Alzheimer(阿尔茨海默病)
Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more
Products for Alzheimer
- Cat.No. 产品名称 Information
- GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides
- GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
- GC52172 5-hydroxy Indole-3-acetic Acid-d6 An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
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GC52078
Galantamine (hydrobromide)
An alkaloid with AChE inhibitory and nAChR potentiating activities
- GC52047 Fustin A flavanone with diverse biological activities
- GC52027 Isolariciresinol A lignan with diverse biological activities
- GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide
- GC49815 Oleuropein aglycone A polyphenol with diverse biological activities
- GC49557 Cu-GTSM A copper-containing compound with diverse biological activities
- GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist
- GC49461 L-Serine-d7 An internal standard for the quantification of L-serine
- GC49436 L-3-n-Butylphthalide A phthalide with antiplatelet and neuroprotective activities
- GC49417 L-Serine-13C3 An internal standard for the quantification of L-serine
- GC49306 Isopimaric Acid A diterpenoid resin acid
- GC49273 Glycerophosphorylethanolamine (sodium salt) An active metabolite of phosphatidylethanolamine
- GC49192 Piracetam-d6 An internal standard for the quantification of piracetam
- GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
- GC49090 Nilvadipine-d4 An internal standard for the quantification of nilvadipine
- GC49024 Palmitic Acid MaxSpec® Standard A long-chain saturated fatty acid
- GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
- GC48969 Withanone A phytochemical with diverse biological activities
- GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
- GC48028 Rasagiline-13C3 (mesylate) An internal standard for the quantification of rasagiline
- GC47955 Phloroglucinol A phenol with diverse biological activities
- GC47746 NAP 226-90 A metabolite of rivastigmine
- GC47563 L-Glutamic Acid (ammonium salt) An excitatory neurotransmitter
- GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
- GC47264 Donepezil-d4 (hydrochloride) An internal standard for the quantification of donepezil
- GC47263 Donecopride (fumarate hydrate) A 5-HT4 receptor partial agonist and AChE inhibitor
- GC47186 Deoxy Donepezil (hydrochloride) A potential impurity found in bulk preparations of donepezil
- GC46997 C22 Galactosylceramide (d18:1/22:0) A sphingolipid
- GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt) A 42-amino acid protein fragment of amyloid-β
- GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors
- GC46451 16F16 A PDI inhibitor
- GC46208 Propentofylline A xanthine derivative and neuroprotective agent
- GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
- GC45831 SRI-011381 A TGF-β signaling activator
- GC45765 Deferiprone-d3 An internal standard for the quantification of deferiprone
- GC45378 Alaproclate (hydrochloride) An SSRI
- GC45137 Valproic Acid Acyl-D-Glucuronide A metabolite of valproic acid
- GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) A fluorescently labeled amyloid-β peptide
- GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
- GC44674 Pramlintide (acetate hydrate) An amylin analog
- GC44416 N-methyl Mesoporphyrin IX A ferrochelatase inhibitor and turn-on biosensor for DNA
- GC44399 NIAD-4 A fluorescent probe for Aβ
- GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
- GC43708 Fulvic Acid A fungal metabolite
- GC43700 FSB A fluorescent probe
- GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
- GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β