DPP-4(二肽基肽酶4)
Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.
- Cat.No. 产品名称 Information
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GC12235
Sitagliptin (phosphate)
A DPP-4 inhibitor
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GC14786
P32/98 (hemifumarate)
A DPP IV inhibitor
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GC17012
MK3102
MK3102 (Omarigliptin) is a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50: 2.
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GC10018
Talabostat mesylate
A non-selective inhibitor of dipeptidyl peptidases
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GC12895
Saxagliptin
A potent DPP-4 inhibitor
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GC14126
NVP DPP 728 dihydrochloride
NVP DPP 728 dihydrochloride 是一种有效的、可逆的和腈依赖性二肽基肽酶 IV (DPP-IV) 抑制剂。
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GC14201
PK 44 phosphate
DPP-IV inhibitor
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GC10802
K 579
K 579 是一种有效且具有口服活性的二肽基肽酶 IV 抑制剂。
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GC12603
DPPI 1c hydrochloride
A DPP-4 inhibitor
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GC17479
Trelagliptin succinate
A DDP-4 inhibitor
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GC16613
Trelagliptin
A DDP-4 inhibitor
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GC15576
Teneligliptin hydrobromide
A DPP-4 inhibitor
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GC13949
Alogliptin Benzoate
A DPP-4 inhibitor
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GC15130
Alogliptin (SYR-322)
Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂,IC50 <10 nM,选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
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GC16733
Vildagliptin (LAF-237)
A DPP-4 inhibitor
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GC10298
Sitagliptin phosphate monohydrate
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞提取物中的 IC50 为 19 nM。
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GC14827
Linagliptin (BI-1356)
A potent DPP-4 inhibitor
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GC10104
Glimepiride
An antidiabetic sulfonylurea