Amyloid β(β淀粉样蛋白)
Amyloid β denotes peptides of 36–43 amino acids result from the APP (amyloid precursor protein) and are involved in Alzheimer's disease as the main component of the amyloid plaques.
- Cat.No. 产品名称 Information
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GC66416
β-Amyloid (22-35) (TFA)
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GC66406
Aducanumab
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GC66346
β-Amyloid (42-1), human TFA
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GC66089
β-Amyloid (1-40) (TFA)
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GC65582
Tramiprosate-d6
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GC65281
Aleplasinin
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GC64935
Thiethylperazine dimaleate
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GC64934
Thiethylperazine
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GC63502
Aβ/tau aggregation-IN-1
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GC63274
β-Amyloid (1-42), (rat/mouse) (TFA)
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GC63273
β-Amyloid (1-14),mouse,rat
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GC63230
TML-6
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GC62966
Ezeprogind disulfate
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GC62834
ALZ-801
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GC62702
RAGE antagonist peptide TFA
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GC61887
Cl-NQTrp
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GC61476
Fmoc-Ala-Glu-Asn-Lys-NH2
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GC50733
Davunetide
A neuroprotective ADNP-derived peptide
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GC39254
Anatabine dicitrate
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GC38628
Licochalcone B
Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
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GA20736
Amyloid β-Protein (1-43)
淀粉样蛋白 β-Protein (1-43) 比久负盛名的 Aβ1-42 更容易聚集并具有更高的毒性。
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GA20735
Amyloid β-Protein (1-42)
For a detailed description of Aβ 1-42, please see product H-1368.
For the preparation of Aβ for experimental use, Fezoui et al. (2000) found that solvation of synthetic peptide with sodium hydroxide (Aβ.NaOH) followed by lyophilization, produced stocks with superior solubility and fibrillogenesis characteristics. Solubilization of the pretreated material with neutral buffers resulted in a pH transition from ≈10.5 to neutral, avoiding the isoelectric point of Aβ (pI≈5.5), at which Aβ precipitation and aggregation propensity are maximal.
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GA20734
Amyloid β-Protein (1-42)
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GA20733
Amyloid β-Protein (1-42)
与内盐相比,Aβ42 的盐酸盐在 pH 7.4 时更容易聚集。
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GA20732
Amyloid β-Protein (1-42)
Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide.
The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy.
For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.
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GA20730
Amyloid β-Protein (1-42) (HFIP-treated)
H-7442 是通过将淀粉样蛋白 β-蛋白质 (1-42) (H-1368) 溶解在 HFIP 中,等分并去除溶剂而获得的,如文献中所述。
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GC37997
β-Amyloid 4-10
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GC37996
β-Amyloid 35-42
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GC37995
β-Amyloid 33-40
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GC37994
β-Amyloid 22-40
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GC37993
β-Amyloid 1-9
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GC37992
β-Amyloid 18-28
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GC37991
β-Amyloid 15-21
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GC37988
β-Amyloid 12-20
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GC37987
β-Amyloid 1-20
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GC37986
β-Amyloid 1-17
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GC37985
β-Amyloid 11-22
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GC37984
β-Amyloid (1-42), rat
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GC37639
Silybin B
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GC37624
Semilicoisoflavone B
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GC37610
Scyllo-Inositol
A stereoisomer of inositol
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GC36954
PQM130
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GC36247
Hoechst 34580 tetrahydrochloride
Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. Hoechst 34580 is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.
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GC36156
Glutaminyl Cyclase Inhibitor 3
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GC36110
gamma-Secretase Modulators
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GC36076
Frentizole
Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
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GC35720
Colivelin TFA
A potent STAT3 activator and neuroprotective agent
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GC35334
Amyloid β Peptide (42-1)(human)
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GC44856
Rutin (hydrate)
A flavonoid glycoside with diverse biological activities
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GC34242
β-Amyloid (1-42), rat TFA