MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
- Cat.No. 产品名称 Information
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GC69554
NFF-3 TFA
NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3 和 MMP-10 而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA,可在细胞实验中产生荧光,而检测细胞活性。
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GC69480
MMP-7-IN-1
MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM),而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
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GC69479
MMP2-IN-1
MMP2-IN-1 是一种中度有效的 MMP2 抑制剂,IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis),在某些癌细胞中表现出显著的抗增殖活性。
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GC68925
cyclo(RLsKDK) TFA
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂,IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
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GC68656
Andecaliximab
Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。
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GP26168
MMP9 Mouse
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
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GP26167
MMP2 Mouse
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
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GC67947
Triolein 13C3
Triolein 13C3 是一种 13C 标记的 Triolein。Triolein 是一种对称三酰甘油,能够减少 MMP-1 的上调,具有很强的抗氧化、抗炎活性。
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GC65957
MMP13-IN-2
MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM),对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
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GC64992
YH-306
YH-306 是一种抗肿瘤剂。YH-306 通过 FAK 通路抑制结直肠肿瘤的生长和转移。 YH-306 显着抑制结直肠癌细胞的迁移和侵袭。YH-306 有效抑制不受抑制的增殖并诱导细胞凋亡 (apoptosis)。YH-306 抑制 FAK、c-Src、桩蛋白和 PI3K、Rac1 的激活以及 MMP2 和 MMP9 的表达。YH-306 还抑制肌动蛋白相关蛋白 (Arp2/3) 复合物介导的肌动蛋白聚合。
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GC64535
(S,S)-TAPI-1
A TACE inhibitor
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GC63661
Aderbasib
Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性,可用于癌症研究,包括弥漫性大 B 细胞非霍奇金淋巴瘤,HER2+ 乳腺癌,胶质瘤等。
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GC63621
Doxycycline
Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
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GC63322
MMP13-IN-3
An inhibitor of MMP-13
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GC63132
Otaplimastat
Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂,以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。
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GC62948
Edaravone D5
Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
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GC49142
Isorhoifolin
A flavonoid glycoside with diverse biological activities
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GC62347
CMC2.24
CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂,通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂,IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。
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GC48421
GW 280264X
An ADAM17/TACE and ADAM10 inhibitor
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GC48416
Chlorhexidine-d8 (hydrochloride)
An internal standard for the quantification of chlorhexidine
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GC48093
Spiromesifen
An insecticide and acaricide
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GC48060
Rosuvastatin-d6 (sodium salt)
An internal standard for the quantification of rosuvastatin
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GC47965
Pomalidomide-d5
An internal standard for the quantification of pomalidomide
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GC47847
Oxamyl
A carbamate pesticide
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GC47712
Mycophenolate Mofetil-d4
An internal standard for the quantification of mycophenolate mofetil
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GC47660
Methyl Parathion
An organophosphate insecticide
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GC47650
Methotrexate-d3
An internal standard for the quantification of methotrexate
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GC47648
Methomyl
A carbamate insecticide
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GC47647
Methiocarb-d3
An internal standard for the quantification of methiocarb
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GC47646
Methiocarb
A carbamate pesticide
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GC47366
Flurbiprofen-d3
An internal standard for the quantification of flurbiprofen
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GC47351
Fingolimod-d4
An internal standard for the quantification of fingolimod
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GC47339
Fenpropimorph
A fungicide that inhibits the sterol pathway
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GC47326
Etoxazole
An organofluorine acaricide
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GC47117
Colchicine-d6
An internal standard for the quantification of colchicine
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GC47042
Carfilzomib-d8
An internal standard for the quantification of carfilzomib
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GC47038
Carbofuran
A carbamate insecticide
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GC46890
Atorvastatin-d5 (calcium salt)
An internal standard for the quantification of atorvastatin
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GC46854
Anastrozole-d12
An internal standard for the quantification of anastrozole
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GC46820
AHU377-d4
An internal standard for the quantification of AHU377
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GC46779
Acequinocyl
A naphthoquinone acaricide
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GC46769
Abametapir
A building block and an insecticide
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GC60860
FSL-1 TFA
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
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GC60114
CTTHWGFTLC, CYCLIC TFA
CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
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GC39640
GPLGIAGQ TFA
GPLGIAGQ TFA 是一种 MMP2 可切割的多肽,在脂质体和胶束纳米载体中都被用作刺激敏感的连接物,用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
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GC50353
T 26c disodium salt
A selective inhibitor of MMP-13
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GC50189
TAPI 0
TAPI 0 是一种 TACE(TNF-α 转化酶;ADAM17)抑制剂,IC50 为 100 nM。
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GC46220
SD 2590 (hydrochloride)
An MMP inhibitor
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GC39134
Isofraxidin
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
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GC39095
Isoliquiritin apioside
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.