Caspase(半胱天冬酶蛋白)
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- Cat.No. 产品名称 Information
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GC26092
Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
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GC66403
Z-DEVD-AMC
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GC66048
δ-Secretase inhibitor 11
Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM.
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GC65474
QM31
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GC63914
Raptinal
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GC49704
Ac-FLTD-CMK (trifluoroacetate salt)
An inhibitor of caspase-1, -4, -5, and -11
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GC63256
VRT-043198
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GC63031
KEA1-97
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GC62567
Pralnacasan
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GC62444
SDZ 224-015
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GC60603
Asperosaponin VI
A triterpenoid saponin with diverse biological activities
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GC60558
Ac-FLTD-CMK
An inhibitor of caspase-1, -4, -5, and -11
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GC50368
INF 4E
INF 4E 是一种有效的 NLRP3 炎性体抑制剂。
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GC38452
Dehydrotrametenolic acid
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GC45515
MX1013
A dipeptide pan-caspase inhibitor
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GC37974
ZYZ-488
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GC37780
Thevetiaflavone
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GC37745
Taurodeoxychloic Acid sodium hydrate
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
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GC36895
Phenoxodiol
A phenol with anticancer activity
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GC36855
Paris saponin VII
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
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GC36652
MPT0B392
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GC36516
Lycopodine
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GC35980
Emricasan
A pan-caspase inhibitor
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GC35908
Duocarmycin A
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GC35395
Arnicolide D
A sesquiterpene lactone with anticancer activity
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GC35388
Aristolactam I
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GC35150
5,7,4'-Trimethoxyflavone
4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
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GC45189
Z-VAD(OH)-FMK
An irreversible pan-caspase inhibitor
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GC44409
Nivalenol
A trichothecene mycotoxin
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GC43154
CAY10443
A cytochrome c-dependent inducer of apoptosis
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GC34831
Tauroursodeoxycholate dihydrate
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GC34181
Tauroursodeoxycholate (TUDCA)
A taurine-conjugated form of ursodeoxycholic acid
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GC33825
Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
A quantitative analytical standard guaranteed to meet MaxSpec? identity, purity, stability, and concentration specifications
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GC33309
ML132 (NCGC 00185682)
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GC32998
Ginsenoside Rh4
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
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GC32695
Ac-DEVD-CHO
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
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GC31886
Chelidonic acid
A pyran with diverse biological activities
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GC31390
EP1013 (F1013)
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GC18476
Biotin-VAD-FMK
A biotin-conjugated pan-caspase inhibitor
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GC12861
Z-VAD-FMK
A cell-permeable caspase inhibitor
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GC12223
Z-Asp-CH2-DCB
A pan-caspase inhibitor
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GC11988
15-acetoxy Scirpenol
A trichothecene mycotoxin
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GC10661
Destruxin B
An insecticidal mycotoxin
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GC15880
Penicillic Acid
A mycotoxin that inhibits quorum sensing
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GC12545
2-HBA
An indirect inhibitor of Keap1-Nrf2 interactions
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GC17425
Sodium Tauroursodeoxycholate (TUDC)
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达,例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。
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GC14188
Z-YVAD-FMK
Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性 caspase-1 和 -4 抑制剂。
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GC17658
Guggulsterone
Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
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GC16990
Z-LEHD-FMK
Z-LEHD-FMK 是一种选择性且不可逆的 caspase-9 抑制剂,可防止致命的再灌注损伤并减轻细胞凋亡。
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GC12407
Z-IETD-FMK
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性和细胞可渗透的 caspase-8 抑制剂。 Z-IETD-FMK 也是一种颗粒酶 B 抑制剂。