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Home >> Signaling Pathways >> Neuroscience >> Alzheimer

Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC91977 TrkB Agonist Prodrug R13

    TrkB-IN-1; Tropomyosin-related Kinase B Agonist Prodrug R13; Tropomyosin-related Kinase B Inhibitor 1

     TrkB Agonist Prodrug R13（R13）是原肌球蛋白相关激酶B（TrkB）激活剂7,8-二羟基黄酮的前药形式。
  3. GC91899 Carmustine-d8

    BCNU-d8; bis-Chloroethylnitrosourea-d8

     Carmustine-d8旨在用作气相色谱或液相色谱-质谱定量卡莫司汀的内标。
  4. GC91621 WLB-89462 WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).
  5. GC72054 Obovatol Obovatol是一种从厚朴叶中分离出来的联苯醚木脂素。
  6. GC26199 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

    1-十七碳酰-甘油-3-磷酰胆碱
  7. GC91070 p-methyl-N-salicyloyl Tryptamine

    LZWL02003, para-methyl-N-salicyloyl Tryptamine

    一种神经保护剂
  8. GC52496 Sulfatide (bovine) (sodium salt)

    Galactosylceramide I3-sulfate, Ganglioside SM4, I3SO3-GalCer, SM4, Sulfated Galactocerebroside, 3-O-Sulfogalactosylceramide

     A mixture of isolated bovine sulfatides
  9. GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
  10. GC52172 5-hydroxy Indole-3-acetic Acid-d6

    5-HIAA-d6, 5-Hydroxyindoleacetic Acid-d6, 5-hydroxy IAA-d6

     An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
  11. GC20007 Ginsenoside CK

    20(S)-人参皂苷 C-K; Compound K

    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.
  12. GC65195 2-O-Acetyl-20-hydroxyecdysone

    2-乙酰基Β-蜕皮甾酮,20-Hydroxyeedysone 2-acetate

     An ecdysone steroid hormone
  13. GC52078 Galantamine (hydrobromide)

    氢溴酸加兰他敏

    An alkaloid with AChE inhibitory and nAChR potentiating activities
  14. GC52047 Fustin

    黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone

     A flavanone with diverse biological activities
  15. GC52027 Isolariciresinol

    异落叶松脂素,(+)-Cyclolariciresinol

     A lignan with diverse biological activities
  16. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

     A neuroprotective ADNP-derived peptide
  17. GC49815 Oleuropein aglycone

    3,4-DHPEA-EA

     A polyphenol with diverse biological activities
  18. GC49557 Cu-GTSM

    CuII(gtsm), copper-GTSM

     A copper-containing compound with diverse biological activities
  19. GC49493 IRL 1620 (trifluoroacetate salt)

    PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)

     A peptide ETB receptor agonist
  20. GC49461 L-Serine-d7

    L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7

     An internal standard for the quantification of L-serine
  21. GC49436 L-3-n-Butylphthalide

    (-)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(-)-3-Butylphthalide, L-NBP

     A phthalide with antiplatelet and neuroprotective activities
  22. GC49417 L-Serine-13C3

    L-丝氨酸-13C3,(-)-Serine-13C3; (S)-Serine-13C3

     An internal standard for the quantification of L-serine
  23. GC49306 Isopimaric Acid

    异海松酸

     A diterpenoid resin acid
  24. GC49273 Glycerophosphorylethanolamine (sodium salt)

    Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine

     An active metabolite of phosphatidylethanolamine
  25. GC49192 Piracetam-d6

    UCB-6215-d6

     An internal standard for the quantification of piracetam
  26. GC49108 Racecadotril-d5

    消旋卡多曲杂质,Acetorphan-d5

     An internal standard for the quantification of racecadotril
  27. GC49090 Nilvadipine-d4

    (±)-Nilvadipine-d4

     An internal standard for the quantification of nilvadipine
  28. GC49024 Palmitic Acid MaxSpec® Standard

    棕榈酸

     A long-chain saturated fatty acid
  29. GC49023 Palmitic Acid-d9 MaxSpec® Standard

    棕榈酸-13,13,14,14,15,15,16,16,16-D9

     A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
  30. GC48969 Withanone

    NSC 179884

     A phytochemical with diverse biological activities
  31. GC19799 Selegiline hydrochloride

    盐酸司来吉兰; Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride

     A selective inhibitor of MAO-B
  32. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
  33. GC48083 sn-Glycerol-3-phosphate (cyclohexyl ammonium salt hydrate)

    G3P

     A neuropeptide with diverse biological activities
  34. GC48028 Rasagiline-13C3 (mesylate)

    甲磺酸雷沙吉兰-13C3

     An internal standard for the quantification of rasagiline
  35. GC47955 Phloroglucinol

    间苯三酚

     A phenol with diverse biological activities
  36. GC47746 NAP 226-90

    3-(1-(S)-(N,N-二甲基氨基)乙基)苯酚

     A metabolite of rivastigmine
  37. GC47563 L-Glutamic Acid (ammonium salt)

    谷氨酸一铵

     An excitatory neurotransmitter
  38. GC47437 Humanin (human) (trifluoroacetate salt)

    HN

     A neuropeptide with diverse biological activities
  39. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
  40. GC47264 Donepezil-d4 (hydrochloride)

    多奈哌齐-D4,E2020-d4

     An internal standard for the quantification of donepezil
  41. GC47263 Donecopride (fumarate hydrate)

    MR31147

     A 5-HT4 receptor partial agonist and AChE inhibitor
  42. GC47196 Desloratadine-d4

    Sch34117-d4

     An internal standard for the quantification of desloratadine
  43. GC47186 Deoxy Donepezil (hydrochloride)

    1-苄基-4-((5,6-二甲氧基-2,3-二氢-1H-茚-2-基)甲基)哌啶盐酸盐

     A potential impurity found in bulk preparations of donepezil
  44. GC46998 C22 Galactosylceramide-d4 (d18:1/22:0-d4)

    Galactosylceramide-d4 (d18:1/22:0-d4), N-Docosanoyl-β-D-Galactosylceramide-d4, GalCer(d18:1/22:0-d4)

     A neuropeptide with diverse biological activities
  45. GC46997 C22 Galactosylceramide (d18:1/22:0)

    N-Docosanoyl-β-D-Galactosylceramide, Galactosylceramide (d18:1/22:0), GalCer(d18:1/22:0)

     A sphingolipid
  46. GC46992 C18 Ganglioside GM1-d3 (d18:1/18:0-d3) (ammonium salt)

    N-omega-CD3-Octadecanoyl monosialoganglioside GM1-d3, N-CD3-Stearoyl-GM, C18 GM1-d3, GM1 (18:1/18:0-d3), GM1 (d18:1/C18:0)-d3, Monosialoganglioside GM1-d3, N-Stearoyl Monosialoganglioside GM1-d3

     A neuropeptide with diverse biological activities
  47. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Aβ (1-42), Aβ42

     A 42-amino acid protein fragment of amyloid-β
  48. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine

    NSC 1227

     A synthetic intermediate in the synthesis of AChE inhibitors
  49. GC46451 16F16 A PDI inhibitor
  50. GC39419 PBD-150 A glutaminyl cyclase inhibitor
  51. GC46208 Propentofylline

    普罗潘非林,HWA 285

     A xanthine derivative and neuroprotective agent

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