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UCN-02 Sale

(Synonyms: 7-epi-hydroxy Staurosporine) 目录号 : GC16678

A PKC inhibitor

UCN-02 Chemical Structure

Cas No.:121569-61-7

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1mg
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5mg
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产品描述

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

Protein kinase C (PKC), which can phosphorylate serine and threonine, is a family of protein kinase enzymes involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been implicated in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].

UCN-02 inhibited protein kinase C with a slightly reduced potency than UCN-01. The IC50 values were 62 and 4.1 nM for UNC-02 and UCN-01, respectively. UCN-02 was cytotoxic to the growth of HeLa S3 cells.

References:
[1] Takahashi, I. ,Saitoh, Y.,Yoshida, M., et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J.Antibiot.(Tokyo) 42(4), 571-576 (1989).
[2] Newton A C.  Protein kinase C: structure, function, and regulation[J]. Journal of Biological Chemistry, 1995, 270(48): 28495-28498.

Chemical Properties

Cas No. 121569-61-7 SDF
别名 7-epi-hydroxy Staurosporine
化学名 (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Canonical SMILES [H][C@]12N(C3=C(N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C4=C5C=CC=C4)C5=C([C@H](O)NC6=O)C6=C37)C8=C7C=CC=C8
分子式 C28H26N4O4 分子量 482.5
溶解度 Ethanol: 1 mg/ml 储存条件 Store at -20°C
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1 mM 2.0725 mL 10.3627 mL 20.7254 mL
5 mM 0.4145 mL 2.0725 mL 4.1451 mL
10 mM 0.2073 mL 1.0363 mL 2.0725 mL
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