-Hydroxy-1-(2-phenylethyl)piperidine 4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).
- GC91621 WLB-89462 WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).
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GC91544
Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH
Fmoc-Lys(tBuOCO-(CH2)16-CO-Glu(AEEA-AEEA)-OtBu)-OH
Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide . - GC91507 CP 93,129 CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B.
- GC91497 EB 47 (hydrochloride) EB 47 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 45 nM) and a dual site inhibitor of tankyrase 2 (TNKS2; IC50 = 45 nM).
- GC91493 Semaglutide Side Chain Semaglutide side chain is a synthetic intermediate.
- GC91492 Propiverine N-oxide Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine .
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GC91488
Proxymetacaine (hydrochloride)
Proparacaine
Proxymetacaine is an anesthetic. - GC72723 p-Hydroxybenzaldehyde-d4 p-Hydroxybenzaldehyde-d4是氘标记的对羟基苯甲醛。
- GC72625 (±)-Coniine hydrochloride (±)-Coniine hydrochloride2-丙基哌啶盐酸盐是一种强效的nAChR激动剂,EC50值为0.3mM。
- GC72617 hMAO-B-IN-5 hMAO-B-IN-5(B15)是一种强效、选择性和可逆的人单胺氧化酶hMAO-B抑制剂,IC50为0.12μM。
- GC72246 αC-Conotoxin PrXA αC-Conotoxin PrXA是一种麻痹性肽神经毒素和竞争性nAChR拮抗剂,IC50分别为1.8 nM(α1β1εδ,成人)和3.0 nM(β1γδ,胎儿)。
- GC72222 Survodutide Survodutide(BI 456906)是一种强效的选择性胰高血糖素受体/GLP-1受体(GCGR/GLP-1R)双重激动剂,在CHO-K1细胞中的EC50分别为0.52 nM和0.33 nM。
- GC72212 Substance P (5-11) (TFA) Substance P (5-11) (TFA)TFA是P物质P的C末端七肽,是一种神经肽。
- GC72206 Autocamtide-3 acetate Autocamtide-3 acetate含有Thr287的13个氨基酸的肽是选择性CaMKII(Ca2+/钙调素依赖性激酶II)(CaMK)底物。
- GC72190 Cagrilintide Cagrilintide是一种正在研究的新型长效酰化amylin类似物,作为非选择性amylin受体(AMYR)和降钙素G蛋白偶联受体(CTR)激动剂。
- GC72117 FITC-α-Bungarotoxin FITC-α-Bungarotoxin为FITC标记的α-Bungarotoxin。
- GC72115 [D-Pro2] Spantide I TFA [D-Pro2] Spantide I TFA是Spantide的类似物。
- GC72110 α-CGRP(human) TFA α-CGRP(human) TFA是一种由37个氨基酸组成的调节神经肽。
- GC72093 α-CGRP (mouse, rat) (TFA) α-CGRP (mouse, rat) (TFA),一种主要在神经肌肉接头表达的神经肽降钙素基因相关肽CGRP,是一种强效的血管舒张剂。
- GC72054 Obovatol Obovatol是一种从厚朴叶中分离出来的联苯醚木脂素。
- GC71717 Cinitapride Cinitapride是非选择性5-HT1和5-HT4受体激动剂和5-HT2和D2拮抗剂。
- GC71684 Propantheline-d3 bromide Propantheline-d3 bromide是氘标记的溴化丙烷。
- GC71660 Tiotropium bromide monohydrate Tiotropium bromide monohydrate是一种抗胆碱能和支气管扩张剂,也是毒蕈碱受体拮抗剂。
- GC71653 Domperidone monomaleate Domperidone monomaleate是一种口服活性和选择性多巴胺-2受体拮抗剂。
- GC71641 Tropicamide-d3 Tropicamide-d3是氘标记的托吡卡胺。
- GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride盐酸奥昔布宁的R-异构体,是一种口服活性毒蕈碱受体拮抗剂。
- GC71620 Venlafaxine-d6 Venlafaxine-d6是氘标记的文拉法辛。
- GC71618 rel-Sertraline-d3 hydrochloride rel-Sertraline-d3 hydrochloride是氘标记的盐酸舍曲林。
- GC71604 Ondansetron-d3 hydrochloride Ondansetron-d3 hydrochloride是氘标记的盐酸昂丹司琼。
- GC71603 Ondansetron-d5 Ondansetron-d5是氘标记的昂丹司琼。
- GC71602 Propyphenazone-d3 Propyphenazone-d3是氘标记的苯丙酮。
- GC71594 Tolterodine-d14 hydrochloride Tolterodine-d14 hydrochloride是氘标记的盐酸托特罗定。
- GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-Hydroxymethyl Tolterodine hydrochloride是托特罗定的活性代谢产物,是mAChR拮抗剂。
- GC71523 Enerisant hydrochloride Enerisant hydrochloride是一种选择性、竞争性和口服活性的组胺H3受体(HRH3)拮抗剂/反向激动剂,对人和大鼠HRH3的IC50分别为2.89 nM和14.5 nM。
- GC71511 Dexpramipexole-d3 dihydrochloride Dexpramipexole-d3 dihydrochloride是氘标记的右旋普拉克索。
- GC71497 ZCAN262 ZCAN262(化合物6)是AMPA调制器。
- GC71484 MAO-B-IN-30 MAO-B-IN-30(化合物IS7)是一种强效、选择性和跨血脑屏障的MAO-B抑制剂,MAO-a和MAO-B的IC50值分别为19.176和0.082µM。
- GC71436 Brexpiprazole-d8-1 Brexpiprazole-d8-1是氘标记的布雷哌唑。
- GC71334 mAChR antagonist 1 mAChR antagonist 1(化合物4a)是一种mAChR拮抗剂,对M1、M3、M4和M5亚型的Ki值分别为255 nM、121 nM、158 nM和255 nM。
- GC71317 Z1078601926 Z1078601926是人多巴胺转运蛋白(hDAT)的变构抑制剂。
- GC71283 (Rac)-Rotigotine (Rac)-Rotigotine N-0437是罗替戈汀的外消旋物。
- GC71279 5-HT2A receptor agonist-3 5-HT2A receptor agonist-3Ki=2.5nM、对5-HT2A的选择性是结构相似的5-HT2C受体的124倍。
- GC71160 MAO-A/5-HT2AR-IN-1 MAO-A/5-HT2AR-IN-1(化合物I14)是一种强效的MAO-a和5-HT2AR双重抑制剂,IC50值分别为0.004和0.014μM。
- GC71157 Dopamine D2 receptor agonist-2 Dopamine D2 receptor agonist-2(化合物36)是一种有效的多巴胺D2受体偏向性激动配体,Ki值为11.2 nM。