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TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. 产品名称 Information
  2. GC12842 Bryostatin 2 Protein kinase C (PKC) activator
  3. GC12695 Bryostatin 3 protein kinase C activator
  4. GC16539 Butaprost
  5. GC11605 C-1 protein kinase C inhibitor
  6. GC43105 C8 Ceramide (d18:1.8:0)

    A cell-permeable analog of naturally occurring ceramides

  7. GC11159 Calphostin C protein kinase C inhibitor
  8. GC62612 CC-90005 CC-90005 是一种有效,选择性和具有口服活性的蛋白激酶 C-θ (PKC-θ) 抑制剂,IC50 值为 8 nM。CC-90005 显示了对 PKC-θ 的选择性超过 PKC-δ (IC50=4440 nM)。CC-90005 可以通过 IL-2 表达抑制 T 细胞活化。
  9. GC38898 CCG-222740 CCG-222740 是一种有效的,选择性 Rho/MRTF 途径抑制剂。CCG-222740 也是有效的 α-平滑肌肌动蛋白蛋白表达抑制剂。CCG-222740 有效减少皮肤纤维化并阻止黑色素瘤转移。
  10. GC35651 Cenisertib Cenisertib (AS-703569) 是一种多激酶抑制剂,可抑制 Aurora-kinase-A/B,ABL1,AKT,STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌,乳腺癌,结肠癌,卵巢癌和肺癌以及白血病的肿瘤生长。
  11. GC18521 Cercosporin Cercosporin is a pigmented phytotoxin isolated from the fungus C.
  12. GC10687 CGP 53353 PKCβII inhibitor
  13. GC14650 CGP60474 CDKs and PKC inhibitor, potent
  14. GC32250 Chebulinic acid Chebulinicacid是一个天然的M.tuberculosisDNAgyrase抑制剂,也能抑制SMAD-3phosphorylation和H+K+-ATPase的活性。
  15. GN10463 Chelerythrine PKC inhibitor
  16. GC13065 Chelerythrine Chloride PKC antagonist
  17. GC35682 CHMFL-ABL/KIT-155 CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) 是一种高效的,具有口服活性的 type II ABL/c-KIT 双激酶抑制剂 (IC50 分别为 46 nM 和 75 nM),对 BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM), PDGFRβ (IC50=80 nM) 激酶也具有明显的抑制活性。CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) 阻止细胞周期进展和诱导细胞凋亡。
  18. GC16097 chroman 1 ROCK II inhibitor, highly potent and selective
  19. GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
  20. GC43286 CMPD101 A GRK2 and GRK3 inhibitor
  21. GC63333 Cotosudil Cotosudil 是一种 ROCK 激酶抑制剂,可用于青光眼或高眼压症的研究。
  22. GC50704 CRT 0066854 hydrochloride
  23. GC45414 CRT0066854  
  24. GC35753 CT-721 CT-721 是一种有效的,时间依赖性的 Bcr-Abl 激酶抑制剂,抑制野生型 Bcr-Abl 激酶的 IC50 值为 21.3 nM,具有抗慢性骨髓白血病 (CML) 活性。
  25. GC33351 CZC-8004 (CZC-00008004) CZC-8004是一种广泛的激酶抑制剂,可与多种酪氨酸激酶结合,包括ABL激酶。
  26. GC17591 D-erythro-Sphingosine (synthetic) protein kinase C and calmodulin-dependent enzymes inhibitor
  27. GN10336 Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC
  28. GC38186 Daphnoretin A coumarin with diverse biological activities
  29. GC15568 Dasatinib (BMS-354825) Src and BCR-Abl inhibitor
  30. GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor
  31. GC15884 Dasatinib Monohydrate Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases.
  32. GC14007 DCC-2036 (Rebastinib) Bcr-Abl inhibitor
  33. GC38388 DCPLA-ME DCPLA-ME 是 DCPLA 的甲酯形式。DCPLA-ME 是一种有效的 PKCε 激活剂。DCPLA-ME 可用于治疗神经退行性疾病。
  34. GC31892 Decursin ((+)-Decursin) Decursin是一种抗癌物质,并具有潜在的抗炎活性。
  35. GC38085 Decursinol angelate Decursinol angelate 是从 Angelica gigas 根部分离得到的一种细胞毒性物质,是 PKC 激酶的激活剂,拥有抗肿瘤和抗炎活性。
  36. GC16354 Dequalinium Chloride anti-tumor agent and PKC inhibitor
  37. GC38482 Desmethylglycitein Desmethylglycitein (4',6,7-Trihydroxyisoflavone),大豆苷元的代谢产物,来源于大豆 Glycine max,具有抗氧化性和抗癌活性。Desmethylglycitein 在体内直接结合 CDK1 和 CDK2,抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线 (sUV) 诱导的基质金属蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 竞争方式与细胞质中的 PI3K 结合,抑制 PI3K 和下游信号级联的活性,从而抑制 3T3-L1 前脂肪细胞中的脂肪形成。
  38. GC17767 Dihydrosphingosine

    Protein kinase C inhibitor

  39. GC34060 Disitertide (P144)

    An inhibitor of TGF-β1

  40. GC60782 Disitertide TFA Disitertide(P144)TFA是转化生长因子TGFβ1的多肽抑制剂,特异性的阻断其与受体间的相互作用。Disitertide(P144)TFA也是PI3K的抑制剂和凋亡(apoptosis)诱导剂。
  41. GC14298 DMH-1 Selective BMP ALK2 receptor
  42. GC17243 Dorsomorphin (Compound C)

    AMPK inhibitor

  43. GC12560 Dorsomorphin (Compound C) 2HCl

    AMPK inhibitor

  44. GC35897 DPH A potent cell permeable c-Abl activator
  45. GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo,TGF-β和Wnt信号通路的抑制剂,并拥有抗肿瘤活性。
  46. GC11499 Enzastaurin (LY317615) PKC beta inhibitor,potent and selective
  47. GC13354 EW-7197 Selective inhibitor of TGF-β type I receptor kinase
  48. GC13869 Fasudil Calcium antagonist
  49. GC14289 Fasudil (HA-1077) HCl Protein kinase inhibitor
  50. GC32867 Flumatinib (HHGV678) Flumatinib(HHGV678)是多种激酶抑制剂,对c-Abl,PDGFRβ和c-Kit的IC50为1.2nM,307.6nM和2662nM。
  51. GC13914 Flumatinib mesylate PDGRFβ inhibitor

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