HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
Products for HDAC
- Cat.No. 产品名称 Information
- GC15410 Bufexamac An NSAID and a class IIb HDAC inhibitor
- GC11424 Valproic acid A class I HDAC inhibitor
- GC16143 Varenicline Hydrochloride Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
- GC17703 TMP269 A selective class IIa HDAC inhibitor
-
GC14285
RGFP966
RGFP966是HDAC3抑制剂,IC50为0.08 μM。RGFP966可以抑制炎症反应。
- GC10322 Tubastatin A HCl A potent HDAC6 inhibitor
- GC12019 TCS HDAC6 20b An HDAC6 inhibitor
- GC13237 LMK 235 A selective inhibitor of HDAC4 and HDAC5
-
GC16386
Tubacin
Tubacin (tubulin acetylation inducer) is a small molecule that selectively inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin with IC50 of 0.004µM
- GC13591 TC-H 106 A tight-binding inhibitor of class I HDACs
- GC11095 Pyroxamide A HDAC inhibitor
- GC15040 NSC 3852 A tumor cell differentiating agent
- GC15536 NCH 51 An HDAC inhibitor
- GC13435 KD 5170 An inhibitor of class I and II HDACs
- GC14340 Tasquinimod An orally-active anti-cancer compound
- GC10423 RG2833 An HDAC inhibitor
- GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor
- GC15830 Daminozide Selective inhibitor of KDM2/7 histone demethylases
- GC11975 CHAPS CHAPS 是胆酸的衍生物,是一种用于溶解膜蛋白的两性离子去污剂。
- GC16456 M344 HDAC inhibitor
-
GC14590
AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
- GC15114 LAQ824 (NVP-LAQ824,Dacinostat) A hydroxamate-based HDAC inhibitor
- GC13408 CI994 (Tacedinaline) An inhibitor of HDAC1, -2, and -3
-
GC10839
Tubastatin A
A potent HDAC6 inhibitor
- GC13706 Droxinostat An inhibitor of HDAC3, HDAC6, and HDAC8
- GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
- GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor
- GC12115 CUDC-907 A dual inhibitor of HDACs and PI3Ks
-
GC15962
Belinostat (PXD101)
Belinostat 是一种有效的 HDAC 抑制剂, 在 HeLa 细胞提取物中的 IC50 为 27 nM。
-
GC16734
Pracinostat (SB939)
A pan-HDAC inhibitor
- GC15965 MC1568 A selective class IIa HDAC inhibitor
- GC15879 Resminostat (RAS2410) Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂,平均 IC50 值分别为 42.5、50.1、71.8 nM,对 HDAC8 的活性较低,IC50 为 877 nM .
- GC15002 Sodium Phenylbutyrate A chemical chaperone
- GC15315 Scriptaid HDAC inhibitor
-
GC17836
ITF2357 (Givinostat)
HDAC inhibitor with anti-inflammatory and antineoplastic activities
- GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2
- GC18008 PCI-34051 A potent, selective HDAC8 inhibitor
- GC15476 JNJ-26481585 A pan-HDAC inhibitor
- GC13055 Mocetinostat (MGCD0103, MG0103) An orally available HDAC inhibitor
-
GC17390
Vorinostat (SAHA, MK0683)
An HDAC inhibitor
- GC14998 Rocilinostat (ACY-1215) A selective inhibitor of HDAC6
- GN10357 Parthenolide A natural inhibitor of NOD2 and NF-κB signaling
-
GC12961
Apicidin
A cell-permeable HDAC inhibitor
- GC11334 Romidepsin (FK228, depsipeptide) A class I HDAC inhibitor
- GC15526 Trichostatin A (TSA) A potent, reversible inhibitor of histone deacetylases
- GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor
- GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor