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CaMK(钙调蛋白激酶)

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

Products for  CaMK

  1. Cat.No. 产品名称 Information
  2. GC49440 ML-9 A PKB/Akt inhibitor
  3. GC62146 XST-14 XST-14 是一种有效的,竞争性强且高度选择性的 ULK1 抑制剂,IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡,并具有抗肿瘤作用。
  4. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂,抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
  5. GC60037 A-3 hydrochloride A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  6. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated Autocamtide-2 相关抑制肽,肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。
  7. GC37710 Syntide 2 (TFA) A protein kinase substrate
  8. GC37694 STO-609 A CaMKK inhibitor
  9. GC35820 DDD107498 succinate DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
  10. GC35601 CaMKII-IN-1 CaMKII-IN-1是CaMKII高效选择性抑制剂,IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
  11. GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
  12. GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
  13. GC33775 Rimacalib (SMP 114) Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂,IC50 为 ~1 μ;M 代表 CaMKIIα;至 ~30 μ;M 代表 CaMKIIγ;。
  14. GC33732 Syntide 2 A protein kinase substrate
  15. GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。
  16. GC31170 Calmodulin-Dependent Protein Kinase II 290-309

    A CaMKII inhibitor

  17. GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。
  18. GC12804 KN-93 Phosphate A CaMKII inhibitor
  19. GC12739 A 484954 An eEF-2K inhibitor
  20. GC17329 MLCK inhibitor peptide 18 A selective, cell-permeable inhibitor of MLCK
  21. GC14326 Calmidazolium chloride An inhibitor of calmodulin
  22. GC11362 K 252a A non-selective PKC inhibitor
  23. GC12501 KN-93 hydrochloride A selective inhibitor of Ca2+/calmodulin-dependent kinase type II
  24. GC13793 NH125 An antibacterial imidazole
  25. GC10629 KN-93 Selective inhibitor of Ca2+/calmodulin-dependent kinase type II
  26. GC16981 KN-92 phosphate KN-92 phosphate 是 KN-93 的无活性衍生物,没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
  27. GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor
  28. GC14132 KN-92 An inactive control compound for a CaMKII inhibitor
  29. GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II

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