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Galantamine (hydrobromide) Sale

(Synonyms: 氢溴酸加兰他敏) 目录号 : GC52078

An alkaloid with AChE inhibitory and nAChR potentiating activities

Galantamine (hydrobromide) Chemical Structure

Cas No.:69353-21-5

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50 mg
¥936.00
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100 mg
¥1,491.00
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250 mg
¥3,505.00
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产品描述

Galantamine is an alkaloid that has been found in Galanthus and has acetylcholinesterase (AChE) inhibitory and nicotinic acetylcholine receptor (nAChR) potentiating activities.1,2,3 It selectively inhibits AChE over butyrylcholinesterase (BChE; IC50s = 636 and 8,404 nM, respectively).2 Galantamine (0.5 &#181M) potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs. In vivo, galantamine (1.3 mg/kg per day) decreases escape latency and path length in the Morris water maze in the APP23 transgenic mouse model of Alzheimer’s disease.4 Formulations containing galantamine have been used in the treatment of Alzheimer’s disease.

1.Harvey, A.L.The pharmacology of galanthamine and its analoguesPharmacol. Ther.68(1)113-128(1995) 2.Rook, Y., Schmidtke, K.U., Gaube, F., et al.Bivalent β-carbolines as potential multitarget anti-Alzheimer agentsJ. Med. Chem.53(9)3611-3617(2010) 3.Samochocki, M., Zerlin, M., Jostock, R., et al.Galantamine is an allosterically potentiating ligand of the human α4/β2 nAChRActa Neurol. Scand. Suppl.17668-73(2000) 4.Van Dam, D., and De Deyn, P.P.Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 modelEur. Neuropsychopharmacol.16(1)59-69(2006)

Chemical Properties

Cas No. 69353-21-5 SDF Download SDF
别名 氢溴酸加兰他敏
Canonical SMILES COC1=C2C3=C(C=C1)CN(C)CC[C@@]34[C@@](C[C@H](C=C4)O)([H])O2.Br
分子式 C17H21NO3 • HBr 分子量 368.3
溶解度 DMF: insol,DMSO: insol,Ethanol: insol,PBS (pH 7.2): 2 mg/ml 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 2.7152 mL 13.5759 mL 27.1518 mL
5 mM 0.543 mL 2.7152 mL 5.4304 mL
10 mM 0.2715 mL 1.3576 mL 2.7152 mL
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