Home >> Signaling Pathways >> Proteases >> Caspase


Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

  1. Cat.No. 产品名称 Information
  2. GC26092 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
  3. GC66403 Z-DEVD-AMC
  4. GC66048 δ-Secretase inhibitor 11 Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM.
  5. GC65474 QM31
  6. GC63914 Raptinal
  7. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11
  8. GC63256 VRT-043198
  9. GC63031 KEA1-97
  10. GC62567 Pralnacasan
  11. GC62444 SDZ 224-015
  12. GC60603 Asperosaponin VI A triterpenoid saponin with diverse biological activities
  13. GC60558 Ac-FLTD-CMK An inhibitor of caspase-1, -4, -5, and -11
  14. GC50368 INF 4E INF 4E 是一种有效的 NLRP3 炎性体抑制剂。
  15. GC38452 Dehydrotrametenolic acid
  16. GC45515 MX1013 A dipeptide pan-caspase inhibitor
  17. GC37974 ZYZ-488
  18. GC37780 Thevetiaflavone
  19. GC37745 Taurodeoxychloic Acid sodium hydrate Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
  20. GC36895 Phenoxodiol A phenol with anticancer activity
  21. GC36855 Paris saponin VII Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  22. GC36652 MPT0B392
  23. GC36516 Lycopodine
  24. GC35980 Emricasan A pan-caspase inhibitor
  25. GC35908 Duocarmycin A
  26. GC35395 Arnicolide D A sesquiterpene lactone with anticancer activity
  27. GC35388 Aristolactam I
  28. GC35150 5,7,4'-Trimethoxyflavone 4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
  29. GC45189 Z-VAD(OH)-FMK An irreversible pan-caspase inhibitor
  30. GC44409 Nivalenol A trichothecene mycotoxin
  31. GC43154 CAY10443 A cytochrome c-dependent inducer of apoptosis
  32. GC34831 Tauroursodeoxycholate dihydrate
  33. GC34181 Tauroursodeoxycholate (TUDCA) A taurine-conjugated form of ursodeoxycholic acid
  34. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) A quantitative analytical standard guaranteed to meet MaxSpec? identity, purity, stability, and concentration specifications
  35. GC33309 ML132 (NCGC 00185682)
  36. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
  37. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
  38. GC31886 Chelidonic acid A pyran with diverse biological activities
  39. GC31390 EP1013 (F1013)
  40. GC18476 Biotin-VAD-FMK A biotin-conjugated pan-caspase inhibitor
  41. GC12861 Z-VAD-FMK

    A cell-permeable caspase inhibitor

  42. GC12223 Z-Asp-CH2-DCB A pan-caspase inhibitor
  43. GC11988 15-acetoxy Scirpenol A trichothecene mycotoxin
  44. GC10661 Destruxin B An insecticidal mycotoxin
  45. GC15880 Penicillic Acid A mycotoxin that inhibits quorum sensing
  46. GC12545 2-HBA An indirect inhibitor of Keap1-Nrf2 interactions
  47. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达,例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。
  48. GC14188 Z-YVAD-FMK Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性 caspase-1 和 -4 抑制剂。
  49. GC17658 Guggulsterone Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
  50. GC16990 Z-LEHD-FMK Z-LEHD-FMK 是一种选择性且不可逆的 caspase-9 抑制剂,可防止致命的再灌注损伤并减轻细胞凋亡。
  51. GC12407 Z-IETD-FMK Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性和细胞可渗透的 caspase-8 抑制剂。 Z-IETD-FMK 也是一种颗粒酶 B 抑制剂。

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