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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker(DNA烷化剂/交联剂)

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Products for  DNA Alkylator/Crosslinker

  1. Cat.No. 产品名称 Information
  2. GC69882 SG2057 SG2057 (DRG16) 是一种含有戊二氧基键的 PBD 二聚体，该键选择性地结合 DNA 小沟中的序列，形成 DNA 链间和链内交联加合物。SG2057 是一种高效抗肿瘤剂。
  3. GC68332 4-Hydroperoxy Cyclophosphamide-d4 4-Hydroperoxy Cyclophosphamide-d4 是 4-Hydroperoxy cyclophosphamide 的氘代物。4-Hydroperoxy cyclophosphamide 是前药 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于死亡受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。
  4. GC52129 3-Amino-5-hydroxybenzoic Acid A biosynthetic precursor to ansamycin antibiotics
  5. GC52076 Temozolomide Acid An active metabolite of temozolomide
  6. GC64354 Bendamustine Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.
  7. GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent
  8. GC63154 PR-104 PR-104 是一种选择性缺氧激活的 DNA 交联剂，可用于多种异种肿瘤模型的研究。PR-104 作为氮芥的前体药物，可有效地转化为亲脂性较强的二硝基苯甲酰胺芥菜醇 PR-104A。
  9. GC63050 Lurbinectedin D3 Lurbinectedin D3 是 Lurbinectedin 的氘代物。Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂，具有高效的抗肿瘤活性; 抑制 RMG1 和 RMG2 的 IC50 值分别为 1.25 和 1.16 nM。
  10. GC62691 SG3199 SG3199 是一种具有细胞毒性的 DNA 小沟链间交联 PDB 二聚体。SG3199 是 ADC 有效载荷 Tesirine (SG3249) 的组成成分。
  11. GC62501 OBI-3424 OBI-3424 (TH-3424) 是一种前药，可通过 AKR1C3 (醛基酮还原酶 1C3) 选择性地转化为有效的 DNA 烷基化剂。OBI-3424 可用于肝细胞癌，去势抵抗性前列腺癌和急性淋巴细胞白血病 (ALL) 的研究。
  12. GC62490 PR-104A PR-104A (SN 27858) 是磷酸盐前药 PR-104 的醇代谢物。PR-104A 是一种缺氧选择性的 DNA 交联剂/DNA 损伤剂，也是一种细胞毒素。具有抗肿瘤活性。PR-104A 在缺氧条件下通过 1-电子 NADPH:细胞色素 P450 氧化还原酶代谢。可用于复发/难治性 T 系急性淋巴细胞白血病 (T-ALL) 的研究。
  13. GC46962 Busulfan-d8 An internal standard for the quantification of busulfan
  14. GC61188 PIP-199

    PIP-199是一种RecQ介导的基因组不稳定蛋白RMI核心复合物/MM2相互作用(RMIcorecomplex/MM2interaction)的选择性抑制剂，其IC50值为36μM。MM2是FANCM上RMI复合物的结合位点。PIP-199可用于耐受肿瘤对DNA交联化疗药物的增敏研究。
  15. GC61182 Phosphoramide mustard (cyclohexanamine) An alkylating agent and active metabolite of cyclophosphamide
  16. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-DuocarmycinSA是一种DNA烷化剂(DNAalkylator)，可作为抗体药物偶联物的毒素部分(ADCcytotoxin)起作用。
  17. GC39498 N-Nitroso-N-methylurea N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.
  18. GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM 是 Duocarmycins 家族的一种 DNA 烷化剂，可抑制 DNA 合成。Seco-Duocarmycin TM 是一种细胞毒性剂，用作抗体-药物偶联物中的细胞毒性成分。
  19. GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体-药物偶联物 (ADC) 的毒素部分。
  20. GC38080 Duocarmycin Analog Duocarmycin Analog 是 Duocarmycin 的类似物，可用作 DNA 烷化剂 (DNA alkylator) 和 抗体-药物偶联物 (ADC cytotoxin) 的毒素部分。
  21. GC37860 Uramustine Uramustine 是一种可口服的烷化剂 (alkylator)，可用于治疗淋巴肉瘤、慢性淋巴性白血病和血小板增多症。
  22. GC37625 Semustine Semustine 是一种 DNA 烷化剂，与 DNA 结合，作为癌症化疗剂。
  23. GC37593 Satraplatin An orally available antineoplastic platinum(IV) complex
  24. GC36615 Miriplatin hydrate Miriplatin hydrate (SM-11355 hydrate) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。
  25. GC36598 Methylnitronitrosoguanidine(wetted with ca. 50% Water)

    Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent, shows toxic and mutagenic effects.
  26. GC35911 Duocarmycin MB Duocarmycin MB 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin MB 可用于抗多药耐药细胞系。
  27. GC35910 Duocarmycin MA Duocarmycin MA 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin MA 可用于抗多药耐药细胞系。
  28. GC35909 Duocarmycin GA Duocarmycin GA 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin GA 可用于抗多药耐药细胞系。
  29. GC35907 Duocarmycin Duocarmycin 是一种 DNA 小沟烷化剂，是一种抗体药物偶联物 (ADC) 毒素。 Duocarmycin 基于其特有的弯曲吲哚结构和螺环丙基环己二烯酮亲电体发挥抗癌活性。
  30. GC35310 Altretamine hydrochloride An antineoplastic agent and GPX4 inhibitor
  31. GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  32. GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI1 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  33. GC44251 MTIC A DNA alkylating agent
  34. GC44243 Monohydroxy Melphalan (hydrochloride) A DNA alkylating agent
  35. GC43209 CB-1954 An antitumor prodrug
  36. GC42401 4-hydroperoxy Cyclophosphamide

    An activated analog of cyclophosphamide
  37. GC41384 K-TMZ A DNA alkylating agent
  38. GC41340 Illudin M A DNA alkylating agent
  39. GC34305 Bendamustine D4 (SDX-105 D4) BendamustineD4是Bendamustine的氘代化合物标准品。Bendamustine是一种DNA交联剂(DNAcrosslinker)，能够导致DNA断裂，具有烷基化和抗代谢物的作用。
  40. GC34086 SJG-136 (NSC-694501) SJG-136 (NSC-694501) 是一种 DNA 交联剂，对于 pBR322 DNA 的 XL50 为 45 nM。 SJG-136 (NSC-694501) 具有有效的抗肿瘤活性。
  41. GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
  42. GC32918 Treosulfan (NSC 39069) Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
  43. GC32886 Miriplatin (SM-11355) Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
  44. GC32187 Duocarmycin TM DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。
  45. GC19086 Calicheamicin 加利车霉素是一种抗肿瘤抗生素，是一种导致双链 DNA 断裂的细胞毒剂。
  46. GC16158 Thio-TEPA An alkylating agent with anticancer activity
  47. GC12908 Chlorambucil A DNA alkylating agent
  48. GC15793 Carmustine A DNA alkylating agent
  49. GC11793 Procarbazine HCl A DNA methylating agent
  50. GC13667 Temozolomide

    Temozolomide is an oral activity alkylating agent that induces the formation of O6-methylguanine in DNA
  51. GC17865 Lomustine A DNA alkylating agent

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