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Piracetam-d6 Sale

(Synonyms: UCB-6215-d6) 目录号 : GC49192

An internal standard for the quantification of piracetam

Piracetam-d6 Chemical Structure

规格 价格 库存 购买数量
500 µg
¥1,696.00
现货
1 mg
¥3,221.00
现货
5 mg
¥15,264.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Piracetam-d6 is intended for use as an internal standard for the quantification of piracetam by GC- or LC-MS. Piracetam is a nootropic cyclic GABA derivative.1 It is a positive allosteric modulator of AMPA receptors and enhances binding of the NMDA antagonist MK-801 to rat forebrain membranes.2,3 Piracetam (1 mM) protects against amyloid-β-induced decreases in the mitochondrial membrane potential, as well as decreases in neurite outgrowth in the presence of NGF, in PC12 rat adrenal medulla cells.4 It prevents scopolamine-induced amnesia in a passive avoidance test in mice when administered at a dose of 30 mg/kg.5 Formulations containing piracetam have been used in the treatment of myoclonus.

1.Winnicka, K., Tomasiak, M., and Bielawska, A.Piracetam - An old drug with novel properties•Acta Pol. Pharm.62(5)405-409(2005) 2.Copani, A., Genassani, A.A., Aleppo, G., et al.Nootropic drugs positively modulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal culturesJ. Neurochem.58(4)1199-1204(1992) 3.Hamelin, S.M., and Lehmann, J.C.Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 bindingEur. J. Pharmacol.281(3)R11-R13(1995) 4.Kurz, C., Ungerer, I., Lipka, U., et al.The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by β-amyloid peptideBr. J. Pharmacol.160(2)246-257(2010) 5.Ghelardini, C., Galeotti, N., Gualtieri, F., et al.The novel nootropic compound DM232 (unifiram) ameliorates memory impairment in mice and ratsDrug Develop. Res.56(1)23-32(2002)

Chemical Properties

Cas No. N/A SDF
别名 UCB-6215-d6
Canonical SMILES NC(CN1C(C([2H])([2H])C([2H])([2H])C1([2H])[2H])=O)=O
分子式 C6H4D6N2O2 分子量 148.2
溶解度 DMSO: soluble,Methanol: soluble,Water: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 6.7476 mL 33.7382 mL 67.4764 mL
5 mM 1.3495 mL 6.7476 mL 13.4953 mL
10 mM 0.6748 mL 3.3738 mL 6.7476 mL
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