TGF-βR1(ALK5)

TGF-βR1 (transforming growth factor beta receptors) are a serine/threonine protein kinase that involved in the regulation of cell cycle arrest, cell proliferation and differentiation, production of extracellular matrix, wound healing, tumorgenesis and immunosuppression etc.

Products for TGF-βR1(ALK5)

Cat.No. 产品名称 Information
GC11050 ALK5 Inhibitor II (hydrochloride)
E 616452,RepSox,SJN 2511
A selective inhibitor of ALK5
GC17582 ML347
LDN 193719
A selective ALK1 and ALK2 inhibitor
GC17035 LDN-212854
5-（6-（4-（哌嗪-1-基）苯基）吡唑并[1,5-a]嘧啶-3-基）喹啉
An ALK2 inhibitor
GC14298 DMH-1
BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482
A potent ALK2 inhibitor
GC15567 K02288 A BMP signaling inhibitor
GC12363 LY2109761 A dual inhibitor of TGF-β type 1/type II receptor kinases
GC18015 LY2157299
LY-2157299;LY 2157299
LY2157299是一种口服的、选择性TGF-β受体I型（TGF-βRI）激酶抑制剂，IC₅₀值为56nM。
GC11878 GW788388 An inhibitor of ALK5 (TGFBR1)
GC14349 SB525334
6-[2-(1,1-二甲基乙基)-5-(6-甲基-2-吡啶基)-1H-咪唑-4-基]喹喔啉
SB525334已被鉴定为一种高效且选择性的转化生长因子β1（TGF-β1）受体、活化素受体样激酶（ALK5）抑制剂。SB525334对ALK5激酶活性的IC₅₀为14.3nM。
GC11545 SB 431542 SB-431542是一种小分子抑制剂，可以阻止TGF-β受体类型I的内部介导物，从而降低TGF-β1介导的增殖、细胞因子和胶原蛋白表达。
GC13904 SD-208
SD 208; SD208
A potent, selective inhibitor of TGF-βRI
GC10421 SB-505124 hydrochloride
SB 505124 hydrochloride;SB505124 hydrochloride
Inhibitor of receptors ALK4, ALK5, and ALK7
GC10166 A 83-01
3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺,A83-01;A-83-01
A 83-01 是 TGF-β I 型受体 ALK5 激酶、I 型淋巴结受体 ALK4 和 I 型淋巴结受体 ALK7 的有效抑制剂，IC50 s 分别为 12 nM、45 nM和 7.5 nM 分别抑制 ALK5、ALK4 和 ALK7 诱导的转录。
GC13927 A 77-01
A77-01;A-77-01
A potent ALK5 inhibitor