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TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. 产品名称 Information
  2. GC17815 L-threo-Sphingosine C-18 protein kinase C inhibitor
  3. GC16580 LDN-193189 ALK inhibitor,potent and selective
  4. GC17035 LDN-212854 BMP receptor inhibitor,potent and selective
  5. GC13225 LDN-214117 potent and selective ALK2 inhibitor
  6. GC14931 LDN193189 Hydrochloride ALK inhibitor,potent and selective
  7. GC36433 LDN193189 Tetrahydrochloride A selective BMP type I receptor inhibitor
  8. GC39398 LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)

    LSKL, Inhibitor of Thrombospondin (TSP-1) TFA 是一种衍生自 LAP-TGFβ 的四肽,是一种竞争性的 TGF-β1 拮抗剂。LSKL, Inhibitor of Thrombospondin (TSP-1) TFA 抑制 TSP-1 与 LAP 的结合并减轻肾间质纤维化和肝纤维化。LSKL, Inhibitor of Thrombospondin (TSP-1) TFA 通过抑制 TSP-1 介导的 TGF-β1 活性来抑制蛛网膜下纤维化,防止慢性脑积水的发生并改善蛛网膜下腔出血后的长期神经认知缺陷。LSKL, Inhibitor of Thrombospondin (TSP-1) TFA 可以轻松穿越血脑屏障。

  9. GC32728 LSKL, Inhibitor of Thrombospondin TSP-1

    LSKL,InhibitorofThrombospondin(TSP-1)是一种四肽,源于潜在联系多肽,能够抑制TSP-1的活性,来降低TGF-β的活性,能够阻止肝损伤和肝纤维化。

  10. GC12402 LX7101 HCL Dual LIM-kinase and ROCK inhibitor
  11. GC32811 LXS196 LXS196是有效的、选择性的和具有口服活性的蛋白激酶C(PKC)抑制剂,对PKCα、PKCθ和GSK3β的IC50值分别为1.9nM、0.4nM和3.1μM。可用于治疗葡萄膜黑素瘤。
  12. GC17563 LY 333531 hydrochloride PKCβ inhibitor
  13. GC12363 LY2109761 TβRI/II kinase inhibitor
  14. GC18015 LY2157299 TGF-βR1 inhibitor,potent and selective
  15. GC19234 LY3200882 LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
  16. GC11604 LY364947

    Inhibitor of TGF-β type I receptor kinase domain

  17. GC30545 Malantide Malantide是一种十二肽,能够被PKA磷酸化,并且能够增强PKA的活性。
  18. GC10496 Midostaurin (PKC412) A PKC inhibitor
  19. GC32714 Mitoxantrone (mitozantrone) Mitoxantrone是拓扑异构酶II(topoisomeraseII)的抑制剂;也可抑制蛋白激酶C(PKC),IC50值为8.5μM。
  20. GC14363 Mitoxantrone HCl Mitoxantrone 2HCl是Mitoxantrone的盐酸盐形式,是一种合成的抗肿瘤蒽二酮(IC50为0.42 mM)。
  21. GC17582 ML347 BMP receptor inhibitor,potent and selective
  22. GC63778 Myelin Basic Protein TFA Myelin Basic Protein (MHP4-14) TFA 是一种合成肽,包含髓鞘碱性蛋白的残基4-14,是一种非常有选择性的 PKC 底物 (Km=7 μM)。Myelin Basic Protein TFA 不被环腺苷酸依赖性蛋白激酶、酪蛋白激酶 I 和 II、Ca2+/钙调素依赖性蛋白激酶 II 或磷酸化酶激酶磷酸化,可常规用于测定粗组织提取物中低背景的蛋白激酶C。
  23. GC49269 Myr-ZIP A PKMζ inhibitor
  24. GC44303 N-Acetylpuromycin N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S.
  25. GC38931 N-Desmethyltamoxifen hydrochloride N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内的主要代谢产物。N-Desmethyltamoxifen,较弱的抗雌激素,是一种比 Tamoxifen 强十倍的蛋白激酶 C (PKC) 抑制剂。N-Desmethyltamoxifen hydrochloride 也是人体 AML 细胞神经酰胺代谢的有效调节因子,限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
  26. GC12491 Narciclasine Modulates the Rho/ROCK/LIM kinase/cofilin pathway
  27. GC10716 Netarsudil (AR-13324) ROCK inhibitor
  28. GC13514 NG25

    TAK1 inhibitor

  29. GC14237 Nilotinib monohydrochloride monohydrate Bcr-Abl inhibitor
  30. GC14129 Nilotinib(AMN-107) Bcr-Abl kinase inhibitor,selective
  31. GC14075 Nocodazole A tubulin production inhibitor,anti-neoplastic agent
  32. GC60274 O-Desmethyl Midostaurin O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin 的活性代谢物,通过细胞色素 P450 肝酶代谢产生,可以作为 Midostaurin 在体内代谢的指标之一。Midostaurin 是一种多靶点蛋白激酶 (kinase) 抑制剂,IC50 范围为 22-500 nM。
  33. GC62207 Olverembatinib GZD824 (HQP1351) 是一种高效的,具有口服活性的 pan-Bcr-Abl 抑制剂。GZD824 能广泛而有效地抑制突变型 Bcr-Abl。GZD824 对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的 IC50 值分别为 0.34 nM 和 0.68 nM。GZD824 具有抗肿瘤作用。
  34. GC36807 ON 146040 ON 146040 是一种有效的 PI3Kα 和 PI3Kδ 抑制剂,IC50 分别约为 14 和 20 nM。ON 146040 也抑制 Abl1 (IC50<150 nM)。
  35. GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
  36. GN10378 Oxymatrine Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective.1 Traditional chinese medicine used in the treatment against hepatitis B virus.2
  37. GC36833 p32 Inhibitor M36 p32 inhibitor M36 (M36) 是一种 p32 线粒体蛋白小分子抑制剂,可直接与 p32 结合,抑制 p32 与 LyP-1 的结合。
  38. GC12637 PD 180970 P210bcr/abl tyrosine kinase inhibitor
  39. GC13592 PD173955 Dual Src/Abl kinase inhibitor, ATP-competitive,
  40. GC61585 Pep2m, myristoylated TFA Pep2m,myristoylatedTFA(Myr-Pep2mTFA)是一种细胞通透性肽。Pep2m,myristoylatedTFA能破坏蛋白激酶ζ(PKMζ)下游靶点NSF/GluR2相互作用。PKMζ具有自主活性的PKC同工酶。
  41. GC14767 PF-00562271 FAK/Pyk2 inhibitor,potent and ATP-competitive
  42. GC14407 PF-431396 Pyk2 and FAK inhibitor
  43. GC61852 PF-4618433 PF-4618433 是一种有效的、选择性的 PYK2 抑制剂,IC50 值为 637 nM。PF-4618433 可能适用于研究骨质疏松症,颅面和阑尾骨骼缺损以及靶向骨再生。
  44. GC15380 PF-562271 ATP-competitive FAK inhibitor, reversible
  45. GC10810 PF-562271 HCl FAK/Pyk2 inhibitor
  46. GC17352 Phorbol 12,13-dibutyrate Protein kinase C activator
  47. GC12790 Pirfenidone TGF-β production inhibitor
  48. GC40197 Pirfenidone-d5 Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS.
  49. GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C
  50. GC10404 PKC ζ pseudosubstrate Inhibitor of protein kinase C (PKC) ζ
  51. GC11671 PKC fragment (530-558) Potent activator of protein kinase C

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