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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. 产品名称 Information
  2. GC19406 TH34 TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。
  3. GC19360 TMP195

    TMP195游离态

    TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。
  4. GC19337 SR-4370 An HDAC3 inhibitor
  5. GC19190 HDAC-IN-4

    CXD101

     An HDAC inhibitor
  6. GC19189 HDAC8-IN-1

    MDK-7933

     An HDAC8 inhibitor
  7. GC19129 EDO-S101

    Tinostamustine

     An HDAC inhibitor and DNA alkylating agent
  8. GC19020 ACY-738

    N-羟基-2-[(1-苯基环丙基)氨基]-5-嘧啶甲酰胺

     An HDAC6 inhibitor
  9. GC18402 GSK3117391 An HDAC inhibitor
  10. GC18206 WT161 A potent inhibitor of HDAC6
  11. GC11949 MI-192 A selective HDAC2/3 Inhibitor
  12. GC14016 Sulforaphane

    萝卜硫素

    萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。
  13. GC14058 CBHA

    Histone Deacetylase Inhibitor II,m-Carboxycinnamic Acid bis-Hydroxamide

     Inhibitor of histone deacetylases
  14. GC12334 HNHA

    N-羟基-7-(2-萘硫基)-庚酰胺,Histone Deacetylase Inhibitor VI

     HDAC inhibitor
  15. GC13925 Nullscript A negative control for scriptaid
  16. GC14597 ITSA-1 (ITSA1)

    ITSA-1 是一种组蛋白去乙酰化酶（HDAC）激活剂，能够抑制HDAC抑制剂TSA对HDAC的抑制，但不抑制其他HDAC抑制剂。
  17. GC17472 Oxamflatin

    Metacept-3

     Inhibitor of histone deacetylases
  18. GC12822 BML-210(CAY10433)

    NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433

     A potent, synthetic HDAC inhibitor
  19. GC14367 UF 010 A class I HDAC inhibitor
  20. GC12074 BG45 A selective HDAC3 inhibitor
  21. GC10417 ACY-241

    西他司他,Citarinostat

     An HDAC6 inhibitor
  22. GC16042 Chidamide

    西达本胺,Chidamide impurity

     An HDAC inhibitor
  23. GC11360 ORY-1001

    N1-(反式-2-苯基环丙基)环己烷-1,4-二胺二盐酸盐

     An LSD1 inhibitor
  24. GC12484 BRD73954 A dual inhibitor of HDAC6 and HDAC8
  25. GC11574 HPOB A potent and selective inhibitor of HDAC6
  26. GC12971 CAY10603

    BML-281

     An exceptionally potent inhibitor of HDAC6
  27. GC14439 Santacruzamate A (CAY10683)

    HDAC抑制剂,CAY-10683

     A histone deacetylase inhibitor
  28. GC12667 4SC-202

    4SC-202(盐的形式),4SC-202

     An HDAC1-3 and KDM1A inhibitor
  29. GC13764 Nexturastat A A potent, cell-permeable HDAC6 inhibitor
  30. GC15857 Sodium butyrate

    丁酸钠

     A short-chain fatty acid and HDAC inhibitor
  31. GC15410 Bufexamac

    丁苯羟酸; Bufexamic acid

     An NSAID and a class IIb HDAC inhibitor
  32. GC11424 Valproic acid

    丙戊酸; VPA; 2-Propylpentanoic Acid

     A class I HDAC inhibitor
  33. GC16143 Varenicline Hydrochloride

    6,7,8,9-四氢-6,10-甲桥-6H-吡嗪并[2,3-H][3]苯并氮杂卓盐酸盐,CP 526555 hydrochloride

     Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
  34. GC17703 TMP269

    TMP 269;TMP-269

     A selective class IIa HDAC inhibitor
  35. GC14285 RGFP966

    RGFP 966;RGFP-966

     RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。
  36. GC10322 Tubastatin A HCl

    TubastatinA盐酸盐,TSA HCl;Tubastatin A hydrochloride

     A potent HDAC6 inhibitor
  37. GC12019 TCS HDAC6 20b An HDAC6 inhibitor
  38. GC13237 LMK 235

    N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺

     A selective inhibitor of HDAC4 and HDAC5
  39. GC16386 Tubacin

    HDAC6抑制剂

     Tubacin (tubulin acetylation inducer)是一种选择性抑制组蛋白去乙酰化酶6 (HDAC6)，诱导α-微管蛋白乙酰化的小分子，IC50为0.004µM。
  40. GC13591 TC-H 106

    RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII

     A tight-binding inhibitor of class I HDACs
  41. GC11095 Pyroxamide

    N-羟基-N'-3-吡啶基辛二酰胺

     A HDAC inhibitor
  42. GC15040 NSC 3852

    8-羟基-5-硝基喹啉

     A tumor cell differentiating agent
  43. GC15536 NCH 51

    NCH-51

     An HDAC inhibitor
  44. GC13435 KD 5170 An inhibitor of class I and II HDACs
  45. GC14340 Tasquinimod

    他喹莫德; ABR-215050

     An orally-active anti-cancer compound
  46. GC10423 RG2833

    RG 2833;RG-2833;RGFP-109;RGFP109;RGFP 109

     An HDAC inhibitor
  47. GC14243 Resminostat hydrochloride

    RAS2410 hydrochloride;4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS-2410 hydrochloride

     An orally bioavailable HDAC inhibitor
  48. GC15830 Daminozide

    丁酰肼

     Selective inhibitor of KDM2/7 histone demethylases
  49. GC11975 CHAPS

    3-[3-(胆酰胺丙基)二甲氨基]丙磺酸内盐

     CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
  50. GC16456 M344

    4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺,Histone Deacetylase Inhibitor III,MS344

     HDAC inhibitor
  51. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

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