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ML347 Sale

(Synonyms: LDN 193719) 目录号 : GC17582

A selective ALK1 and ALK2 inhibitor

ML347 Chemical Structure

Cas No.:1062368-49-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥483.00
现货
5mg
¥420.00
现货
10mg
¥651.00
现货
50mg
¥2,688.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

ML347 is a potent and selective inhibitor of bone morphogenetic protein (BMP) receptor with IC50 value of 32nM against ALK2 [1].

ML347 is discovered as a selective inhibitor of BMP type-I receptor ALK2 versus ALK3 and is identified as a probe molecule. In the in vitro kinase assay, ML347 shows potent inhibitory activities against ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. The IC50 value of it for ALK3 is more than 10μM, demonstrating that ML347 is 300-fold more potent against ALK2. Besides that, ML347 exerts no inhibition effect on other related kinases such as ALK6 and KDR. Moreover, ML347 also shows effective inhibition with IC50 value of 152nM in the BMP4 cell based assay using C2C12BRA cells [1].

References:
[1] Engers D W, Frist A Y, Lindsley C W, et al. Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo [1.5-a] pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & medicinal chemistry letters, 2013, 23(11): 3248-3252.

Chemical Properties

Cas No. 1062368-49-3 SDF
别名 LDN 193719
Canonical SMILES COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2
分子式 C22H16N4O 分子量 352.39
溶解度 ≥ 5.87mg/mL in DMSO with gentle warming 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.8378 mL 14.1888 mL 28.3776 mL
5 mM 0.5676 mL 2.8378 mL 5.6755 mL
10 mM 0.2838 mL 1.4189 mL 2.8378 mL
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