HSP(热休克蛋白)
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
- Cat.No. 产品名称 Information
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GC68450
Hsp90-IN-17 hydrochloride
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GC67916
Palmitic acid-d4
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GC66059
YZ129
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GC65318
BOLD-100
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GC65035
Apatorsen
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GC64988
Grp94 Inhibitor-1
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GC64795
Geldanamycin-FITC
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GC64714
NCT-58
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GC64685
SNX-0723
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GC64655
NXP800
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GC64370
Kongensin A
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GC63852
Palmitic acid-d3
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GC63796
116-9e
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GC63282
Icapamespib
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GC62388
YUM70
YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.
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GC62305
DDO-5936
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GC62120
DTHIB
DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.
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GC61784
HS-27
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GC61582
3-Phenyltoxoflavin
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GC61563
Aminohexylgeldanamycin
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GC48124
Tamoxifen-d5
An internal standard for the quantification of tamoxifen
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GC39477
AMP-PCP disodium
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GC50153
BIX
An inducer of GRP78
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GC45926
Nelfinavir-d3
An internal standard for the quantification of nelfinavir
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GC38503
HSP27 inhibitor J2
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GC38223
Dihydroberberine
Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
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GC37040
PU-H71 hydrochloride
PU-H71 hydrochloride 是一种有效的 Hsp90 抑制剂,在 MDA-MB-468 细胞中,对 Hsp90 的 IC50 值为 51 nM。
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GC36834
p5 Ligand for Dnak and DnaJ
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GC35757
Cucurbitacin D
A triterpenoid with diverse biological activities
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GC43649
Falcarinol
A plant defense polyacetylene
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GC41955
17-DMAG
Water-soluble inhibitor of Hsp90
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GC41532
Benzisoxazole Hsp90 Inhibitor
Hsp90 chaperone inhibitor
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GC40724
Heat Shock Protein Inhibitor II
Prevents the synthesis of inducible heat shock proteins
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GC34634
JG-98
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
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GC34539
Col003
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GC33663
Teprenone (Geranylgeranylacetone)
An inducer of Hsp expression
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GC33426
Rocaglamide (Rocaglamide A)
Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae).
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GC33286
TAS-116
An Hsp90 inhibitor
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GC33047
SNX-5422 Mesylate (PF-04929113 (Mesylate))
A prodrug for an Hsp90 inhibitor
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GC32965
Ethoxyquin
An antioxidant used in animal feed
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GC32869
HSP70-IN-1
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GC32620
Bimoclomol
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GC32437
HSF1A
HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.
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GC32008
Feretoside
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GC31118
KU-32
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GC31103
Arimoclomol maleate (BRX-220)
A co-inducer of heat shock proteins
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GC19215
KRIBB11
An Hsf1 inhibitor
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GC19188
HA15
An inhibitor of GRP78
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GC19121
Debio 0932
An Hsp90 inhibitor
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GC19094
CCT251236
An inhibitor of Hsf1-mediated transcription