Home>>Signaling Pathways>> Neuroscience>> Alzheimer>>Nicotinamide riboside-d4 (triflate)

Nicotinamide riboside-d4 (triflate) Sale

目录号 : GC52214

An internal standard for the quantification of nicotinamide riboside

Nicotinamide riboside-d4 (triflate) Chemical Structure

规格 价格 库存 购买数量
1 mg
¥1,330.00
现货
5 mg
¥5,992.00
现货
10 mg
¥10,640.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

Nicotinamide riboside-d4 is intended for use as an internal standard for the quantification of nicotinamide riboside by GC- or LC-MS. Nicotinamide riboside is a riboside form of nicotinamide that is found in trace amounts in yeast-containing and milk-derived products.1 It is a precursor of NAD+ and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells when used at concentrations ranging from 1-1,000 μM.2 It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and SIRT3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer's disease.3

1.Chi, Y., and Sauve, A.A.Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotectionCurr. Opin. Clin. Nutr. Metab. Care15(6)657-661(2013) 2.CantÓ, C., Houtkooper, R.H., Pirinen, E., et al.The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesityCell Metab.15(6)838-847(2012) 3.Gong, B., Pan, Y., Vempati, P., et al.Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse modelsNeurobiol. Aging34(6)1581-1588(2013)

Chemical Properties

Cas No. SDF Download SDF
Canonical SMILES O[C@H]1[C@@]([N+]2=C([2H])C([2H])=C([2H])C(C(N)=O)=C2[2H])([H])O[C@@H]([C@H]1O)CO.FC(F)(S(=O)([O-])=O)F
分子式 C11H11D4N2O5 ? CF3SO3 分子量 408.3
溶解度 Methanol: soluble,Water: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.4492 mL 12.2459 mL 24.4918 mL
5 mM 0.4898 mL 2.4492 mL 4.8984 mL
10 mM 0.2449 mL 1.2246 mL 2.4492 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置