MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
- Cat.No. 产品名称 Information
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GP26168
MMP9 Mouse
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
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GP26167
MMP2 Mouse
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
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GC67947
Triolein 13C3
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GC65957
MMP13-IN-2
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GC64992
YH-306
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GC64535
(S,S)-TAPI-1
A TACE inhibitor
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GC63661
Aderbasib
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GC63621
Doxycycline
Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
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GC63322
MMP13-IN-3
An inhibitor of MMP-13
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GC63132
Otaplimastat
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GC62948
Edaravone D5
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GC49142
Isorhoifolin
A flavonoid glycoside with diverse biological activities
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GC62347
CMC2.24
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GC48421
GW 280264X
An ADAM17/TACE and ADAM10 inhibitor
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GC48416
Chlorhexidine-d8 (hydrochloride)
An internal standard for the quantification of chlorhexidine
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GC48093
Spiromesifen
An insecticide and acaricide
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GC48060
Rosuvastatin-d6 (sodium salt)
An internal standard for the quantification of rosuvastatin
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GC47965
Pomalidomide-d5
An internal standard for the quantification of pomalidomide
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GC47847
Oxamyl
A carbamate pesticide
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GC47712
Mycophenolate Mofetil-d4
An internal standard for the quantification of mycophenolate mofetil
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GC47660
Methyl Parathion
An organophosphate insecticide
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GC47650
Methotrexate-d3
An internal standard for the quantification of methotrexate
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GC47648
Methomyl
A carbamate insecticide
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GC47647
Methiocarb-d3
An internal standard for the quantification of methiocarb
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GC47646
Methiocarb
A carbamate pesticide
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GC47366
Flurbiprofen-d3
An internal standard for the quantification of flurbiprofen
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GC47351
Fingolimod-d4
An internal standard for the quantification of fingolimod
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GC47339
Fenpropimorph
A fungicide that inhibits the sterol pathway
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GC47326
Etoxazole
An organofluorine acaricide
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GC47117
Colchicine-d6
An internal standard for the quantification of colchicine
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GC47042
Carfilzomib-d8
An internal standard for the quantification of carfilzomib
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GC47038
Carbofuran
A carbamate insecticide
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GC46890
Atorvastatin-d5 (calcium salt)
An internal standard for the quantification of atorvastatin
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GC46854
Anastrozole-d12
An internal standard for the quantification of anastrozole
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GC46820
AHU377-d4
An internal standard for the quantification of AHU377
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GC46779
Acequinocyl
A naphthoquinone acaricide
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GC46769
Abametapir
A building block and an insecticide
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GC60860
FSL-1 TFA
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
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GC60114
CTTHWGFTLC, CYCLIC TFA
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GC39640
GPLGIAGQ TFA
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GC50353
T 26c disodium salt
A selective inhibitor of MMP-13
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GC50189
TAPI 0
TAPI 0 是一种 TACE(TNF-α 转化酶;ADAM17)抑制剂,IC50 为 100 nM。
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GC46220
SD 2590 (hydrochloride)
An MMP inhibitor
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GC39134
Isofraxidin
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
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GC39095
Isoliquiritin apioside
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
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GC38929
MMP-9-IN-1
MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.
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GC46026
TMI 1
An ADAM and MMP inhibitor
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GC45978
1,10-Phenanthroline (hydrate)
A metal chelator and inhibitor of metalloproteases
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GC38871
XL-784 free base
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GC38837
Prinomastat hydrochloride
An inhibitor of MMP-2, -3, -9, -13, and -14