Home >> Signaling Pathways >> DNA Damage/DNA Repair >> HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. 产品名称 Information
  2. GC15410 Bufexamac An NSAID and a class IIb HDAC inhibitor
  3. GC11424 Valproic acid A class I HDAC inhibitor
  4. GC16143 Varenicline Hydrochloride Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
  5. GC17703 TMP269 A selective class IIa HDAC inhibitor
  6. GC14285 RGFP966

    RGFP966是HDAC3抑制剂,IC50为0.08 μM。RGFP966可以抑制炎症反应。

  7. GC10322 Tubastatin A HCl A potent HDAC6 inhibitor
  8. GC12019 TCS HDAC6 20b An HDAC6 inhibitor
  9. GC13237 LMK 235 A selective inhibitor of HDAC4 and HDAC5
  10. GC16386 Tubacin

    Tubacin (tubulin acetylation inducer) is a small molecule that selectively inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin with IC50 of 0.004µM

  11. GC13591 TC-H 106 A tight-binding inhibitor of class I HDACs
  12. GC11095 Pyroxamide A HDAC inhibitor
  13. GC15040 NSC 3852 A tumor cell differentiating agent
  14. GC15536 NCH 51 An HDAC inhibitor
  15. GC13435 KD 5170 An inhibitor of class I and II HDACs
  16. GC14340 Tasquinimod An orally-active anti-cancer compound
  17. GC10423 RG2833 An HDAC inhibitor
  18. GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor
  19. GC15830 Daminozide Selective inhibitor of KDM2/7 histone demethylases
  20. GC11975 CHAPS CHAPS 是胆酸的衍生物,是一种用于溶解膜蛋白的两性离子去污剂。
  21. GC16456 M344 HDAC inhibitor
  22. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

  23. GC15114 LAQ824 (NVP-LAQ824,Dacinostat) A hydroxamate-based HDAC inhibitor
  24. GC13408 CI994 (Tacedinaline) An inhibitor of HDAC1, -2, and -3
  25. GC10839 Tubastatin A

    A potent HDAC6 inhibitor

  26. GC13706 Droxinostat An inhibitor of HDAC3, HDAC6, and HDAC8
  27. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
  28. GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor
  29. GC12115 CUDC-907 A dual inhibitor of HDACs and PI3Ks
  30. GC15962 Belinostat (PXD101)

    Belinostat 是一种有效的 HDAC 抑制剂, 在 HeLa 细胞提取物中的 IC50 为 27 nM。

  31. GC16734 Pracinostat (SB939)

    A pan-HDAC inhibitor

  32. GC15965 MC1568 A selective class IIa HDAC inhibitor
  33. GC15879 Resminostat (RAS2410) Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂,平均 IC50 值分别为 42.5、50.1、71.8 nM,对 HDAC8 的活性较低,IC50 为 877 nM .
  34. GC15002 Sodium Phenylbutyrate A chemical chaperone
  35. GC15315 Scriptaid HDAC inhibitor
  36. GC17836 ITF2357 (Givinostat)

    HDAC inhibitor with anti-inflammatory and antineoplastic activities

  37. GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2
  38. GC18008 PCI-34051 A potent, selective HDAC8 inhibitor
  39. GC15476 JNJ-26481585 A pan-HDAC inhibitor
  40. GC13055 Mocetinostat (MGCD0103, MG0103) An orally available HDAC inhibitor
  41. GC17390 Vorinostat (SAHA, MK0683)

    An HDAC inhibitor

  42. GC14998 Rocilinostat (ACY-1215) A selective inhibitor of HDAC6
  43. GN10357 Parthenolide A natural inhibitor of NOD2 and NF-κB signaling
  44. GC12961 Apicidin

    A cell-permeable HDAC inhibitor

  45. GC11334 Romidepsin (FK228, depsipeptide) A class I HDAC inhibitor
  46. GC15526 Trichostatin A (TSA) A potent, reversible inhibitor of histone deacetylases
  47. GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor
  48. GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor

Items 101 to 147 of 147 total

per page
  1. 1
  2. 2
  3. 3

Set Descending Direction