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Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

  1. Cat.No. 产品名称 Information
  2. GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides
  3. GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
  4. GC52172 5-hydroxy Indole-3-acetic Acid-d6 An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
  5. GC52078 Galantamine (hydrobromide)

    An alkaloid with AChE inhibitory and nAChR potentiating activities

  6. GC52047 Fustin A flavanone with diverse biological activities
  7. GC52027 Isolariciresinol A lignan with diverse biological activities
  8. GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide
  9. GC49815 Oleuropein aglycone A polyphenol with diverse biological activities
  10. GC49557 Cu-GTSM A copper-containing compound with diverse biological activities
  11. GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist
  12. GC49461 L-Serine-d7 An internal standard for the quantification of L-serine
  13. GC49436 L-3-n-Butylphthalide A phthalide with antiplatelet and neuroprotective activities
  14. GC49417 L-Serine-13C3 An internal standard for the quantification of L-serine
  15. GC49306 Isopimaric Acid A diterpenoid resin acid
  16. GC49273 Glycerophosphorylethanolamine (sodium salt) An active metabolite of phosphatidylethanolamine
  17. GC49192 Piracetam-d6 An internal standard for the quantification of piracetam
  18. GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
  19. GC49090 Nilvadipine-d4 An internal standard for the quantification of nilvadipine
  20. GC49024 Palmitic Acid MaxSpec® Standard A long-chain saturated fatty acid
  21. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
  22. GC48969 Withanone A phytochemical with diverse biological activities
  23. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
  24. GC48028 Rasagiline-13C3 (mesylate) An internal standard for the quantification of rasagiline
  25. GC47955 Phloroglucinol A phenol with diverse biological activities
  26. GC47746 NAP 226-90 A metabolite of rivastigmine
  27. GC47563 L-Glutamic Acid (ammonium salt) An excitatory neurotransmitter
  28. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
  29. GC47264 Donepezil-d4 (hydrochloride) An internal standard for the quantification of donepezil
  30. GC47263 Donecopride (fumarate hydrate) A 5-HT4 receptor partial agonist and AChE inhibitor
  31. GC47186 Deoxy Donepezil (hydrochloride) A potential impurity found in bulk preparations of donepezil
  32. GC46997 C22 Galactosylceramide (d18:1/22:0) A sphingolipid
  33. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt) A 42-amino acid protein fragment of amyloid-β
  34. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors
  35. GC46451 16F16 A PDI inhibitor
  36. GC46208 Propentofylline A xanthine derivative and neuroprotective agent
  37. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
  38. GC45831 SRI-011381 A TGF-β signaling activator
  39. GC45765 Deferiprone-d3 An internal standard for the quantification of deferiprone
  40. GC45378 Alaproclate (hydrochloride) An SSRI
  41. GC45137 Valproic Acid Acyl-D-Glucuronide A metabolite of valproic acid
  42. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) A fluorescently labeled amyloid-β peptide
  43. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
  44. GC44674 Pramlintide (acetate hydrate) An amylin analog
  45. GC44416 N-methyl Mesoporphyrin IX A ferrochelatase inhibitor and turn-on biosensor for DNA
  46. GC44399 NIAD-4 A fluorescent probe for Aβ
  47. GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
  48. GC43708 Fulvic Acid A fungal metabolite
  49. GC43700 FSB A fluorescent probe
  50. GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
  51. GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β

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