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Home >> Signaling Pathways >> Neuroscience >> Serotonin Transporter

Serotonin Transporter(血清素转运蛋白)

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products for  Serotonin Transporter

  1. Cat.No. 产品名称 Information
  2. GC70178 ZZL-7 ZZL-7 是一种速效抗抑郁剂。ZZL-7 通过破坏中缝背核 (DRN) 中的血清素转运体 (SERT) 和神经元一氧化氮合酶 (nNOS) 之间的相互作用起作用。ZZL-7 可以轻松穿过血脑屏障，并可用于重度抑郁症 (MDD) 的研究。
  3. GC69880 SERT-IN-2 SERT-IN-2 是一种强效 SERT 抑制剂 (IC50=0.58 nM)，具有抗抑郁活性。SERT-IN-2 的生物利用度好，在大鼠中 F(%) 为 83.28%。SERT-IN-2 能够透过血脑屏障。
  4. GC25708 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
  5. GC65209 Imipramine-d4 hydrochloride Imipramine-d4 hydrochloride 是 Imipramine hydrochloride 的氘代物。Imipramine hydrochloride 抑制血清素转运蛋白(serotonin)，IC50 值为 32 nM。Imipramine hydrochloride 可阻止胰酶的易位，抑制 MV 和外泌体的分泌。
  6. GC65014 DSP-1053 DSP-1053 是一种苄基哌啶衍生物，一种有效的血清素转运蛋白 (SERT) 抑制剂，Ki 值为 1.02 nM。DSP-1053 显示部分 5-HT1A 受体激动活性，Ki 值为 5.05 nM。DSP-1053 具有抗抑郁活性。
  7. GC48255 Vortioxetine-d8 An internal standard for the quantification of vortioxetine
  8. GC47277 Duloxetine-d3 (hydrochloride) An internal standard for the quantification of duloxetine
  9. GC47101 Clomipramine-d3 (hydrochloride) An Analytical Reference Standard
  10. GC60740 Dapoxetine-D7 hydrochloride Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。
  11. GC60424 (S)-Venlafaxine (S)-Venlafaxine是Venlafaxine的S构型化合物。Venlafaxine是口服有效的5-羟色胺(5-HT)/去甲肾上腺素(NE)重摄取的双重抑制剂。Venlafaxine具有抗抑郁作用。
  12. GC60394 (±)-Duloxetine hydrochloride (±)-Duloxetine((Rac)-Duloxetine)hydrochloride是Duloxetinehydrochloride的外消旋体。Duloxetinehydrochloride是一种5-羟色胺去甲肾上腺素再摄取抑制剂，可用于糖尿病性神经痛和纤维肌痛以及抑郁症的研究。
  13. GC18497 Dapoxetine hydrochloride An Analytical Reference Standard
  14. GC37906 Vilazodone D8 An internal standard for the quantification of vilazodone
  15. GC35444 Azaphen dihydrochloride monohydrate Pipofezine(Azafen，Azaphen)是5-羟色胺重吸收抑制剂。
  16. GC35443 Azaphen Pipofezine(Azafen,Azaphen)是5-羟色胺重吸收抑制剂。
  17. GC44057 Levomilnacipran (hydrochloride) A serotonin and norepinephrine reuptake inhibitor
  18. GC34575 Eplivanserin mixture Eplivanserinmixture是一种选择性的血清素再摄取抑制剂，是5-HT2A受体的拮抗剂。化合物信息来自专利WO2005/002578A1。
  19. GC34559 DOV-216,303 Free Base DOV-216,303(FreeBase)是有效的5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对hSERT、hNET和hDAT的IC50值分别为14nM，20nM和78nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
  20. GC33715 Fluoxetine (LY-110140)

    氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI）。氟西汀是大鼠和人血小板中饱和[3H]-5-HT摄取过程的强效抑制剂，IC50值分别为0.10和0.05 μM。
  21. GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) 是双重去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。
  22. GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白双重抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。
  23. GC31064 Duloxetine ((S)-Duloxetine) Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
  24. GC31041 Wf-516 Wf-516是一种5-HTreuptake的抑制剂，同时为5-HT1A和5-HT2A受体拮抗剂，对人体5-HT1A和5-HT2A受体的Ki值分别为5nM和40nM，具有抗抑郁作用。
  25. GC31029 Nitroxazepine (CIBA 2330Go) Nitroxazepine (CIBA 2330Go) 是一种用于抑郁症研究的三环类抗抑郁药 (TCA)。
  26. GC31020 SPD-473 citrate SPD-473citrate是5-HT/多巴胺/去甲肾上腺素再摄取抑制剂。
  27. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
  28. GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride)

    Amitifadine hydrochloride (DOV-21947 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺再摄取抑制剂 (SNDRI)，在 HEK 293 细胞中对 5-羟色胺、去甲肾上腺素和多巴胺的 IC50 分别为 12、23、96 nM。
  29. GC30772 Dopamine serotonin antagonist-1 Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  30. GC30375 Clomipramine D3 An Analytical Reference Standard
  31. GC19118 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。
  32. GC19117 Dasotraline Dasotraline 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。
  33. GC12885 Imipramine (hydrochloride) A tricyclic antidepressant
  34. GC14035 Citalopram hydrobromide A selective serotonin reuptake inhibitor
  35. GC10126 Desipramine hydrochloride Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET)、5-HT 转运蛋白 (SERT) 和多巴胺转运蛋白 (DAT) 的抑制剂，Kis 分别为 4、61 和 78,720 nM。
  36. GC11798 Cinchonidine Cinchonidine (α-Quinidine) 是一种金鸡纳生物碱，存在于金鸡纳 (Cinchona officinalis) 和 Gongronema latifolium 中。
  37. GC17061 Dapoxetine HCl An Analytical Reference Standard
  38. GC15107 Clomipramine HCl A tricyclic antidepressant
  39. GC17229 Paroxetine HCl A selective serotonin reuptake inhibitor
  40. GC14262 Desvenlafaxine Succinate An active metabolite of venlafaxine
  41. GC11570 Desvenlafaxine An active metabolite of venlafaxine
  42. GC12720 Sertraline HCl A selective serotonin reuptake inhibitor
  43. GC12055 Milnacipran HCl A serotonin and norepinephrine reuptake inhibitor
  44. GC14330 Milnacipran A serotonin and norepinephrine reuptake inhibitor
  45. GC13092 Fluvoxamine A selective serotonin reuptake inhibitor
  46. GC16797 Escitalopram Oxalate A selective serotonin reuptake inhibitor
  47. GC13161 Escitalopram A selective serotonin reuptake inhibitor
  48. GC13871 Duloxetine HCl A serotonin and norepinephrine reuptake inhibitor
  49. GC14437 Vortioxetine (Lu AA21004) HBr A multimodal serotonergic agent
  50. GC10911 Venlafaxine hydrochloride An Analytical Reference Material
  51. GC15025 Fluvoxamine maleate A selective serotonin reuptake inhibitor

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