Alzheimer(阿尔茨海默病)

Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more
- Cat.No. 产品名称 Information
-
GC52496
Sulfatide (bovine) (sodium salt)
A mixture of isolated bovine sulfatides
-
GC52214
Nicotinamide riboside-d4 (triflate)
An internal standard for the quantification of nicotinamide riboside
-
GC52172
5-hydroxy Indole-3-acetic Acid-d6
An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
-
GC52078
Galantamine (hydrobromide)
An alkaloid with AChE inhibitory and nAChR potentiating activities
-
GC52047
Fustin
A flavanone with diverse biological activities
-
GC52027
Isolariciresinol
A lignan with diverse biological activities
-
GC49913
Davunetide (acetate)
A neuroprotective ADNP-derived peptide
-
GC49815
Oleuropein aglycone
A polyphenol with diverse biological activities
-
GC49557
Cu-GTSM
A copper-containing compound with diverse biological activities
-
GC49493
IRL 1620 (trifluoroacetate salt)
A peptide ETB receptor agonist
-
GC49461
L-Serine-d7
An internal standard for the quantification of L-serine
-
GC49436
L-3-n-Butylphthalide
A phthalide with antiplatelet and neuroprotective activities
-
GC49417
L-Serine-13C3
An internal standard for the quantification of L-serine
-
GC49306
Isopimaric Acid
A diterpenoid resin acid
-
GC49273
Glycerophosphorylethanolamine (sodium salt)
An active metabolite of phosphatidylethanolamine
-
GC49192
Piracetam-d6
An internal standard for the quantification of piracetam
-
GC49108
Racecadotril-d5
An internal standard for the quantification of racecadotril
-
GC49090
Nilvadipine-d4
An internal standard for the quantification of nilvadipine
-
GC49024
Palmitic Acid MaxSpec® Standard
A long-chain saturated fatty acid
-
GC49023
Palmitic Acid-d9 MaxSpec® Standard
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
-
GC48969
Withanone
A phytochemical with diverse biological activities
-
GC48362
PMX-205 (trifluoroacetate salt)
A potent antagonist of C5aR
-
GC48028
Rasagiline-13C3 (mesylate)
An internal standard for the quantification of rasagiline
-
GC47955
Phloroglucinol
A phenol with diverse biological activities
-
GC47746
NAP 226-90
A metabolite of rivastigmine
-
GC47563
L-Glutamic Acid (ammonium salt)
An excitatory neurotransmitter
-
GC47389
Galantamine-d3 (hydrobromide)
An internal standard for the quantification of galantamine
-
GC47264
Donepezil-d4 (hydrochloride)
An internal standard for the quantification of donepezil
-
GC47263
Donecopride (fumarate hydrate)
A 5-HT4 receptor partial agonist and AChE inhibitor
-
GC47186
Deoxy Donepezil (hydrochloride)
A potential impurity found in bulk preparations of donepezil
-
GC46997
C22 Galactosylceramide (d18:1/22:0)
A sphingolipid
-
GC46851
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
A 42-amino acid protein fragment of amyloid-β
-
GC46720
6,9-Dichloro-1,2,3,4-tetrahydroacridine
A synthetic intermediate in the synthesis of AChE inhibitors
-
GC46451
16F16
A PDI inhibitor
-
GC46208
Propentofylline
A xanthine derivative and neuroprotective agent
-
GC45917
Leucettine L41
An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
-
GC45831
SRI-011381
A TGF-β signaling activator
-
GC45765
Deferiprone-d3
An internal standard for the quantification of deferiprone
-
GC45378
Alaproclate (hydrochloride)
An SSRI
-
GC45137
Valproic Acid Acyl-D-Glucuronide
A metabolite of valproic acid
-
GC44987
TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
A fluorescently labeled amyloid-β peptide
-
GC44968
Sulfatides (bovine) (sodium salt)
Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
-
GC44674
Pramlintide (acetate hydrate)
An amylin analog
-
GC44416
N-methyl Mesoporphyrin IX
A ferrochelatase inhibitor and turn-on biosensor for DNA
-
GC44399
NIAD-4
A fluorescent probe for Aβ
-
GC44225
ML-345
An inhibitor of the insulin-degrading enzyme
-
GC43708
Fulvic Acid
A fungal metabolite
-
GC43700
FSB
A fluorescent probe
-
GC43494
DL-threo-PDMP (hydrochloride)
An inhibitor of sphingolipid biosynthesis
-
GC43322
CRANAD 28
A fluorescent affinity probe for amyloid-β