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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC68996 Donanemab Donanemab (LY3002813) 是一种针对 N 末端焦谷氨酸β淀粉样蛋白 (Aβ) 表位的人源化 IgG1 单克隆抗体。Donanemab 具有用于早期阿尔茨海默病研究的潜力。
  3. GC68985 Diphenhydramine-d6 hydrochloride Diphenhydramine-d6 (hydrochloride) 是 Diphenhydramine hydrochloride 的氘代物。Diphenhydramine hydrochloride 是第一代具有抗胆碱能作用的组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Diphenhydramine hydrochloride 能透过血脑屏障。
  4. GC68984 Diphenhydramine-d5 hydrochloride Diphenhydramine-d5 (hydrochloride) 是 Diphenhydramine hydrochloride 的氘代物。Diphenhydramine hydrochloride 是第一代具有抗胆碱能作用的组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Diphenhydramine hydrochloride 能透过血脑屏障。
  5. GC68954 Decanoic acid-d5 Decanoic acid-d5 是 Decanoic acid 氘代物。Decanoic acid 是中链甘油三酯中的一种成分，是一种可透过血脑屏障的 AMPA 受体的非竞争性抑制剂。Decanoic acid 具有抗癫痫作用。
  6. GC68931 Cytidine 5′-diphosphoethanolamine Cytidine 5′-diphosphoethanolamine 是合成磷脂酰乙醇胺的中间化合物。Cytidine 5′-diphosphoethanolamine 是乙酰胆碱合成的刺激剂。
  7. GC68869 Cipralisant maleate Cipralisant (GT-2331) (maleate) 在体内是一种具有口服活性、低毒、有效、选择性、高亲和力的 histamine H3 receptor 的拮抗剂，在体外是 histamine H3 receptor 的激动剂，对于 histamine H3 receptor，其 pKi 为 9.9，对大鼠 histamine H3 receptor 的Ki为 0.47 nM。Cipralisant (maleate) 有研究注意缺陷多动障碍的潜力。
  8. GC68868 Cipralisant (enantiomer) Cipralisant (GT-2331) enantiomer 是 Cipralisant 的对映异构体，Cipralisant 是一种具有口服活性的、有效的、选择性的、高亲和力的 histamine H3 receptor 拮抗剂 (rat Ki=0.47 nM)。
  9. GC68849 Celecoxib-d3 Celecoxib-d3 是 Celecoxib 的氘代物。Celecoxib 是一种选择性的 COX-2 抑制剂，IC50 为 40 nM。
  10. GC68821 Cagrilintide acetate Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。
  11. GC68806 Brexpiprazole S-oxide-d8 Brexpiprazole S-oxide-d8 是 Brexpiprazole S-oxide 的氘代物。Brexpiprazole S-oxide 是 Brexpiprazole 的主要代谢产物，并通过细胞色素 P450 3A4 (CYP3A4) 代谢。Brexpiprazole 是一种非典型抗精神病药，是人 5-HT1A 和多巴胺受体的部分激动剂，Ki 分别为 0.12 nM 和 0.3 nM。Brexpiprazole 也是 5-HT2A 受体的拮抗剂，Ki 为 0.47 nM。
  12. GC68798 BPDBA BPDBA 是一种选择性和非竞争性 betaine/GABA 转运体 (BGT-1) 抑制剂，对人 BGT-1 和小鼠 GAT2 的 IC50 分别为 20 μM 和 35 μM。
  13. GC68725 Bapineuzumab Bapineuzumab 是一种抗 β-淀粉样蛋白 (APP) 单克隆抗体。Bapineuzumab 可用于阿尔茨海默病 (AD) 的研究。
  14. GC68721 Aβ/tau aggregation-IN-3 Aβ/tau aggregation-IN-3 是一种有效的淀粉样蛋白聚集抑制剂，通过 Aβ-硫黄素 T (Aβ-ThT) 功能聚集测定，IC50 为 0.85 μM。Aβ/tau aggregation-IN-3 具有抗淀粉样蛋白活性。
  15. GC68714 AZD4694 AZD4694 (NAV4694) 是一种氟化 β-淀粉样蛋白 (Aβ) 斑块神经成像的 PET 放射配基，对 Aβ纤维具有高度亲和力 (Kd = 2.3 nM)。
  16. GC68687 Aripiprazole-d8 Aripiprazole-d8 是 Aripiprazole 的氘代物。
  17. GC68659 Anisatin Anisatin 从一种日本植物 Illicium anisatum) 种子中分离出来的一种有毒物质，是一种类苦毒素的非竞争性 b>GABA 抗剂。Anisatin 以浓度依赖性方式抑制 GABA 诱导的电流，EC50 约为 1.10 μM。
  18. GC68609 AChE-IN-26 AChE-IN-26 (compound 4a) 是 AChE (acetylcholinesterase) 的抑制剂，IC50 值为 0.42 μM。AChE-IN-26 可用于阿尔兹海默症的研究。
  19. GC68608 AChE/BChE-IN-10 AChE/BChE-IN-10 (Compound 7b) 是一种有效的 AChE 和 BChE 双重抑制剂，IC50 值分别为 0.176 和 0.47 μM。AChE/BChE-IN-10 显示出良好的血脑屏障渗透性。AChE/BChE-IN-10 可以抑制 Aβ 的聚集，可用于阿尔茨海默病的研究。
