Mitochondrial Metabolism(线粒体代谢)
Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.
Products for Mitochondrial Metabolism
- Cat.No. 产品名称 Information
- GC40801 (±)9(10)-DiHOME A diol form of (±)9(10)-EpOME
- GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。此外,它还能抑制谷氨酸脱氢酶1/2 (GDH1/2, GLUD1/2)的活性。.
- GC41721 (R)-α-Lipoic Acid A cyclic disulfide antioxidant
- GC18596 (±)-2-propyl-4-Pentenoic Acid A metabolite of valproic acid
- GC19528 1,4-Benzoquinone A toxic metabolite of benzene
- GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade) A formyl donor and cofactor
- GC46451 16F16 A PDI inhibitor
- GC42193 2-Thenoyltrifluoroacetone An inhibitor of respiration
- GC49849 3-Aminosalicylic Acid A salicylic acid derivative
- GC42351 4-carboxy TEMPO A spin label
- GC49722 4-CF3-TPP-DC An inert mitochondriotropic carrier
- GC41310 5-Octyl-α-ketoglutarate A cell-permeable form of α-ketoglutarate
- GC46779 Acequinocyl A naphthoquinone acaricide
- GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate) A precursor to HMG-CoA
- GC46789 Acetyl-L-carnitine-d3 (chloride) An internal standard for the quantification of L-acetylcarnitine
- GC19021 Adjudin A derivative of lonidamine
- GC42742 ADT-OH A synthetic H2S donor used in making chimeras
- GC46812 Aflatoxin G1-13C17 An internal standard for the quantification of aflatoxin G1
- GC35262 Afzelin A polyphenolic glycoside flavone with diverse biological activities
- GC63642 Agaric acid Agaric acid (Agaricinic Acid) 来自真菌部落的 Polyporus officinalis 和 Polyporus igniarius。Agaric acid 通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。Agaric acid 可促进积累的 Ca2+ 流出,跨膜电位的破坏和线粒体肿胀。Agaric acid 用于调节脂类代谢。
- GC18437 Alternariol monomethyl ether A mycotoxin
- GC18274 Amiprofos-methyl An herbicide
- GC42818 Antimycin A1 An active component of the antimycin A antibiotic complex
- GC18621 Antimycin A2 An active component of the antimycin A antibiotic complex
- GC42820 Antimycin A4 An active component of the antimycin A antibiotic complex
- GC42821 AP219 A control compound for AP39
- GC42823 AP39 A mitochondrial H2S donor
- GC42846 Arachidonoyl-L-carnitine (chloride) A C20:4 acylcarnitine
- GC46883 AS-2077715 An inhibitor of fungal complex III
- GC31432 Asp-AMS Asp-AMS是天冬氨酸腺苷酸的一个类似物,是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂,也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。
- GC42874 Aureothin A polyketide antibiotic that inhibits oxidoreductase
- GC40677 Avenaciolide A fungal metabolite
- GC18580 B355252 A neuroprotective agent
- GC49901 BAY-179 A mitochondrial complex I inhibitor
- GC49403 Benzarone An active metabolite of benzbromarone
- GC49318 Benzovindiflupyr A fungicide
- GC41252 BI-6C9 An inhibitor of tBid-mediated apoptosis
- GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt) A Bim-derived peptide
- GC18408 BML-278 An activator of SIRT1, SIRT2, and SIRT3
- GC46943 Boscalid A broad-spectrum carboxamide fungicide
- GC42978 Bromamphenicol A dibrominated derivative of chloramphenicol
- GC43030 C16 dihydro Ceramide (d18:0/16:0) A bioactive sphingolipid
- GC48425 C18 D-threo Ceramide (d18:1/18:0) A synthetic ceramide
- GC49806 C18 Ganglioside GD3-d3 (ammonium salt) An internal standard for the quantification of ganglioside GD3
- GC43050 C18 L-erythro Ceramide (d18:1/18:0) A naturally occurring ceramide
- GC43051 C18 L-threo Ceramide (d18:1/18:0) A synthetic ceramide
- GC43052 C18 Phytoceramide (t18:0/18:0) A bioactive sphingolipid
- GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3) An internal standard for the quantification of C18 phytoceramide
- GC43069 C22 Ceramide (d18:1/22:0) A bioactive sphingolipid
- GC43141 Carboxyatractyloside (potassium salt) An inhibitor of ADP/ATP translocases