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MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

  1. Cat.No. 产品名称 Information
  2. GC69554 NFF-3 TFA NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3 和 MMP-10 而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA,可在细胞实验中产生荧光,而检测细胞活性。
  3. GC69480 MMP-7-IN-1 MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM),而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
  4. GC69479 MMP2-IN-1 MMP2-IN-1 是一种中度有效的 MMP2 抑制剂,IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis),在某些癌细胞中表现出显著的抗增殖活性。
  5. GC68925 cyclo(RLsKDK) TFA cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂,IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
  6. GC68656 Andecaliximab Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。
  7. GP26168 MMP9 Mouse MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
  8. GP26167 MMP2 Mouse MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
  9. GC67947 Triolein 13C3 Triolein 13C3 是一种 13C 标记的 Triolein。Triolein 是一种对称三酰甘油,能够减少 MMP-1 的上调,具有很强的抗氧化、抗炎活性。
  10. GC65957 MMP13-IN-2 MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM),对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
  11. GC64992 YH-306 YH-306 是一种抗肿瘤剂。YH-306 通过 FAK 通路抑制结直肠肿瘤的生长和转移。 YH-306 显着抑制结直肠癌细胞的迁移和侵袭。YH-306 有效抑制不受抑制的增殖并诱导细胞凋亡 (apoptosis)。YH-306 抑制 FAK、c-Src、桩蛋白和 PI3K、Rac1 的激活以及 MMP2 和 MMP9 的表达。YH-306 还抑制肌动蛋白相关蛋白 (Arp2/3) 复合物介导的肌动蛋白聚合。
  12. GC64535 (S,S)-TAPI-1 A TACE inhibitor
  13. GC63661 Aderbasib Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性,可用于癌症研究,包括弥漫性大 B 细胞非霍奇金淋巴瘤,HER2+ 乳腺癌,胶质瘤等。
  14. GC63621 Doxycycline Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。
  15. GC63322 MMP13-IN-3 An inhibitor of MMP-13
  16. GC63132 Otaplimastat Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂,以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。
  17. GC62948 Edaravone D5 Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
  18. GC49142 Isorhoifolin A flavonoid glycoside with diverse biological activities
  19. GC62347 CMC2.24 CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂,通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂,IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。
  20. GC48421 GW 280264X An ADAM17/TACE and ADAM10 inhibitor
  21. GC48416 Chlorhexidine-d8 (hydrochloride) An internal standard for the quantification of chlorhexidine
  22. GC48093 Spiromesifen An insecticide and acaricide
  23. GC48060 Rosuvastatin-d6 (sodium salt) An internal standard for the quantification of rosuvastatin
  24. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide
  25. GC47847 Oxamyl A carbamate pesticide
  26. GC47712 Mycophenolate Mofetil-d4 An internal standard for the quantification of mycophenolate mofetil
  27. GC47660 Methyl Parathion An organophosphate insecticide
  28. GC47650 Methotrexate-d3 An internal standard for the quantification of methotrexate
  29. GC47648 Methomyl A carbamate insecticide
  30. GC47647 Methiocarb-d3 An internal standard for the quantification of methiocarb
  31. GC47646 Methiocarb A carbamate pesticide
  32. GC47366 Flurbiprofen-d3 An internal standard for the quantification of flurbiprofen
  33. GC47351 Fingolimod-d4 An internal standard for the quantification of fingolimod
  34. GC47339 Fenpropimorph A fungicide that inhibits the sterol pathway
  35. GC47326 Etoxazole An organofluorine acaricide
  36. GC47117 Colchicine-d6 An internal standard for the quantification of colchicine
  37. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib
  38. GC46890 Atorvastatin-d5 (calcium salt) An internal standard for the quantification of atorvastatin
  39. GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole
  40. GC46820 AHU377-d4 An internal standard for the quantification of AHU377
  41. GC46779 Acequinocyl A naphthoquinone acaricide
  42. GC46769 Abametapir A building block and an insecticide
  43. GC60860 FSL-1 TFA

    FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

  44. GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
  45. GC39640 GPLGIAGQ TFA

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽,在脂质体和胶束纳米载体中都被用作刺激敏感的连接物,用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。

  46. GC50353 T 26c disodium salt A selective inhibitor of MMP-13
  47. GC50189 TAPI 0 TAPI 0 是一种 TACE(TNF-α 转化酶;ADAM17)抑制剂,IC50 为 100 nM。
  48. GC46220 SD 2590 (hydrochloride) An MMP inhibitor
  49. GC39134 Isofraxidin Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
  50. GC39095 Isoliquiritin apioside Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
  51. GC38929 MMP-9-IN-1 MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.

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