  20. GC68602 Acetylcholine-d13 bromide Acetylcholine-d13 (bromide) 是 Acetylcholine bromide 的氘代物。
  21. GC26093 α-Conotoxin GI α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.
  22. GC26056 WAY-303290 WAY-303290 (GluR6 antagonist-1) is a benzothiophene derivative acting as an ionotropic glutamate receptor 6 (GluR6) antagonist, which can be used for researching acute and chronic neurological disorders.
  23. GC26035 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
  24. GC26032 Varenicline (CP 526555) dihydrochloride Varenicline (CP 526555, Chantix, Champix,CP 526555 dihydrochloride) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
  25. GC26002 Trazodone Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
  26. GC25994 Thonzylamine Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.
  27. GC25898 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
  28. GC25785 Promethazine Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
  29. GC25756 Pirenperone Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
  30. GC25708 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
  31. GC25618 Maropitant citrate Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties
  32. GC25583 Lobelin sulphate Lobelin sulphate (Lobeline sulfate, Bantron) is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
  33. GC25571 Levocetirizine Levocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor.
  34. GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.
  35. GC25566 L-DAB HBR L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM
  36. GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.
  37. GC25531 Isonipecotic acid Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
  38. GC25434 Frovatriptan Succinate Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.
  39. GC25387 Ethyl (triphenylphosphoranylidene) acetate Ethyl (triphenylphosphoranylidene) acetate (Triphenylcarbethoxymethylenephosphorane, (Carbethoxymethylene)triphenylphosphorane) may act as an inhibitor of cholinesterase that inhibits AChE and BChE.
  40. GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
  41. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors
  42. GC25136 Betazole Dihydrochloride Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
  43. GC25060 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
  44. GC68438 AMPA receptor modulator-3 AMPA receptor modulator-3 是一种变构的 AMPA 受体调节剂 (EC50: 4.4 μM)。AMPA receptor modulator-3 可用于哺乳动物神经系统的研究，如学习和记忆能力。
  45. GC68423 Indomethacin-d4 Methyl Ester Indomethacin-d4 Methyl Ester 是 Indomethacin 的氘代物。Indomethacin (Indometacin) 是一种有效的，可透过血脑屏障的，非选择性的 COX1 和 COX2 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 18 nM 和 26 nM。Indomethacin 通过干扰溶酶体的正常功能来破坏自噬流 (autophagic flux)。
  46. GC68422 Choline-d4 chloride Choline-d4 chloride 是 Choline chloride 的氘代物。Choline chloride是一种有机化合物和季铵盐, 是酰基受体和胆碱乙酰转移酶的底物, 是一种植物光合作用促进剂, 也作禽畜饲料添加剂, 刺激产蛋产仔。
  47. GC68420 Propionylpromazine-d6 hydrochloride Propionylpromazine-d6 hydrochloride 是 Propionylpromazine hydrochloride 的氘代物。Propionylpromazine hydrochloride (Propiopromazine hydrochloride) 是一种多巴胺受体 D2 (DRD2) 拮抗剂，可用于帕金森氏病的研究。
  48. GC68410 (S)-Mirtazapine-d3 (S)-Mirtazapine D3 ((S)-Org3770 D3) 是 (S)-Mirtazapine 氘代物。(S)-Mirtazapine 是 Mirtazapine 的 S(+)-对映异构体，在急性热伤害感受动物模型中具有促伤害感受的特性。(S)-Mirtazapine 是一种立体选择性 5-HT2 受体拮抗剂，在体内被 CYP2D6 和 CYP1A2 代谢。
  49. GC68409 Cetirizine D8 Cetirizine D8 是Cetirizine 的氘代物。Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。
  50. GC68383 (R)-Preclamol (R)-Preclamol 是一种多巴胺 (DA) 激动剂，具有自身受体和突触后受体刺激特性。(R)-Preclamol 以低剂量抑制小鼠和大鼠的运动活动。
  51. GC68377 OAB-14 OAB-14 是一种 Bexarotene 衍生物，通过增加 APP/PS1 小鼠的 β-淀粉样蛋白清除率，改善阿尔茨海默病相关的病理学和认知障碍。OAB-14 可有效改善 APP/PS1 转基因小鼠内体自噬溶酶体途径的功能障碍。

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