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(Synonyms: L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7) 目录号 : GC49461

An internal standard for the quantification of L-serine

L-Serine-d7 Chemical Structure

Cas No.:935275-35-7

规格 价格 库存 购买数量
5 mg
¥682.00
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10 mg
¥1,222.00
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25 mg
¥2,681.00
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50 mg
¥4,029.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

L-Serine-d7 is intended for use as an internal standard for the quantification of L-serine by GC- or LC-MS. L-Serine is a non-essential amino acid.1 It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation in PGDH.1,2 Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.

1.Holm, L.J., and Buschard, K.L-serine: A neglected amino acid with a potential therapeutic role in diabetesAPMIS127(10)655-659(2019) 2.Metcalf, J.S., Dunlop, R.A., Powell, J.T., et al.L-serine: A naturally-occurring amino acid with therapeutic potentialNeurotox. Res.33(1)213-221(2018)

Chemical Properties

Cas No. 935275-35-7 SDF Download SDF
别名 L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7
Canonical SMILES [2H]OC([C@](N([2H])[2H])([2H])C([2H])([2H])O[2H])=O
分子式 C3D7NO3 分子量 112.1
溶解度 Water: soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 8.9206 mL 44.603 mL 89.2061 mL
5 mM 1.7841 mL 8.9206 mL 17.8412 mL
10 mM 0.8921 mL 4.4603 mL 8.9206 mL
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