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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC26093 α-Conotoxin GI α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.
  3. GC26056 WAY-303290 WAY-303290 (GluR6 antagonist-1) is a benzothiophene derivative acting as an ionotropic glutamate receptor 6 (GluR6) antagonist, which can be used for researching acute and chronic neurological disorders.
  4. GC26035 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
  5. GC26032 Varenicline (CP 526555) dihydrochloride Varenicline (CP 526555, Chantix, Champix,CP 526555 dihydrochloride) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
  6. GC26002 Trazodone Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
  7. GC25994 Thonzylamine Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.
  8. GC25898 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
  9. GC25785 Promethazine Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
  10. GC25756 Pirenperone Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
  11. GC25708 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
  12. GC25618 Maropitant citrate Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties
  13. GC25583 Lobelin sulphate Lobelin sulphate (Lobeline sulfate, Bantron) is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
  14. GC25571 Levocetirizine Levocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor.
  15. GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.
  16. GC25566 L-DAB HBR L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM
  17. GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.
  18. GC25531 Isonipecotic acid Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
  19. GC25434 Frovatriptan Succinate Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.
  20. GC25387 Ethyl (triphenylphosphoranylidene) acetate Ethyl (triphenylphosphoranylidene) acetate (Triphenylcarbethoxymethylenephosphorane, (Carbethoxymethylene)triphenylphosphorane) may act as an inhibitor of cholinesterase that inhibits AChE and BChE.
  21. GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
  22. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors
  23. GC25136 Betazole Dihydrochloride Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
  24. GC25060 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
  25. GC67996 TPA-023B
  26. GC67995 Ketotifen-d3 fumarate
  27. GC67989 (S)-Mirtazapine
  28. GC67979 MK-6884
  29. GC67944 Cetirizine D4
  30. GC67937 (R)-Mirtazapine
  31. GC67923 Renzapride
  32. GC67922 Zelquistinel
  33. GC67882 VU6028418
  34. GC67752 Pimozide-d4-1
  35. GC67705 Naxagolide
  36. GC52514 Arachidonic Acid-d11 ethyl ester An internal standard for the quantification of arachidonic acid ethyl ester
  37. GC52507 Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt) A hypothalamic neuropeptide
  38. GC52505 Ganglioside GT1b (bovine) (sodium salt) A sphingolipid
  39. GC52502 Peptide YY (3-36) (trifluoroacetate salt) A satiety hormone
  40. GC52500 Dynorphin A (trifluoroacetate salt) An endogenous opioid receptor agonist
  41. GC52498 NGB 2904 (hydrochloride) A selective D3 antagonist
  42. GC52497 Lactosylceramide (porcine RBC) A sphingolipid
  43. GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides
  44. GC52495 AF-353 (hydrochloride) A dual P2X3 and P2X2/3 receptor antagonist
  45. GC52494 β-Endorphin (rat) (trifluoroacetate salt) An opioid neuropeptide
  46. GC52493 Glucosylceramide (bovine buttermilk) A sphingolipid
  47. GC52492 Globotriaosylceramide (hydroxy) (porcine RBC) A sphingolipid
  48. GC52491 Globotriaosylceramide (non-hydroxy) (porcine RBC) A sphingolipid
  49. GC52487 Ganglioside GM4 (chicken egg) (ammonium salt) A sphingolipid
  50. GC52486 Ceramide Phosphoethanolamine (bovine) A sphingolipid
  51. GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides

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