Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for Alzheimer

Cat.No. 产品名称 Information
GC52496 Sulfatide (bovine) (sodium salt)
Galactosylceramide I3-sulfate, Ganglioside SM4, I3SO3-GalCer, SM4, Sulfated Galactocerebroside, 3-O-Sulfogalactosylceramide
A mixture of isolated bovine sulfatides
GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
GC52172 5-hydroxy Indole-3-acetic Acid-d6
5-HIAA-d6, 5-Hydroxyindoleacetic Acid-d6, 5-hydroxy IAA-d6
An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
GC52078 Galantamine (hydrobromide)
氢溴酸加兰他敏

An alkaloid with AChE inhibitory and nAChR potentiating activities
GC52047 Fustin
黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
A flavanone with diverse biological activities
GC52027 Isolariciresinol
异落叶松脂素,(+)-Cyclolariciresinol
A lignan with diverse biological activities
GC49913 Davunetide (acetate)
AL-108, NAP, NAPVSIPQ
A neuroprotective ADNP-derived peptide
GC49815 Oleuropein aglycone
3,4-DHPEA-EA
A polyphenol with diverse biological activities
GC49557 Cu-GTSM
CuII(gtsm), copper-GTSM
A copper-containing compound with diverse biological activities
GC49493 IRL 1620 (trifluoroacetate salt)
PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)
A peptide ET_B receptor agonist
GC49461 L-Serine-d7
L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7
An internal standard for the quantification of L-serine
GC49436 L-3-n-Butylphthalide
(–)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(–)-3-Butylphthalide, L-NBP
A phthalide with antiplatelet and neuroprotective activities
GC49417 L-Serine-13C3
L-丝氨酸-13C3,(-)-Serine-13C3; (S)-Serine-13C3
An internal standard for the quantification of L-serine
GC49306 Isopimaric Acid
异海松酸
A diterpenoid resin acid
GC49273 Glycerophosphorylethanolamine (sodium salt)
Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine
An active metabolite of phosphatidylethanolamine
GC49192 Piracetam-d6
UCB-6215-d6
An internal standard for the quantification of piracetam
GC49108 Racecadotril-d5
消旋卡多曲杂质,Acetorphan-d5
An internal standard for the quantification of racecadotril
GC49090 Nilvadipine-d4
(±)-Nilvadipine-d4
An internal standard for the quantification of nilvadipine
GC49024 Palmitic Acid MaxSpec® Standard
棕榈酸
A long-chain saturated fatty acid
GC49023 Palmitic Acid-d9 MaxSpec® Standard
棕榈酸-13,13,14,14,15,15,16,16,16-D9
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC48969 Withanone
NSC 179884
A phytochemical with diverse biological activities
GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
GC48028 Rasagiline-13C3 (mesylate)
甲磺酸雷沙吉兰-13C3
An internal standard for the quantification of rasagiline
GC47955 Phloroglucinol
间苯三酚
A phenol with diverse biological activities
GC47746 NAP 226-90
3-(1-(S)-(N,N-二甲基氨基)乙基)苯酚
A metabolite of rivastigmine
GC47563 L-Glutamic Acid (ammonium salt)
谷氨酸一铵
An excitatory neurotransmitter
GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
GC47264 Donepezil-d4 (hydrochloride)
多奈哌齐-D4,E2020-d4
An internal standard for the quantification of donepezil
GC47263 Donecopride (fumarate hydrate)
MR31147
A 5-HT₄ receptor partial agonist and AChE inhibitor
GC47186 Deoxy Donepezil (hydrochloride)
1-苄基-4-((5,6-二甲氧基-2,3-二氢-1H-茚-2-基)甲基)哌啶盐酸盐
A potential impurity found in bulk preparations of donepezil
GC46997 C22 Galactosylceramide (d18:1/22:0)
N-Docosanoyl-β-D-Galactosylceramide, Galactosylceramide (d18:1/22:0), GalCer(d18:1/22:0)
A sphingolipid
GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt)
Aβ (1-42), Aβ42
A 42-amino acid protein fragment of amyloid-β
GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine
NSC 1227
A synthetic intermediate in the synthesis of AChE inhibitors
GC46451 16F16 A PDI inhibitor
GC46208 Propentofylline
普罗潘非林,HWA 285
A xanthine derivative and neuroprotective agent
GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
GC45831 SRI-011381 A TGF-β signaling activator
GC45765 Deferiprone-d3
去铁酮 d3
An internal standard for the quantification of deferiprone
GC45378 Alaproclate (hydrochloride)
阿拉丙酯盐酸盐
An SSRI
GC45137 Valproic Acid Acyl-D-Glucuronide
Valproic Acid Gluclonide
A metabolite of valproic acid
GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
TAMRA-Aβ42, TAMRA-Aβ (1-42)
A fluorescently labeled amyloid-β peptide
GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
GC44674 Pramlintide (acetate hydrate)
醋酸普兰林肽
An amylin analog
GC44416 N-methyl Mesoporphyrin IX
N-甲基中卟啉IX
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K_d值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
GC44399 NIAD-4 A fluorescent probe for Aβ
GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
GC43708 Fulvic Acid
富里酸
A fungal metabolite
GC43700 FSB A fluorescent probe
GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β