DNA Methyltransferase(DNA甲基转移酶)
DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.
- Cat.No. 产品名称 Information
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GC65546
DNMT3A-IN-1
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GC65242
TFMB-(S)-2-HG
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GC64733
Procainamide
An Analytical Reference Standard
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GC64210
(R)-GSK-3685032
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GC63483
GSK-3685032
GSK3685032 is a non-time-dependent, highly selective enzymatic inhibitor of DNA methyltransferase (DNMT1) with IC50 of 0.036 μM, and over 2500-fold more selective than DNMT3A/3L and DNMT3B/3L.
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GC61662
5-Fluoro-2'-deoxycytidine
2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.
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GC60310
Psammaplin A
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GC36196
Guadecitabine sodium
Guadecitabine sodium (SGI-110 sodium) 是第二代 DNA 甲基转移酶 (DNMT) 抑制剂,用于研究急性髓性白血病 (AML) 和骨髓增生异常综合征 (MDS)。
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GC36153
Glucose-conjugated MGMT inhibitor
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GC35714
CM-579 trihydrochloride
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GC35180
6-Methyl-5-azacytidine
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GC42562
5-Methyl-2'-deoxycytidine
A pyrimidine nucleoside
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GC34498
Bobcat339 hydrochloride
A cytosine derivative
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GC33320
CM-579
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GC33148
DC-05
A non-nucleoside DNMT1 inhibitor
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GC32872
DC_517
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GC31365
γ-Oryzanol
Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
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GC11302
Hinokitiol
A tropolone with diverse biological activities
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GC12367
CM-272
An inhibitor of G9a, GLP, and DNA methyltransferases
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GC14364
SGI-1027
A DNA methyltransferase inhibitor
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GC17428
SGI-110
SGI-110 (SGI-110) 是第二代 DNA 甲基转移酶 (DNMT) 抑制剂,用于研究急性髓性白血病 (AML) 和骨髓增生异常综合征 (MDS)。
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GC14366
Thioguanine
A thiopurine analog
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GC12153
Zebularine
A DNA methyltransferase inhibitor
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GC13398
RG 108
DNA methyltransferase inhibitor
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GC11778
Lomeguatrib
Inactivator of O6-methylguanine-DNA methyltransferase
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GC10946
5-Azacytidine
A DNA methyltransferase inhibitor
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GC15255
Decitabine(NSC127716, 5AZA-CdR)
A 2’ deoxy analog of 5-azacytidine