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Bucladesine calcium salt Sale

(Synonyms: 二丁酰环磷腺苷钙,Dibutyryl cAMP calcium salt; DBcAMP calcium salt) 目录号 : GC35565

Bucladesine 钙盐(Dibutyryl-cAMP 钙盐;DC2797 钙盐)是一种细胞可渗透的环 AMP (cAMP) 类似物,可通过增加细胞内 cAMP 水平选择性地激活 cAMP 依赖性蛋白激酶 (PKA)。

Bucladesine calcium salt Chemical Structure

Cas No.:938448-87-4

规格 价格 库存 购买数量
10mM (in 1mL Water)
¥644.00
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50mg
¥585.00
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100mg
¥720.00
现货
200mg 待询 待询
500mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Bucladesine calcium salt (Dibutyryl-cAMP calcium salt; DC2797 calcium salt) is a membrane permeable selective activator of PKA.Target: PKABucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats [1]. Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine [2]. Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin [3]. Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice [4].

[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. [2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7. [3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43. [4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.

Chemical Properties

Cas No. 938448-87-4 SDF
别名 二丁酰环磷腺苷钙,Dibutyryl cAMP calcium salt; DBcAMP calcium salt
Canonical SMILES O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4([O-])=O.[0.5Ca2+]
分子式 C18H23Ca0.5N5O8P 分子量 488.42
溶解度 Water: 100 mg/mL (204.74 mM); DMSO: ≥ 100 mg/mL (204.74 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0474 mL 10.2371 mL 20.4742 mL
5 mM 0.4095 mL 2.0474 mL 4.0948 mL
10 mM 0.2047 mL 1.0237 mL 2.0474 mL
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