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Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

  1. Cat.No. 产品名称 Information
  2. GC52172 5-hydroxy Indole-3-acetic Acid-d6 An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
  3. GC52078 Galantamine (hydrobromide) An alkaloid with AChE inhibitory and nAChR potentiating activities
  4. GC52047 Fustin Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 是一种有效的淀粉样蛋白 β (Aβ) 抑制剂。
  5. GC52027 Isolariciresinol Isolaririresinol ((+)-Cyclolariciresinol) 可用于风湿病的研究。
  6. GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide
  7. GC49815 Oleuropein aglycone A polyphenol with diverse biological activities
  8. GC49557 Cu-GTSM A copper-containing compound with diverse biological activities
  9. GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist
  10. GC49461 L-Serine-d7 An internal standard for the quantification of L-serine
  11. GC49436 L-3-n-Butylphthalide A phthalide with antiplatelet and neuroprotective activities
  12. GC49417 L-Serine-13C3 L-Serine-13C3 ((-)-Serine-13C3) 是 13C 标记的 L-丝氨酸。 L-丝氨酸((-)-丝氨酸;(S)-丝氨酸),一种所谓的非必需氨基酸,在细胞增殖中起核心作用。
  13. GC49306 Isopimaric Acid 异海松酸是大电导钙激活 K+ (BK) 通道的有效开启剂。
  14. GC49273 Glycerophosphorylethanolamine (sodium salt) An active metabolite of phosphatidylethanolamine
  15. GC49192 Piracetam-d6 An internal standard for the quantification of piracetam
  16. GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
  17. GC49090 Nilvadipine-d4 An internal standard for the quantification of nilvadipine
  18. GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
  19. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
  20. GC48969 Withanone Withanone 是来自 Withania somnifera 根的活性成分,在缓解认知功能障碍方面具有多功能神经保护作用。
  21. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
  22. GC48028 Rasagiline-13C3 (mesylate) An internal standard for the quantification of rasagiline
  23. GC47955 Phloroglucinol A phenol with diverse biological activities
  24. GC47746 NAP 226-90 A metabolite of rivastigmine
  25. GC47563 L-Glutamic Acid (ammonium salt) An excitatory neurotransmitter
  26. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
  27. GC47264 Donepezil-d4 (hydrochloride) An internal standard for the quantification of donepezil
  28. GC47263 Donecopride (fumarate hydrate) A 5-HT4 receptor partial agonist and AChE inhibitor
  29. GC47186 Deoxy Donepezil (hydrochloride) A potential impurity found in bulk preparations of donepezil
  30. GC46997 C22 Galactosylceramide (d18:1/22:0) A sphingolipid
  31. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt) A 42-amino acid protein fragment of amyloid-β
  32. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors
  33. GC46451 16F16 A PDI inhibitor
  34. GC46208 Propentofylline Propentofylline 是一种黄嘌呤衍生物,可抑制腺苷摄取并阻断磷酸二酯酶活性。
  35. GC45917 Leucettine L41 Leucettine L41 是双特异性酪氨酸磷酸化调节激酶 1A (DYRK1A)、DYRK2、CDC 样激酶 1 (CLK1) 和 CLK3 的有效抑制剂(IC50s = 0.04、0.035、0.015 和 4.5 μM,分别)[1 ]。
  36. GC45831 SRI-011381 SRI-011381 是一种口服活性 TGF-β 信号激动剂,具有神经保护作用。
  37. GC45765 Deferiprone-d3 An internal standard for the quantification of deferiprone
  38. GC45378 Alaproclate (hydrochloride)  
  39. GC45137 Valproic Acid Acyl-D-Glucuronide Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.
  40. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide.
  41. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
  42. GC44674 Pramlintide (acetate hydrate) Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29.
  43. GC44416 N-methyl Mesoporphyrin IX N-甲基中卟啉 IX (NMM) 是一种广泛使用的 G-四链体 DNA 特异性荧光结合剂,是监测 Aβ 纤颤的有效探针。
  44. GC44399 NIAD-4 NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM).
  45. GC44225 ML-345 ML-345 是一种有效的选择性胰岛素降解酶 (IDE) 小分子抑制剂,IC50 值为 188 nM。
  46. GC43708 Fulvic Acid 黄腐酸是一种天然产物,来源于土壤中微生物产生的腐殖质。
  47. GC43700 FSB FSB 是一种荧光染料,可用于检测丝状 tau 并以高灵敏度和特异性标记人类淀粉样蛋白病变(激发:390 nm,发射:520 nm)。
  48. GC43494 DL-threo-PDMP (hydrochloride) DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo (1R,2R) and L-threo (1S,2S) PDMP.
  49. GC43322 CRANAD 28 CRANAD 28 是一种强大的荧光化合物,用于显示β淀粉样蛋白斑块。
  50. GC43274 Citromycetin Citromycetin 是一种来自澳大利亚海洋和陆地青霉属的芳香族聚酮化合物。
  51. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand.

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