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Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC52496 Sulfatide (bovine) (sodium salt)

    Galactosylceramide I3-sulfate, Ganglioside SM4, I3SO3-GalCer, SM4, Sulfated Galactocerebroside, 3-O-Sulfogalactosylceramide

    A mixture of isolated bovine sulfatides
  3. GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
  4. GC52172 5-hydroxy Indole-3-acetic Acid-d6

    5-HIAA-d6, 5-Hydroxyindoleacetic Acid-d6, 5-hydroxy IAA-d6

    An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
  5. GC52078 Galantamine (hydrobromide)

    氢溴酸加兰他敏

    An alkaloid with AChE inhibitory and nAChR potentiating activities

  6. GC52047 Fustin

    黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone

    A flavanone with diverse biological activities
  7. GC52027 Isolariciresinol

    异落叶松脂素,(+)-Cyclolariciresinol

    A lignan with diverse biological activities
  8. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

    A neuroprotective ADNP-derived peptide
  9. GC49815 Oleuropein aglycone

    3,4-DHPEA-EA

    A polyphenol with diverse biological activities
  10. GC49557 Cu-GTSM

    CuII(gtsm), copper-GTSM

    A copper-containing compound with diverse biological activities
  11. GC49493 IRL 1620 (trifluoroacetate salt)

    PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)

    A peptide ETB receptor agonist
  12. GC49461 L-Serine-d7

    L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7

    An internal standard for the quantification of L-serine
  13. GC49436 L-3-n-Butylphthalide

    (–)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(–)-3-Butylphthalide, L-NBP

    A phthalide with antiplatelet and neuroprotective activities
  14. GC49417 L-Serine-13C3

    L-丝氨酸-13C3,(-)-Serine-13C3; (S)-Serine-13C3

    An internal standard for the quantification of L-serine
  15. GC49306 Isopimaric Acid

    异海松酸

    A diterpenoid resin acid
  16. GC49273 Glycerophosphorylethanolamine (sodium salt)

    Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine

    An active metabolite of phosphatidylethanolamine
  17. GC49192 Piracetam-d6

    UCB-6215-d6

    An internal standard for the quantification of piracetam
  18. GC49108 Racecadotril-d5

    消旋卡多曲杂质,Acetorphan-d5

    An internal standard for the quantification of racecadotril
  19. GC49090 Nilvadipine-d4

    (±)-Nilvadipine-d4

    An internal standard for the quantification of nilvadipine
  20. GC49024 Palmitic Acid MaxSpec® Standard

    棕榈酸

    A long-chain saturated fatty acid
  21. GC49023 Palmitic Acid-d9 MaxSpec® Standard

    棕榈酸-13,13,14,14,15,15,16,16,16-D9

    A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
  22. GC48969 Withanone

    NSC 179884

    A phytochemical with diverse biological activities
  23. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
  24. GC48028 Rasagiline-13C3 (mesylate)

    甲磺酸雷沙吉兰-13C3

    An internal standard for the quantification of rasagiline
  25. GC47955 Phloroglucinol

    间苯三酚

    A phenol with diverse biological activities
  26. GC47746 NAP 226-90

    3-(1-(S)-(N,N-二甲基氨基)乙基)苯酚

    A metabolite of rivastigmine
  27. GC47563 L-Glutamic Acid (ammonium salt)

    谷氨酸一铵

    An excitatory neurotransmitter
  28. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
  29. GC47264 Donepezil-d4 (hydrochloride)

    多奈哌齐-D4,E2020-d4

    An internal standard for the quantification of donepezil
  30. GC47263 Donecopride (fumarate hydrate)

    MR31147

    A 5-HT4 receptor partial agonist and AChE inhibitor
  31. GC47186 Deoxy Donepezil (hydrochloride)

    1-苄基-4-((5,6-二甲氧基-2,3-二氢-1H-茚-2-基)甲基)哌啶盐酸盐

    A potential impurity found in bulk preparations of donepezil
  32. GC46997 C22 Galactosylceramide (d18:1/22:0)

    N-Docosanoyl-β-D-Galactosylceramide, Galactosylceramide (d18:1/22:0), GalCer(d18:1/22:0)

    A sphingolipid
  33. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Aβ (1-42), Aβ42

    A 42-amino acid protein fragment of amyloid-β
  34. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine

    NSC 1227

    A synthetic intermediate in the synthesis of AChE inhibitors
  35. GC46451 16F16 A PDI inhibitor
  36. GC46208 Propentofylline

    普罗潘非林,HWA 285

    A xanthine derivative and neuroprotective agent
  37. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
  38. GC45831 SRI-011381 A TGF-β signaling activator
  39. GC45765 Deferiprone-d3

    去铁酮 d3

    An internal standard for the quantification of deferiprone
  40. GC45378 Alaproclate (hydrochloride)

    阿拉丙酯盐酸盐

    An SSRI
  41. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

    A metabolite of valproic acid
  42. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    TAMRA-Aβ42, TAMRA-Aβ (1-42)

    A fluorescently labeled amyloid-β peptide
  43. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
  44. GC44674 Pramlintide (acetate hydrate)

    醋酸普兰林肽

    An amylin analog
  45. GC44416 N-methyl Mesoporphyrin IX

    N-甲基中卟啉IX

    A ferrochelatase inhibitor and turn-on biosensor for DNA
  46. GC44399 NIAD-4 A fluorescent probe for Aβ
  47. GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
  48. GC43708 Fulvic Acid

    富里酸

    A fungal metabolite
  49. GC43700 FSB A fluorescent probe
  50. GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
  51. GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β

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