PKA(蛋白激酶A)
PKA (protein kinase A), also known as cAMP-dependent protein kinase, has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
- Cat.No. 产品名称 Information
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GC69715
PKI (14-24)amide TFA
PKI (14-24)amide TFA 是一种有效的 PKA 抑制剂。PKI (14-24)amide 在细胞匀浆中强烈抑制环 AMP 依赖性蛋白激酶活性。
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GC69015
DS89002333
DS89002333 是一种口服有效的强效 PRKACA 抑制剂,其 IC50 值为 0.3 nM。DS89002333 在表达 DNAJB1-PRKACA 融合基因的 FL-HCC 患者源性异种移植模型中显示较好的抗肿瘤活性。DS89002333 可用于纤维化肝细胞癌 (FL-HCC) 的研究。
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GC65303
Jaspamycin
Jaspamycin (7-CN-7-C-Ino) 是一种有效的 PKA 激活剂,在 Trypanosoma brucei 中,与其 R 位点 (PKAR) 结合,EC50 和 Kd 值分别为 6.5 nM 和 8 nM。Jaspamycin (7-CN-7-C-Ino) 不结合纯化的人 PKARIα。具有抗寄生虫活性。
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GC64460
8-Chloro-cAMP
8-Chloro-cAMP 是一种 cAMP 类似物,可诱导生长停滞,并调节 cAMP 依赖性 PKA 活性。8-Chloro-cAMP 具有抗癌活性。
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GC63176
Rp-cAMPS sodium salt
Rp-cAMPS sodium salt,一种 cAMP 的类似物,是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的,竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。
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GC49440
ML-9
A PKB/Akt inhibitor
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GC49265
PKI (14-22) amide (myristoylated) (trifluoroacetate salt)
A PKA inhibitor
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GC61849
PKI 14-22 amide,myristoylated TFA
PKI 14-22 amide,myristoylated TFA 是一种有效的 cAMP 依赖性 PKA 抑制剂。PKI 14-22 amide,myristoylated TFA 可降低 IgG 介导的吞噬反应,也可抑制中性粒细胞粘附。
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GC61747
Sp-cAMPS
Sp-cAMPS,一种cAMP类似物,是一种依赖cAMP的PKAI和PKAII的有效激活剂。Sp-cAMPS还是一种有效的竞争性磷酸二酯酶(PDE3A)抑制剂,Ki为47.6µM。Sp-cAMPS以EC50为40μM来结合PDE10GAF域。
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GC61512
PKA Inhibitor Fragment (6-22) amide TFA
A synthetic peptide inhibitor of PKA
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GC60037
A-3 hydrochloride
A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
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GC50502
RI-STAD 2
AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
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GC50501
STAD 2
STAD 2 是 PKA-RII 的有效选择性破坏剂,Kd 为 6.2 nM。
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GC50407
st-Ht31 P
Negative control for st-Ht31
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GC50406
st-Ht31
Inhibits PKA/AKAP interactions; cell permeable
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GC50181
CW 008
PKA signaling activator; promotes osteogenesis from hMSCs
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GC36391
Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) 是一种磷酸受体肽,是环磷酸腺苷依赖性蛋白激酶 A (PKA) 的特异性底物。
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GC35565
Bucladesine calcium salt
Bucladesine 钙盐(Dibutyryl-cAMP 钙盐;DC2797 钙盐)是一种细胞可渗透的环 AMP (cAMP) 类似物,可通过增加细胞内 cAMP 水平选择性地激活 cAMP 依赖性蛋白激酶 (PKA)。
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GC35518
Bilobetin
A biflavonoid with diverse biological activities
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GC44853
Rp-8-CPT-Cyclic AMP (sodium salt)
A PKA inhibitor
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GC44653
PKA Inhibitor (5-24)
A synthetic peptide inhibitor of PKA
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GC33771
Metadoxine
Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.
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GC31525
CREBtide
CREBtide 是一种合成的 13 个氨基酸肽,已被报道为 PKA 底物。
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GC30857
Warangalone (Scandenolone)
Warangalone (Scandenolone) 是一种抗疟疾化合物,可抑制寄生虫 3D7(氯喹敏感)和 K1(氯喹抗性)两种菌株的生长,IC50 分别为 4.8 μg/mL 和 3.7 μg/mL。
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GC30545
Malantide
Malantide是一种十二肽,能够被PKA磷酸化,并且能够增强PKA的活性。
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GC19396
H 89
A PKA inhibitor
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GC19090
CCG215022
A GRK inhibitor
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GC15352
8-CPT-Cyclic AMP (sodium salt)
A cell-permeable cAMP analog
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GC16678
UCN-02
A PKC inhibitor
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GC12799
H-8 (hydrochloride)
A potent, nonspecific kinase inhibitor
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GC13640
Kemptide
A PKA substrate
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GC10428
Sp-5,6-dichloro-cBIMPS (sodium salt)
A selective PKA activator
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GC11605
C-1
C-1 是一种有效的蛋白激酶抑制剂,IC50 为 4 μM, 8 μM, 12 μM 和 240 μM 用于 cGMP 依赖性蛋白激酶 (PKG)、cAMP 依赖性蛋白激酶 (PKA) ,分别为蛋白激酶 C (PKC) 和 MLC 激酶。 C-1 也用作 ROCK 抑制剂。
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GC11362
K 252a
A non-selective PKC inhibitor
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GC17346
KT 5823
Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
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GC17712
AT13148
A multi-AGC kinase inhibitor
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GC12321
PKI 14-22 amide, myristoylated
A PKA inhibitor
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GC15525
cGMP Dependent Kinase Inhibitor Peptide
A cGMP-dependent protein kinase inhibitor
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GC10941
cAMPS-Rp, triethylammonium salt
A non-hydrolyzable analog of cAMP
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GC14648
KT 5720
A potent inhibitor of PKA
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GC12824
Dibutyryl-cAMP, sodium salt
A cell-permeable, cAMP analog
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GC16929
8-Bromo-cAMP, sodium salt
A PKA activator
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GC13869
Fasudil
Fasudil (HA-1077; AT877) 是一种非特异性 RhoA/ROCK 抑制剂,对蛋白激酶也有抑制作用,对 ROCK1 的 Ki 为 0.33 μM,对 ROCK2 和 PKA 的 IC50 分别为 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM ,PKC,PKG,分别。 Fasudil 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
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GC10074
H 89 2HCl
A PKA inhibitor
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GC14289
Fasudil (HA-1077) HCl
Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
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GC12297
AT7867
A potent and orally bioavailable pan-Akt inhibitor
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GC17255
Gliotoxin
An immunosuppressive mycotoxin with diverse biological effects
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GC10918
AT7867 dihydrochloride
A potent and orally bioavailable pan-Akt inhibitor
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GN10336
Daphnetin
A coumarin derivative with diverse biological activities
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GC15299
Staurosporine(CGP 41251)
A potent inhibitor of protein kinase C