HSP(热休克蛋白)
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
Products for HSP
- Cat.No. 产品名称 Information
- GC19215 KRIBB11 An Hsf1 inhibitor
- GC19188 HA15 An inhibitor of GRP78
- GC19121 Debio 0932 An Hsp90 inhibitor
- GC19094 CCT251236 An inhibitor of Hsf1-mediated transcription
- GC18832 Conglobatin An Hsp90 inhibitor
- GC18170 ML-346 An activator of the heat shock response
- GC11912 PF-04929113 (SNX-5422) A prodrug for an Hsp90 inhibitor
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GC13414
AT13387
A selective inhibitor of Hsp90
- GC14411 Apoptozole An inhibitor of Hsp70
- GC17901 Tamoxifen Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除[1-4]。
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GC13307
PU-WS13
Grp94 特异性 Hsp90 抑制剂
- GC11930 KNK437 Prevents the synthesis of inducible heat shock proteins
- GC14776 EC 144 EC 144 是一种有效的选择性热休克蛋白 90 (Hsp90) 抑制剂,IC50 为 1.1 nM。 EC 144 抑制肿瘤生长并导致部分肿瘤消退。 EC 144 具有研究癌症疾病的潜力。
- GC11973 HSP990 (NVP-HSP990) An Hsp90 inhibitor
- GC10881 Gedunin A natural inhibitor of p23 A natural inhibitor of p23
- GC17751 MKT 077 An Hsp70 inhibitor
- GC10481 TRC 051384 TRC 051384 是一种热休克蛋白 70 (HSP70) 诱导剂。
- GC15042 Macbecin I An Hsp90 inhibitor
- GC13556 VER-49009 An Hsp90 inhibitor
- GC10501 VER-50589 Inhibitor of Hsp90
- GC12301 Mizoribine An imidazole nucleoside with immunosuppressive properties
- GC11669 Tamoxifen Citrate A selective estrogen receptor modulator
- GC13044 17-DMAG (Alvespimycin) HCl Water-soluble inhibitor of Hsp90
- GC11065 Pifithrin-μ Inhibitor of p53-mediated apoptosis
- GC10327 Retaspimycin Retaspimycin 是一种有效的 Hsp90 抑制剂,对 Hsp90 和 Grp9 的 EC50 均为 119 nM。
- GC17210 17-AAG Hydrochloride Hsp90 inhibitor,geldanamycin analogue
- GC16892 XL-888 An orally bioavailable Hsp90 inhibitor
- GC16966 VER 155008 An Hsp70 inhibitor
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GC13885
Elesclomol (STA-4783)
An apoptosis inducer
- GC17655 Ganetespib (STA-9090) Ganetespib (STA-9090) (STA-9090) 是一种热休克蛋白 90 (HSP90) 抑制剂,在多种血液和实体肿瘤细胞系中表现出强效细胞毒性。 Ganetespib (STA-9090) 通过抑制 HIF-1α 在结直肠癌中具有抗血管生成作用;和 STAT3。
- GC13946 SNX-2112 A potent Hsp90 inhibitor
- GC11403 Radicicol An inhibitor of Hsp90
- GC11179 NVP-BEP800 An Hsp90 inhibitor
- GC14322 MPC-3100 An inhibitor of Hsp90
- GC14636 KW-2478 An Hsp90 inhibitor
- GC11391 IPI-504 (Retaspimycin hydrochloride) IPI-504 (Retaspimycin hydrochloride) 是一种有效的 Hsp90 抑制剂,对 Hsp90 和 Grp9 的 EC50 均为 119 nM。
- GC16361 Geldanamycin Binds Hsp90 and GRP94, inhibits growth of cancer cells
- GC12218 BIIB021 A potent, orally-available Hsp90 inhibitor
- GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor
- GC11720 17-AAG (KOS953) An inhibitor of Hsp90