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Glutathione Peroxidase(谷胱甘肽过氧化物酶)

Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Products for  Glutathione Peroxidase

  1. Cat.No. 产品名称 Information
  2. GC69468 Mitiperstat Mitiperstat (AZD4831) 是髓过氧化物酶 (MPO) 的有效抑制剂。Mitiperstat 在预防心血管疾病 (例如心力衰竭和冠状动脉疾病相关疾病) 的研究中特别有用 (信息提取自专利 US20160152623A1)。
  3. GC68468 MPO-IN-3 MPO-IN-3 是一种有效的 myeloperoxidase 抑制剂 (WO2013068875A1, example 191)。髓过氧化物酶 (MPO) 是一种含血红素的酶,属于过氧化物酶超家族。
  4. GC67918 MPO-IN-1 MPO-IN-1 是一种有效的, 具有口服活性的,不可逆的含有吲哚结构的髓过氧化物酶 (MPO) 抑制剂,对 MPO 和甲状腺过氧化物 (TPO) 的 IC50 值分别为 2.6 μM 和 5.3 μM。MPO-IN-1 在急性炎症小鼠模型中抑制 MPO 活性。
  5. GC63729 GPX4-IN-3 GPX4-IN-3 (26a) 是有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂,可选择性诱导铁死亡 (ferroptosis)。GPX4-IN-3 (26a) 在1 μM 的浓度可抑制GPX4 71.7% 活性。
  6. GC60263 N-Acetyl lysyltyrosylcysteine amide N-Acetyllysyltyrosylcysteineamide是一种有效的,可逆的,特异性且无毒的髓过氧化物酶(MPO)三肽抑制剂。N-Acetyllysyltyrosylcysteineamide在体内可有效抑制MPO产生有毒氧化剂。N-Acetyllysyltyrosylcysteineamide减轻中风后大脑的神经元损伤,并保留脑组织和神经功能。N-Acetyllysyltyrosylcysteineamide抑制MPO依赖性次氯酸(HOCl)的生成,蛋白质硝化和LDL氧化。
  7. GC36650 MPO-IN-28 MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.
  8. GC35139 4-Methylesculetin 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
  9. GC31882 Tinoridine hydrochloride (Y-3642 hydrochloride) Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.
  10. GC30783 AZD5904 A myeloperoxidase inhibitor
  11. GC30237 Verdiperstat (AZD3241) Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.
  12. GC19285 PF-06282999 A myeloperoxidase inhibitor
  13. GC18705 ML-210 A GPX4 inhibitor
  14. GC18256 PF-06281355 A myeloperoxidase inhibitor
  15. GC12431 RSL3

    谷胱甘肽过氧化物酶4抑制剂

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