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Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

Products for  DPP-4

  1. Cat.No. 产品名称 Information
  2. GC12235 Sitagliptin (phosphate) A DPP-4 inhibitor
  3. GC14786 P32/98 (hemifumarate) A DPP IV inhibitor
  4. GC17012 MK3102 MK3102 (Omarigliptin) is a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50: 2.
  5. GC10018 Talabostat mesylate

    塔拉司他Talabostat (PT100)是二肽基肽酶DPP的抑制剂,对DPP-IV、DPP8、DPP9、QPP、FAP和PEP的IC50值分别为<4 nM、4 nM、11 nM、310 nM、560 nM和390 nM。它具有抗肿瘤和刺激造血作用的活性。

  6. GC12895 Saxagliptin A potent DPP-4 inhibitor
  7. GC14126 NVP DPP 728 dihydrochloride NVP DPP 728 dihydrochloride 是一种有效的、可逆的和腈依赖性二肽基肽酶 IV (DPP-IV) 抑制剂。
  8. GC14201 PK 44 phosphate DPP-IV inhibitor
  9. GC10802 K 579 K 579 是一种有效且具有口服活性的二肽基肽酶 IV 抑制剂。
  10. GC12603 DPPI 1c hydrochloride A DPP-4 inhibitor
  11. GC17479 Trelagliptin succinate A DDP-4 inhibitor
  12. GC16613 Trelagliptin A DDP-4 inhibitor
  13. GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor
  14. GC13949 Alogliptin Benzoate A DPP-4 inhibitor
  15. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂,IC50 <10 nM,选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
  16. GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor
  17. GC10298 Sitagliptin phosphate monohydrate Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞提取物中的 IC50 为 19 nM。
  18. GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
  19. GC10104 Glimepiride An antidiabetic sulfonylurea

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