HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
- Cat.No. 产品名称 Information
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GC25552
KT-531
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
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GC25139
Biphenyl-4-sulfonyl chloride
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
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GC67984
Alteminostat
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GC67674
CRA-026440 hydrochloride
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GC66055
5-Phenylpentan-2-one
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GC66052
HDAC-IN-40
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GC65965
MPT0E028
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GC65460
HDACs/mTOR Inhibitor 1
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GC65426
CM-675
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GC65330
AES-135
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GC65206
FT895
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GC64968
SW-100
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GC64959
JAK/HDAC-IN-1
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GC64942
CHDI-390576
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GC64761
Butyric acid-13C1
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GC64729
MPT0B390
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GC64684
SB-429201
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GC64378
Valproic acid-d6
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GC64191
Elevenostat
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GC63730
QTX125 TFA
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GC63703
Ivaltinostat formic
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GC62461
FNDR-20123
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GC62430
KA2507
KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
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GC62411
QTX125
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GC62374
KA2507 monohydrochloride
KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
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GC62308
MPT0G211
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GC61947
Triciferol
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GC61029
Marein
A glucoside chalcone with diverse biological activities
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GC60310
Psammaplin A
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GC39679
CG347B
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GC50322
BRD 9757
Potent and selective HDAC6 inhibitor
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GC39214
1-Naphthohydroxamic acid
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GC38742
BRD-6929
An HDAC1 and HDAC2 inhibitor
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GC45906
MC1742
An inhibitor of class I and class IIb HDACs
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GC45717
Chlamydocin
An HDAC inhibitor
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GC38412
Crotonoside
A guanosine analog with diverse biological activities
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GA20605
Ac-Lys-AMC
Ac-Lys-AMC(己酰胺),也称为 MAL,是组蛋白去乙酰化酶 HDAC 的荧光底物。
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GA20481
Ac-Arg-Gly-Lys(Ac)-AMC
Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。
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GC37845
Tucidinostat
An HDAC inhibitor
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GC37753
Tefinostat
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GC37643
SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
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GC36905
PI3K/HDAC-IN-1
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GC36691
Nanatinostat
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GC36690
Nampt-IN-3
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GC35893
Domatinostat
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
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GC35668
CG-200745
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GC35551
BRD 4354 ditrifluoroacetate
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GC41085
HDAC6 Inhibitor
An inhibitor of HDAC6
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GC34629
J22352
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GC34458
ACY-1083